Xiangjun Zhang

Zhangtianyi Chen, Florensia Widjaja, Wufei Dai et al.

Biomedical agents promise to automate complex biological workflows, yet current systems face two fundamental bottlenecks: bioinformatics tools are highly heterogeneous in interfaces and execution environments, while agent planning still relies on flat prompt-retrieved tool descriptions. As biomedical software ecosystems grow, this coupling between tool coverage and context size leads to tool confusion, unstable planning, and inefficient execution. We introduce BioManus, an MCP-native biomedical agent built on graph-scaffolded planning over structured biological capabilities. BioManus first introduces the BioinfoMCP Compiler, which converts heterogeneous bioinformatics software into standardized MCP servers, yielding a large executable MCP ecosystem. It then organizes this ecosystem as a typed heterogeneous MCP graph over tools, operations, datatypes, and workflow stages. At inference time, BioManus retrieves compact task-specific subgraphs, synthesizes operation-level workflow scaffolds. This design decouples planning complexity from raw tool inventory size, achieving a context compression ratio of Theta(N / (h * m_bar)) under high-recall retrieval, where N is the total tool count, h is the workflow horizon, and m_bar (much smaller than N) is the average number of candidate tools per operation. Experiments on BioAgentBench and LAB-Bench show that BioManus improves execution accuracy, workflow validity, and context efficiency over advanced biomedical agent baselines. This work suggests a paradigm shift: scalable biomedical reasoning requires structured executable capability graphs rather than increasingly larger prompt-level tool retrieval.

Xiangjun Zhang, Litong Gong, Yinglin Zheng et al.

Most text-to-video(T2V) diffusion models depend on pre-trained text encoders for semantic alignment, yet they often fail to maintain video quality when provided with concise prompts rather than well-designed ones. The primary issue lies in their limited textual semantics understanding. Moreover, these text encoders cannot rephrase prompts online to better align with user intentions, which limits both the scalability and usability of the models, To address these challenges, we introduce RISE-T2V, which uniquely integrates the processes of prompt rephrasing and semantic feature extraction into a single and seamless step instead of two separate steps. RISE-T2V is universal and can be applied to various pre-trained LLMs and video diffusion models(VDMs), significantly enhancing their capabilities for T2V tasks. We propose an innovative module called the Rephrasing Adapter, enabling diffusion models to utilize text hidden states during the next token prediction of the LLM as a condition for video generation. By employing a Rephrasing Adapter, the video generation model can implicitly rephrase basic prompts into more comprehensive representations that better match the user's intent. Furthermore, we leverage the powerful capabilities of LLMs to enable video generation models to accomplish a broader range of T2V tasks. Extensive experiments demonstrate that RISE-T2V is a versatile framework applicable to different video diffusion model architectures, significantly enhancing the ability of T2V models to generate high-quality videos that align with user intent. Visual results are available on the webpage at https://rise-t2v.github.io.