Hideaki Hayashi

Takeaki Kadota, Hideaki Hayashi, Ryoma Bise et al.

Automatic image-based disease severity estimation generally uses discrete (i.e., quantized) severity labels. Annotating discrete labels is often difficult due to the images with ambiguous severity. An easier alternative is to use relative annotation, which compares the severity level between image pairs. By using a learning-to-rank framework with relative annotation, we can train a neural network that estimates rank scores that are relative to severity levels. However, the relative annotation for all possible pairs is prohibitive, and therefore, appropriate sample pair selection is mandatory. This paper proposes a deep Bayesian active-learning-to-rank, which trains a Bayesian convolutional neural network while automatically selecting appropriate pairs for relative annotation. We confirmed the efficiency of the proposed method through experiments on endoscopic images of ulcerative colitis. In addition, we confirmed that our method is useful even with the severe class imbalance because of its ability to select samples from minor classes automatically.

Takeaki Kadota, Hideaki Hayashi, Ryoma Bise et al.

Automatic image-based severity estimation is an important task in computer-aided diagnosis. Severity estimation by deep learning requires a large amount of training data to achieve a high performance. In general, severity estimation uses training data annotated with discrete (i.e., quantized) severity labels. Annotating discrete labels is often difficult in images with ambiguous severity, and the annotation cost is high. In contrast, relative annotation, in which the severity between a pair of images is compared, can avoid quantizing severity and thus makes it easier. We can estimate relative disease severity using a learning-to-rank framework with relative annotations, but relative annotation has the problem of the enormous number of pairs that can be annotated. Therefore, the selection of appropriate pairs is essential for relative annotation. In this paper, we propose a deep Bayesian active learning-to-rank that automatically selects appropriate pairs for relative annotation. Our method preferentially annotates unlabeled pairs with high learning efficiency from the model uncertainty of the samples. We prove the theoretical basis for adapting Bayesian neural networks to pairwise learning-to-rank and demonstrate the efficiency of our method through experiments on endoscopic images of ulcerative colitis on both private and public datasets. We also show that our method achieves a high performance under conditions of significant class imbalance because it automatically selects samples from the minority classes.

Naoya Yasukochi, Hideaki Hayashi, Daichi Haraguchi et al.

There are various font styles in the world. Different styles give different impressions and readability. This paper analyzes the relationship between font styles and contextual factors that might affect font style selection with large-scale datasets. For example, we will analyze the relationship between font style and its surrounding object (such as ``bus'') by using about 800,000 words in the Open Images dataset. We also use a book cover dataset to analyze the relationship between font styles with book genres. Moreover, the meaning of the word is assumed as another contextual factor. For these numeric analyses, we utilize our own font-style feature extraction model and word2vec. As a result of co-occurrence-based relationship analysis, we found several instances of specific font styles being used for specific contextual factors.

Yicheng Deng, Hideaki Hayashi, Hajime Nagahara

Facial expression spotting, identifying periods where facial expressions occur in a video, is a significant yet challenging task in facial expression analysis. The issues of irrelevant facial movements and the challenge of detecting subtle motions in micro-expressions remain unresolved, hindering accurate expression spotting. In this paper, we propose an efficient framework for facial expression spotting. First, we propose a Sliding Window-based multi-temporal-resolution Optical flow (SW-MRO) feature, which calculates multi-temporal-resolution optical flow of the input image sequence within compact sliding windows. The window length is tailored to perceive complete micro-expressions and distinguish between general macro- and micro-expressions. SW-MRO can effectively reveal subtle motions while avoiding the optical flow being dominated by head movements. Second, we propose SpotFormer, a multi-scale spatio-temporal Transformer that simultaneously encodes spatio-temporal relationships of the SW-MRO features for accurate frame-level probability estimation. In SpotFormer, we use the proposed Facial Local Graph Pooling (FLGP) operation and convolutional layers to extract multi-scale spatio-temporal features. We show the validity of the architecture of SpotFormer by comparing it with several model variants. Third, we introduce supervised contrastive learning into SpotFormer to enhance the discriminability between different types of expressions. Extensive experiments on SAMM-LV, CAS(ME)^2, and CAS(ME)^3 show that our method outperforms state-of-the-art models, particularly in micro-expression spotting.

