Zhenxi Song

Xiongri Shen, Zhenxi Song, Zhiguo Zhang

Diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) from fMRI functional connectivity (FC) has gained popularity, but most FC-based diagnostic models are black boxes lacking casual reasoning so they contribute little to the knowledge about FC-based neural biomarkers of cognitive decline.To enhance the explainability of diagnostic models, we propose a generative counterfactual attention-guided network (GCAN), which introduces counterfactual reasoning to recognize cognitive decline-related brain regions and then uses these regions as attention maps to boost the prediction performance of diagnostic models. Furthermore, to tackle the difficulty in the generation of highly-structured and brain-atlas-constrained FC, which is essential in counterfactual reasoning, an Atlas-Aware Bidirectional Transformer (AABT) method is developed. AABT employs a bidirectional strategy to encode and decode the tokens from each network of brain atlas, thereby enhancing the generation of high-quality target label FC. In the experiments of hospital-collected and ADNI datasets, the generated attention maps closely resemble FC abnormalities in the literature on SCD and MCI. The diagnostic performance is also superior to baseline models. The code is available at https://github.com/SXR3015/GCAN

Xiongri Shen, Zhenxi Song, Linling Li et al.

Early diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) utilizing multi-modal magnetic resonance imaging (MRI) is a pivotal area of research. While various regional and connectivity features from functional MRI (fMRI) and diffusion tensor imaging (DTI) have been employed to develop diagnosis models, most studies integrate these features without adequately addressing their alignment and interactions. This limits the potential to fully exploit the synergistic contributions of combined features and modalities. To solve this gap, our study introduces a novel Hierarchical Alignments and Hierarchical Interactions (HA-HI) method for MCI and SCD classification, leveraging the combined strengths of fMRI and DTI. HA-HI efficiently learns significant MCI- or SCD- related regional and connectivity features by aligning various feature types and hierarchically maximizing their interactions. Furthermore, to enhance the interpretability of our approach, we have developed the Synergistic Activation Map (SAM) technique, revealing the critical brain regions and connections that are indicative of MCI/SCD. Comprehensive evaluations on the ADNI dataset and our self-collected data demonstrate that HA-HI outperforms other existing methods in diagnosing MCI and SCD, making it a potentially vital and interpretable tool for early detection. The implementation of this method is publicly accessible at https://github.com/ICI-BCI/Dual-MRI-HA-HI.git.

Xiaopeng Ke, Hexuan Deng, Xuebo Liu et al.

Despite the impressive performance of large language models (LLMs) in general domains, they often underperform in specialized domains. Existing approaches typically rely on data synthesis methods and yield promising results by using unlabeled data to capture domain-specific features. However, these methods either incur high computational costs or suffer from performance limitations, while also demonstrating insufficient generalization across different tasks. To address these challenges, we propose AQuilt, a framework for constructing instruction-tuning data for any specialized domains from corresponding unlabeled data, including Answer, Question, Unlabeled data, Inspection, Logic, and Task type. By incorporating logic and inspection, we encourage reasoning processes and self-inspection to enhance model performance. Moreover, customizable task instructions enable high-quality data generation for any task. As a result, we construct a dataset of 703k examples to train a powerful data synthesis model. Experiments show that AQuilt is comparable to DeepSeek-V3 while utilizing just 17% of the production cost. Further analysis demonstrates that our generated data exhibits higher relevance to downstream tasks. Source code, models, and scripts are available at https://github.com/Krueske/AQuilt.

Guoyang Xu, Zhenxi Song, Junqi Xue et al.

Achieving consistent sentiment representation across diverse modalities remains a key challenge in multimodal sentiment analysis. However, rapid emotional fluctuations over time often introduce instability, leading to compromised prediction performance. To address this challenge, we propose a robust sentiment representation dual enhancement strategy that simultaneously enhances the temporal and modality dimensions, guided by targeted mechanisms in both forward and backward propagation. Specifically, in the modality dimension, we introduce a modality invariant fusion mechanism that fosters stable cross-modal representations, which aim to capture the common and stable representations shared across different modalities. In the temporal dimension, we impose a specialized sequential variation regularization term that regulates the model's learning trajectory during backward propagation, which is essentially total variation regularization degenerated into one-dimensional linear differences. Extensive experiments on three standard public datasets validate the effectiveness of our proposed approach.

Jiaqi Wang, Zhenxi Song, Zhengyu Ma et al.

Reconstructing natural language from non-invasive electroencephalography (EEG) holds great promise as a language decoding technology for brain-computer interfaces (BCIs). However, EEG-based language decoding is still in its nascent stages, facing several technical issues such as: 1) Absence of a hybrid strategy that can effectively integrate cross-modality (between EEG and text) self-learning with intra-modality self-reconstruction of EEG features or textual sequences; 2) Under-utilization of large language models (LLMs) to enhance EEG-based language decoding. To address above issues, we propose the Contrastive EEG-Text Masked Autoencoder (CET-MAE), a novel model that orchestrates compound self-supervised learning across and within EEG and text through a dedicated multi-stream encoder. Furthermore, we develop a framework called E2T-PTR (EEG-to-Text decoding using Pretrained Transferable Representations), which leverages pre-trained modules alongside the EEG stream from CET-MAE and further enables an LLM (specifically BART) to decode text from EEG sequences. Comprehensive experiments conducted on the popular text-evoked EEG database, ZuCo, demonstrate the superiority of E2T-PTR, which outperforms the state-of-the-art in ROUGE-1 F1 and BLEU-4 scores by 8.34% and 32.21%, respectively. These results indicate significant advancements in the field and underscores the proposed framework's potential to enable more powerful and widespread BCI applications.

