Chen Cao

Chao Chai, Pengchong Qiao, Bin Zhao et al.

Abnormal iron accumulation in the brain subcortical nuclei has been reported to be correlated to various neurodegenerative diseases, which can be measured through the magnetic susceptibility from the quantitative susceptibility mapping (QSM). To quantitively measure the magnetic susceptibility, the nuclei should be accurately segmented, which is a tedious task for clinicians. In this paper, we proposed a double-branch residual-structured U-Net (DB-ResUNet) based on 3D convolutional neural network (CNN) to automatically segment such brain gray matter nuclei. To better tradeoff between segmentation accuracy and the memory efficiency, the proposed DB-ResUNet fed image patches with high resolution and the patches with low resolution but larger field of view into the local and global branches, respectively. Experimental results revealed that by jointly using QSM and T$_\text{1}$ weighted imaging (T$_\text{1}$WI) as inputs, the proposed method was able to achieve better segmentation accuracy over its single-branch counterpart, as well as the conventional atlas-based method and the classical 3D-UNet structure. The susceptibility values and the volumes were also measured, which indicated that the measurements from the proposed DB-ResUNet are able to present high correlation with values from the manually annotated regions of interest.

Bin Zhao, Shuxue Ding, Hong Wu et al.

Ischemic stroke is a common disease in the elderly population, which can cause long-term disability and even death. However, the time window for treatment of ischemic stroke in its acute stage is very short. To fast localize and quantitively evaluate the acute ischemic stroke (AIS) lesions, many deep-learning-based lesion segmentation methods have been proposed in the literature, where a deep convolutional neural network (CNN) was trained on hundreds of fully labeled subjects with accurate annotations of AIS lesions. Despite that high segmentation accuracy can be achieved, the accurate labels should be annotated by experienced clinicians, and it is therefore very time-consuming to obtain a large number of fully labeled subjects. In this paper, we propose a semi-supervised method to automatically segment AIS lesions in diffusion weighted images and apparent diffusion coefficient maps. By using a large number of weakly labeled subjects and a small number of fully labeled subjects, our proposed method is able to accurately detect and segment the AIS lesions. In particular, our proposed method consists of three parts: 1) a double-path classification net (DPC-Net) trained in a weakly-supervised way is used to detect the suspicious regions of AIS lesions; 2) a pixel-level K-Means clustering algorithm is used to identify the hyperintensive regions on the DWIs; and 3) a region-growing algorithm combines the outputs of the DPC-Net and the K-Means to obtain the final precise lesion segmentation. In our experiment, we use 460 weakly labeled subjects and 15 fully labeled subjects to train and fine-tune the proposed method. By evaluating on a clinical dataset with 150 fully labeled subjects, our proposed method achieves a mean dice coefficient of 0.642, and a lesion-wise F1 score of 0.822.

Zhiyang Liu, Chen Cao, Shuxue Ding et al.

The patient with ischemic stroke can benefit most from the earliest possible definitive diagnosis. While the high quality medical resources are quite scarce across the globe, an automated diagnostic tool is expected in analyzing the magnetic resonance (MR) images to provide reference in clinical diagnosis. In this paper, we propose a deep learning method to automatically segment ischemic stroke lesions from multi-modal MR images. By using atrous convolution and global convolution network, our proposed residual-structured fully convolutional network (Res-FCN) is able to capture features from large receptive fields. The network architecture is validated on a large dataset of 212 clinically acquired multi-modal MR images, which is shown to achieve a mean dice coefficient of 0.645 with a mean number of false negative lesions of 1.515. The false negatives can reach a value that close to a common medical image doctor, making it exceptive for a real clinical application.