Lorenzo S. Querol, Hajime Nagahara, Hideaki Hayashi

The growing use of deep learning in safety-critical applications, such as medical imaging, has raised concerns about limited labeled data, where this demand is amplified as model complexity increases, posing hurdles for domain experts to annotate data. In response to this, active learning (AL) is used to efficiently train models with limited annotation costs. In the context of deep neural networks (DNNs), AL often uses confidence or probability outputs as a score for selecting the most informative samples. However, modern DNNs exhibit unreliable confidence outputs, making calibration essential. We propose an AL framework that self-calibrates the confidence used for sample selection during the training process, referred to as Confident Active Learning with Integrated CalibratiOn (CALICO). CALICO incorporates the joint training of a classifier and an energy-based model, instead of the standard softmax-based classifier. This approach allows for simultaneous estimation of the input data distribution and the class probabilities during training, improving calibration without needing an additional labeled dataset. Experimental results showcase improved classification performance compared to a softmax-based classifier with fewer labeled samples. Furthermore, the calibration stability of the model is observed to depend on the prior class distribution of the data.

Ryosuke Kawamura, Hideaki Hayashi, Noriko Takemura et al.

Dynamic facial expression recognition (DFER) is an important task in the field of computer vision. To apply automatic DFER in practice, it is necessary to accurately recognize ambiguous facial expressions, which often appear in data in the wild. In this paper, we propose MIDAS, a data augmentation method for DFER, which augments ambiguous facial expression data with soft labels consisting of probabilities for multiple emotion classes. In MIDAS, the training data are augmented by convexly combining pairs of video frames and their corresponding emotion class labels, which can also be regarded as an extension of mixup to soft-labeled video data. This simple extension is remarkably effective in DFER with ambiguous facial expression data. To evaluate MIDAS, we conducted experiments on the DFEW dataset. The results demonstrate that the model trained on the data augmented by MIDAS outperforms the existing state-of-the-art method trained on the original dataset.

Yicheng Deng, Hideaki Hayashi, Hajime Nagahara

Facial expression spotting is a significant but challenging task in facial expression analysis. The accuracy of expression spotting is affected not only by irrelevant facial movements but also by the difficulty of perceiving subtle motions in micro-expressions. In this paper, we propose a Multi-Scale Spatio-Temporal Graph Convolutional Network (SpoT-GCN) for facial expression spotting. To extract more robust motion features, we track both short- and long-term motion of facial muscles in compact sliding windows whose window length adapts to the temporal receptive field of the network. This strategy, termed the receptive field adaptive sliding window strategy, effectively magnifies the motion features while alleviating the problem of severe head movement. The subtle motion features are then converted to a facial graph representation, whose spatio-temporal graph patterns are learned by a graph convolutional network. This network learns both local and global features from multiple scales of facial graph structures using our proposed facial local graph pooling (FLGP). Furthermore, we introduce supervised contrastive learning to enhance the discriminative capability of our model for difficult-to-classify frames. The experimental results on the SAMM-LV and CAS(ME)^2 datasets demonstrate that our method achieves state-of-the-art performance, particularly in micro-expression spotting. Ablation studies further verify the effectiveness of our proposed modules.

Ryosuke Kawamura, Hideaki Hayashi, Shunsuke Otake et al.

Dynamic facial expression recognition (DFER) is a task that estimates emotions from facial expression video sequences. For practical applications, accurately recognizing ambiguous facial expressions -- frequently encountered in in-the-wild data -- is essential. In this study, we propose MIDAS, a data augmentation method designed to enhance DFER performance for ambiguous facial expression data using soft labels representing probabilities of multiple emotion classes. MIDAS augments training data by convexly combining pairs of video frames and their corresponding emotion class labels. This approach extends mixup to soft-labeled video data, offering a simple yet highly effective method for handling ambiguity in DFER. To evaluate MIDAS, we conducted experiments on both the DFEW dataset and FERV39k-Plus, a newly constructed dataset that assigns soft labels to an existing DFER dataset. The results demonstrate that models trained with MIDAS-augmented data achieve superior performance compared to the state-of-the-art method trained on the original dataset.