Jilong Li, Zhenxi Song, Jiaqi Wang et al.

Current EEG/MEG-to-text decoding systems suffer from three key limitations: (1) reliance on teacher-forcing methods, which compromises robustness during inference, (2) sensitivity to session-specific noise, hindering generalization across subjects, and (3) misalignment between brain signals and linguistic representations due to pre-trained language model over-dominance. To overcome these challenges, we propose BrainECHO (Brain signal decoding via vEctor-quantized speCtrogram reconstruction for WHisper-enhanced text generatiOn), a multi-stage framework that employs decoupled representation learning to achieve state-of-the-art performance on both EEG and MEG datasets. Specifically, BrainECHO consists of three stages: (1) Discrete autoencoding, which transforms continuous Mel spectrograms into a finite set of high-quality discrete representations for subsequent stages. (2) Frozen alignment, where brain signal embeddings are mapped to corresponding Mel spectrogram embeddings in a frozen latent space, effectively filtering session-specific noise through vector-quantized reconstruction, yielding a 3.65% improvement in BLEU-4 score. (3) Constrained decoding fine-tuning, which leverages the pre-trained Whisper model for audio-to-text translation, balancing signal adaptation with knowledge preservation, and achieving 74%-89% decoding BLEU scores without excessive reliance on teacher forcing. BrainECHO demonstrates robustness across sentence, session, and subject-independent conditions, passing Gaussian noise tests and showcasing its potential for enhancing language-based brain-computer interfaces.

Zhenxi Song, Ruihan Qin, Huixia Ren et al.

Cross-center data heterogeneity and annotation unreliability significantly challenge the intelligent diagnosis of diseases using brain signals. A notable example is the EEG-based diagnosis of neurodegenerative diseases, which features subtler abnormal neural dynamics typically observed in small-group settings. To advance this area, in this work, we introduce a transferable framework employing Manifold Attention and Confidence Stratification (MACS) to diagnose neurodegenerative disorders based on EEG signals sourced from four centers with unreliable annotations. The MACS framework's effectiveness stems from these features: 1) The Augmentor generates various EEG-represented brain variants to enrich the data space; 2) The Switcher enhances the feature space for trusted samples and reduces overfitting on incorrectly labeled samples; 3) The Encoder uses the Riemannian manifold and Euclidean metrics to capture spatiotemporal variations and dynamic synchronization in EEG; 4) The Projector, equipped with dual heads, monitors consistency across multiple brain variants and ensures diagnostic accuracy; 5) The Stratifier adaptively stratifies learned samples by confidence levels throughout the training process; 6) Forward and backpropagation in MACS are constrained by confidence stratification to stabilize the learning system amid unreliable annotations. Our subject-independent experiments, conducted on both neurocognitive and movement disorders using cross-center corpora, have demonstrated superior performance compared to existing related algorithms. This work not only improves EEG-based diagnostics for cross-center and small-setting brain diseases but also offers insights into extending MACS techniques to other data analyses, tackling data heterogeneity and annotation unreliability in multimedia and multimodal content understanding.

Jiaqi Wang, Liutao Yu, Liwei Huang et al.

The intrinsic dynamics and event-driven nature of spiking neural networks (SNNs) make them excel in processing temporal information by naturally utilizing embedded time sequences as time steps. Recent studies adopting this approach have demonstrated SNNs' effectiveness in speech command recognition, achieving high performance by employing large time steps for long time sequences. However, the large time steps lead to increased deployment burdens for edge computing applications. Thus, it is important to balance high performance and low energy consumption when detecting temporal patterns in edge devices. Our solution comprises two key components. 1). We propose a high-performance fully spike-driven framework termed SpikeSCR, characterized by a global-local hybrid structure for efficient representation learning, which exhibits long-term learning capabilities with extended time steps. 2). To further fully embrace low energy consumption, we propose an effective knowledge distillation method based on curriculum learning (KDCL), where valuable representations learned from the easy curriculum are progressively transferred to the hard curriculum with minor loss, striking a trade-off between power efficiency and high performance. We evaluate our method on three benchmark datasets: the Spiking Heidelberg Dataset (SHD), the Spiking Speech Commands (SSC), and the Google Speech Commands (GSC) V2. Our experimental results demonstrate that SpikeSCR outperforms current state-of-the-art (SOTA) methods across these three datasets with the same time steps. Furthermore, by executing KDCL, we reduce the number of time steps by 60% and decrease energy consumption by 54.8% while maintaining comparable performance to recent SOTA results. Therefore, this work offers valuable insights for tackling temporal processing challenges with long time sequences in edge neuromorphic computing systems.

Yuxin Liu, Zhenxi Song, Guoyang Xu et al.

Brain-computer interface (BCI) based on steady-state visual evoked potentials (SSVEP) is a popular paradigm for its simplicity and high information transfer rate (ITR). Accurate and fast SSVEP decoding is crucial for reliable BCI performance. However, conventional decoding methods demand longer time windows, and deep learning models typically require subject-specific fine-tuning, leaving challenges in achieving optimal performance in cross-subject settings. This paper proposed a biofocal masking attention-based method (SSVEP-BiMA) that synergistically leverages the native and symmetric-antisymmetric components for decoding SSVEP. By utilizing multiple signal representations, the network is able to integrate features from a wider range of sample perspectives, leading to more generalized and comprehensive feature learning, which enhances both prediction accuracy and robustness. We performed experiments on two public datasets, and the results demonstrate that our proposed method surpasses baseline approaches in both accuracy and ITR. We believe that this work will contribute to the development of more efficient SSVEP-based BCI systems.