Luigi Tommaso Luppino

Santiago Cepeda, Roberto Romero, Daniel Garcia-Perez et al.

Accurately assessing tumor removal is paramount in the management of glioblastoma. We developed a pipeline using MRI scans and neural networks to segment tumor subregions and the surgical cavity in postoperative images. Our model excels in accurately classifying the extent of resection, offering a valuable tool for clinicians in assessing treatment effectiveness.

Klara Leffler, Luigi Tommaso Luppino, Samuel Kuttner et al.

Long axial field-of-view PET scanners offer increased field-of-view and sensitivity compared to traditional PET scanners. However, a significant cost is associated with the densely packed photodetectors required for the extended-coverage systems, limiting clinical utilisation. To mitigate the cost limitations, alternative sparse system configurations have been proposed, allowing an extended field-of-view PET design with detector costs similar to a standard PET system, albeit at the expense of image quality. In this work, we propose a deep sinogram restoration network to fill in the missing sinogram data. Our method utilises a modified Residual U-Net, trained on clinical PET scans from a GE Signa PET/MR, simulating the removal of 50% of the detectors in a chessboard pattern (retaining only 25% of all lines of response). The model successfully recovers missing counts, with a mean absolute error below two events per pixel, outperforming 2D interpolation in both sinogram and reconstructed image domain. Notably, the predicted sinograms exhibit a smoothing effect, leading to reconstructed images lacking sharpness in finer details. Despite these limitations, the model demonstrates a substantial capacity for compensating for the undersampling caused by the sparse detector configuration. This proof-of-concept study suggests that sparse detector configurations, combined with deep learning techniques, offer a viable alternative to conventional PET scanner designs. This approach supports the development of cost-effective, total body PET scanners, allowing a significant step forward in medical imaging technology.

Luigi Tommaso Luppino, Michael Kampffmeyer, Filippo Maria Bianchi et al.

Image translation with convolutional neural networks has recently been used as an approach to multimodal change detection. Existing approaches train the networks by exploiting supervised information of the change areas, which, however, is not always available. A main challenge in the unsupervised problem setting is to avoid that change pixels affect the learning of the translation function. We propose two new network architectures trained with loss functions weighted by priors that reduce the impact of change pixels on the learning objective. The change prior is derived in an unsupervised fashion from relational pixel information captured by domain-specific affinity matrices. Specifically, we use the vertex degrees associated with an absolute affinity difference matrix and demonstrate their utility in combination with cycle consistency and adversarial training. The proposed neural networks are compared with state-of-the-art algorithms. Experiments conducted on three real datasets show the effectiveness of our methodology.

Luigi Tommaso Luppino, Stian Normann Anfinsen, Gabriele Moser et al.

Change detection in heterogeneous multitemporal satellite images is a challenging and still not much studied topic in remote sensing and earth observation. This paper focuses on comparison of image pairs covering the same geographical area and acquired by two different sensors, one optical radiometer and one synthetic aperture radar, at two different times. We propose a clustering-based technique to detect changes, identified as clusters that split or merge in the different images. To evaluate potentials and limitations of our method, we perform experiments on real data. Preliminary results confirm the relationship between splits and merges of clusters and the occurrence of changes. However, it becomes evident that it is necessary to incorporate prior, ancillary, or application-specific information to improve the interpretation of clustering results and to identify unambiguously the areas of change.