Yicheng Deng, Hideaki Hayashi, Hajime Nagahara

Automatic facial expression spotting, which aims to identify facial expression instances in untrimmed videos, is crucial for facial expression analysis. Existing methods primarily focus on fully-supervised learning and rely on costly, time-consuming temporal boundary annotations. In this paper, we investigate point-supervised facial expression spotting (P-FES), where only a single timestamp annotation per instance is required for training. We propose a unique two-branch framework for P-FES. First, to mitigate the limitation of hard pseudo-labeling, which often confuses neutral and expression frames with various intensities, we propose a Gaussian-based instance-adaptive intensity modeling (GIM) module to model instance-level expression intensity distribution for soft pseudo-labeling. By detecting the pseudo-apex frame around each point label, estimating the duration, and constructing an instance-level Gaussian distribution, GIM assigns soft pseudo-labels to expression frames for more reliable intensity supervision. The GIM module is incorporated into our framework to optimize the class-agnostic expression intensity branch. Second, we design a class-aware apex classification branch that distinguishes macro- and micro-expressions solely based on their pseudo-apex frames. During inference, the two branches work independently: the class-agnostic expression intensity branch generates expression proposals, while the class-aware apex-classification branch is responsible for macro- and micro-expression classification. Furthermore, we introduce an intensity-aware contrastive loss to enhance discriminative feature learning and suppress neutral noise by contrasting neutral frames with expression frames with various intensities. Extensive experiments on the SAMM-LV, CAS(ME)$^2$, and CAS(ME)$^3$ datasets demonstrate the effectiveness of our proposed framework.

Masahito Toba, Seiichi Uchida, Hideaki Hayashi

In pseudo-labeling (PL), which is a type of semi-supervised learning, pseudo-labels are assigned based on the confidence scores provided by the classifier; therefore, accurate confidence is important for successful PL. In this study, we propose a PL algorithm based on an energy-based model (EBM), which is referred to as the energy-based PL (EBPL). In EBPL, a neural network-based classifier and an EBM are jointly trained by sharing their feature extraction parts. This approach enables the model to learn both the class decision boundary and input data distribution, enhancing confidence calibration during network training. The experimental results demonstrate that EBPL outperforms the existing PL method in semi-supervised image classification tasks, with superior confidence calibration error and recognition accuracy.

Hideaki Hayashi

Generative models have advantageous characteristics for classification tasks such as the availability of unsupervised data and calibrated confidence, whereas discriminative models have advantages in terms of the simplicity of their model structures and learning algorithms and their ability to outperform their generative counterparts. In this paper, we propose a method to train a hybrid of discriminative and generative models in a single neural network (NN), which exhibits the characteristics of both models. The key idea is the Gaussian-coupled softmax layer, which is a fully connected layer with a softmax activation function coupled with Gaussian distributions. This layer can be embedded into an NN-based classifier and allows the classifier to estimate both the class posterior distribution and the class-conditional data distribution. We demonstrate that the proposed hybrid model can be applied to semi-supervised learning and confidence calibration.

Shota Harada, Ryoma Bise, Hideaki Hayashi et al.

Ulcerative colitis (UC) classification, which is an important task for endoscopic diagnosis, involves two main difficulties. First, endoscopic images with the annotation about UC (positive or negative) are usually limited. Second, they show a large variability in their appearance due to the location in the colon. Especially, the second difficulty prevents us from using existing semi-supervised learning techniques, which are the common remedy for the first difficulty. In this paper, we propose a practical semi-supervised learning method for UC classification by newly exploiting two additional features, the location in a colon (e.g., left colon) and image capturing order, both of which are often attached to individual images in endoscopic image sequences. The proposed method can extract the essential information of UC classification efficiently by a disentanglement process with those features. Experimental results demonstrate that the proposed method outperforms several existing semi-supervised learning methods in the classification task, even with a small number of annotated images.

Takato Otsuzuki, Heon Song, Seiichi Uchida et al.

In convolutional neural network-based character recognition, pooling layers play an important role in dimensionality reduction and deformation compensation. However, their kernel shapes and pooling operations are empirically predetermined; typically, a fixed-size square kernel shape and max pooling operation are used. In this paper, we propose a meta-learning framework for pooling layers. As part of our framework, a parameterized pooling layer is proposed in which the kernel shape and pooling operation are trainable using two parameters, thereby allowing flexible pooling of the input data. We also propose a meta-learning algorithm for the parameterized pooling layer, which allows us to acquire a suitable pooling layer across multiple tasks. In the experiment, we applied the proposed meta-learning framework to character recognition tasks. The results demonstrate that a pooling layer that is suitable across character recognition tasks was obtained via meta-learning, and the obtained pooling layer improved the performance of the model in both few-shot character recognition and noisy image recognition tasks.

Shohei Kubota, Hideaki Hayashi, Tomohiro Hayase et al.

The interpretability of neural networks (NNs) is a challenging but essential topic for transparency in the decision-making process using machine learning. One of the reasons for the lack of interpretability is random weight initialization, where the input is randomly embedded into a different feature space in each layer. In this paper, we propose an interpretation method for a deep multilayer perceptron, which is the most general architecture of NNs, based on identity initialization (namely, initialization using identity matrices). The proposed method allows us to analyze the contribution of each neuron to classification and class likelihood in each hidden layer. As a property of the identity-initialized perceptron, the weight matrices remain near the identity matrices even after learning. This property enables us to treat the change of features from the input to each hidden layer as the contribution to classification. Furthermore, we can separate the output of each hidden layer into a contribution map that depicts the contribution to classification and class likelihood, by adding extra dimensions to each layer according to the number of classes, thereby allowing the calculation of the recognition accuracy in each layer and thus revealing the roles of independent layers, such as feature extraction and classification.

Masaki Yamagata, Hideaki Hayashi, Seiichi Uchida

Temporal prediction is a still difficult task due to the chaotic behavior, non-Markovian characteristics, and non-stationary noise of temporal signals. Handwriting prediction is also challenging because of uncertainty arising from inter-class bifurcation structures, in addition to the above problems. For example, the classes '0' and '6' are very similar in terms of their beginning parts; therefore it is nearly impossible to predict their subsequent parts from the beginning part. In other words, '0' and '6' have a bifurcation structure due to ambiguity between classes, and we cannot make a long-term prediction in this context. In this paper, we propose a temporal prediction model that can deal with this bifurcation structure. Specifically, the proposed model learns the bifurcation structure explicitly as a Gaussian mixture model (GMM) for each class as well as the posterior probability of the classes. The final result of prediction is represented as the weighted sum of GMMs using the class probabilities as weights. When multiple classes have large weights, the model can handle a bifurcation and thus avoid an inaccurate prediction. The proposed model is formulated as a neural network including long short-term memories and is thus trained in an end-to-end manner. The proposed model was evaluated on the UNIPEN online handwritten character dataset, and the results show that the model can catch and deal with the bifurcation structures.

Takato Otsuzuki, Hideaki Hayashi, Yuchen Zheng et al.

In convolutional neural networks (CNNs), pooling operations play important roles such as dimensionality reduction and deformation compensation. In general, max pooling, which is the most widely used operation for local pooling, is performed independently for each kernel. However, the deformation may be spatially smooth over the neighboring kernels. This means that max pooling is too flexible to compensate for actual deformations. In other words, its excessive flexibility risks canceling the essential spatial differences between classes. In this paper, we propose regularized pooling, which enables the value selection direction in the pooling operation to be spatially smooth across adjacent kernels so as to compensate only for actual deformations. The results of experiments on handwritten character images and texture images showed that regularized pooling not only improves recognition accuracy but also accelerates the convergence of learning compared with conventional pooling operations.

Hideaki Hayashi, Seiichi Uchida

In probabilistic classification, a discriminative model based on the softmax function has a potential limitation in that it assumes unimodality for each class in the feature space. The mixture model can address this issue, although it leads to an increase in the number of parameters. We propose a sparse classifier based on a discriminative GMM, referred to as a sparse discriminative Gaussian mixture (SDGM). In the SDGM, a GMM-based discriminative model is trained via sparse Bayesian learning. Using this sparse learning framework, we can simultaneously remove redundant Gaussian components and reduce the number of parameters used in the remaining components during learning; this learning method reduces the model complexity, thereby improving the generalization capability. Furthermore, the SDGM can be embedded into neural networks (NNs), such as convolutional NNs, and can be trained in an end-to-end manner. Experimental results demonstrated that the proposed method outperformed the existing softmax-based discriminative models.

Hideaki Hayashi, Taro Shibanoki, Toshio Tsuji

Electromyogram (EMG) classification is a key technique in EMG-based control systems. The existing EMG classification methods do not consider the characteristics of EMG features that the distribution has skewness and kurtosis, causing drawbacks such as the requirement of hyperparameter tuning. In this paper, we propose a neural network based on the Johnson $S_\mathrm{U}$ translation system that is capable of representing distributions with skewness and kurtosis. The Johnson system is a normalizing translation that transforms non-normal data to a normal distribution, thereby enabling the representation of a wide range of distributions. In this study, a discriminative model based on the multivariate Johnson $S_\mathrm{U}$ translation system is transformed into a linear combination of coefficients and input vectors using log-linearization. This is then incorporated into a neural network structure, thereby allowing the calculation of the posterior probability of the input vectors for each class and the determination of model parameters as weight coefficients of the network. The uniqueness of convergence of the network learning is theoretically guaranteed. In the experiments, the suitability of the proposed network for distributions including skewness and kurtosis is evaluated using artificially generated data. Its applicability for real biological data is also evaluated via an EMG classification experiment. The results show that the proposed network achieves high classification performance without the need for hyperparameter optimization.

Hideaki Hayashi, Taro Shibanoki, Keisuke Shima et al.

This paper proposes a probabilistic neural network developed on the basis of time-series discriminant component analysis (TSDCA) that can be used to classify high-dimensional time-series patterns. TSDCA involves the compression of high-dimensional time series into a lower-dimensional space using a set of orthogonal transformations and the calculation of posterior probabilities based on a continuous-density hidden Markov model with a Gaussian mixture model expressed in the reduced-dimensional space. The analysis can be incorporated into a neural network, which is named a time-series discriminant component network (TSDCN), so that parameters of dimensionality reduction and classification can be obtained simultaneously as network coefficients according to a backpropagation through time-based learning algorithm with the Lagrange multiplier method. The TSDCN is considered to enable high-accuracy classification of high-dimensional time-series patterns and to reduce the computation time taken for network training. The validity of the TSDCN is demonstrated for high-dimensional artificial data and EEG signals in the experiments conducted during the study.

Taichi Sumi, Brian Kenji Iwana, Hideaki Hayashi et al.

This research attempts to construct a network that can convert online and offline handwritten characters to each other. The proposed network consists of two Variational Auto-Encoders (VAEs) with a shared latent space. The VAEs are trained to generate online and offline handwritten Latin characters simultaneously. In this way, we create a cross-modal VAE (Cross-VAE). During training, the proposed Cross-VAE is trained to minimize the reconstruction loss of the two modalities, the distribution loss of the two VAEs, and a novel third loss called the space sharing loss. This third, space sharing loss is used to encourage the modalities to share the same latent space by calculating the distance between the latent variables. Through the proposed method mutual conversion of online and offline handwritten characters is possible. In this paper, we demonstrate the performance of the Cross-VAE through qualitative and quantitative analysis.

Changhee Han, Leonardo Rundo, Ryosuke Araki et al.

Convolutional Neural Networks (CNNs) achieve excellent computer-assisted diagnosis with sufficient annotated training data. However, most medical imaging datasets are small and fragmented. In this context, Generative Adversarial Networks (GANs) can synthesize realistic/diverse additional training images to fill the data lack in the real image distribution; researchers have improved classification by augmenting data with noise-to-image (e.g., random noise samples to diverse pathological images) or image-to-image GANs (e.g., a benign image to a malignant one). Yet, no research has reported results combining noise-to-image and image-to-image GANs for further performance boost. Therefore, to maximize the DA effect with the GAN combinations, we propose a two-step GAN-based DA that generates and refines brain Magnetic Resonance (MR) images with/without tumors separately: (i) Progressive Growing of GANs (PGGANs), multi-stage noise-to-image GAN for high-resolution MR image generation, first generates realistic/diverse 256 X 256 images; (ii) Multimodal UNsupervised Image-to-image Translation (MUNIT) that combines GANs/Variational AutoEncoders or SimGAN that uses a DA-focused GAN loss, further refines the texture/shape of the PGGAN-generated images similarly to the real ones. We thoroughly investigate CNN-based tumor classification results, also considering the influence of pre-training on ImageNet and discarding weird-looking GAN-generated images. The results show that, when combined with classic DA, our two-step GAN-based DA can significantly outperform the classic DA alone, in tumor detection (i.e., boosting sensitivity 93.67% to 97.48%) and also in other medical imaging tasks.

Hideaki Hayashi, Seiichi Uchida

In this paper, we propose a trainable multiplication layer (TML) for a neural network that can be used to calculate the multiplication between the input features. Taking an image as an input, the TML raises each pixel value to the power of a weight and then multiplies them, thereby extracting the higher-order local auto-correlation from the input image. The TML can also be used to extract co-occurrence from the feature map of a convolutional network. The training of the TML is formulated based on backpropagation with constraints to the weights, enabling us to learn discriminative multiplication patterns in an end-to-end manner. In the experiments, the characteristics of the TML are investigated by visualizing learned kernels and the corresponding output features. The applicability of the TML for classification and neural network interpretation is also evaluated using public datasets.

Hideaki Hayashi, Kohtaro Abe, Seiichi Uchida

In this paper, we propose GlyphGAN: style-consistent font generation based on generative adversarial networks (GANs). GANs are a framework for learning a generative model using a system of two neural networks competing with each other. One network generates synthetic images from random input vectors, and the other discriminates between synthetic and real images. The motivation of this study is to create new fonts using the GAN framework while maintaining style consistency over all characters. In GlyphGAN, the input vector for the generator network consists of two vectors: character class vector and style vector. The former is a one-hot vector and is associated with the character class of each sample image during training. The latter is a uniform random vector without supervised information. In this way, GlyphGAN can generate an infinite variety of fonts with the character and style independently controlled. Experimental results showed that fonts generated by GlyphGAN have style consistency and diversity different from the training images without losing their legibility.

Kumar Shridhar, Joonho Lee, Hideaki Hayashi et al.

Activation functions play an important role in training artificial neural networks. The majority of currently used activation functions are deterministic in nature, with their fixed input-output relationship. In this work, we propose a novel probabilistic activation function, called ProbAct. ProbAct is decomposed into a mean and variance and the output value is sampled from the formed distribution, making ProbAct a stochastic activation function. The values of mean and variances can be fixed using known functions or trained for each element. In the trainable ProbAct, the mean and the variance of the activation distribution is trained within the back-propagation framework alongside other parameters. We show that the stochastic perturbation induced through ProbAct acts as a viable generalization technique for feature augmentation. In our experiments, we compare ProbAct with well-known activation functions on classification tasks on different modalities: Images(CIFAR-10, CIFAR-100, and STL-10) and Text (Large Movie Review). We show that ProbAct increases the classification accuracy by +2-3% compared to ReLU or other conventional activation functions on both original datasets and when datasets are reduced to 50% and 25% of the original size. Finally, we show that ProbAct learns an ensemble of models by itself that can be used to estimate the uncertainties associated with the prediction and provides robustness to noisy inputs.

Shota Harada, Hideaki Hayashi, Seiichi Uchida

The effectiveness of biosignal generation and data augmentation with biosignal generative models based on generative adversarial networks (GANs), which are a type of deep learning technique, was demonstrated in our previous paper. GAN-based generative models only learn the projection between a random distribution as input data and the distribution of training data.Therefore, the relationship between input and generated data is unclear, and the characteristics of the data generated from this model cannot be controlled. This study proposes a method for generating time-series data based on GANs and explores their ability to generate biosignals with certain classes and characteristics. Moreover, in the proposed method, latent variables are analyzed using canonical correlation analysis (CCA) to represent the relationship between input and generated data as canonical loadings. Using these loadings, we can control the characteristics of the data generated by the proposed method. The influence of class labels on generated data is analyzed by feeding the data interpolated between two class labels into the generator of the proposed GANs. The CCA of the latent variables is shown to be an effective method of controlling the generated data characteristics. We are able to model the distribution of the time-series data without requiring domain-dependent knowledge using the proposed method. Furthermore, it is possible to control the characteristics of these data by analyzing the model trained using the proposed method. To the best of our knowledge, this work is the first to generate biosignals using GANs while controlling the characteristics of the generated data.

Changhee Han, Leonardo Rundo, Ryosuke Araki et al.

Due to the lack of available annotated medical images, accurate computer-assisted diagnosis requires intensive Data Augmentation (DA) techniques, such as geometric/intensity transformations of original images; however, those transformed images intrinsically have a similar distribution to the original ones, leading to limited performance improvement. To fill the data lack in the real image distribution, we synthesize brain contrast-enhanced Magnetic Resonance (MR) images---realistic but completely different from the original ones---using Generative Adversarial Networks (GANs). This study exploits Progressive Growing of GANs (PGGANs), a multi-stage generative training method, to generate original-sized 256 X 256 MR images for Convolutional Neural Network-based brain tumor detection, which is challenging via conventional GANs; difficulties arise due to unstable GAN training with high resolution and a variety of tumors in size, location, shape, and contrast. Our preliminary results show that this novel PGGAN-based DA method can achieve promising performance improvement, when combined with classical DA, in tumor detection and also in other medical imaging tasks.