Zhengwei Xie

Zhisheng Chen, Tingyu Wu, Zijie Zhou et al.

Memory is not merely a storage mechanism for intelligent systems, but a structure for organizing evidence and constraining belief. This is especially important for multimodal reasoning, where retrieved evidence must be both query-relevant and visually consistent. However, current memory systems for vision-language models (VLMs) remain largely positive-associative: they retrieve what is similar or previously observed, but lack an explicit way to remember what has been verified as absent or logically excluded. To this end, we propose \textbf{PolarMem}, a training-free polarized latent graph memory framework for verifiable vision-language reasoning. PolarMem transforms frozen VLM perceptual signals into \textit{HAS}, \textit{NOT\_HAS}, and \textit{Uncertain} memory states through semantic consistency verification and adaptive distributional partitioning, and stores them in a polarized graph with distinct positive and negative memory relations. During inference, a lexicographical logic-aware retrieval protocol enforces logical consistency before semantic similarity, suppressing conflicting memories before they enter the model context. Across eight frozen VLM backbones and six multimodal benchmarks, PolarMem consistently improves retrieval-intensive tasks and reduces retrieval-level contradictions. These results highlight negative memory as a key mechanism for building more reliable multimodal memory systems. Our code is available at https://github.com/czs-ict/PolarMem.

Lisheng Zhang, Lilong Wang, Xiangyu Sun et al.

Computational drug discovery, particularly the complex workflows of drug molecule screening and optimization, requires orchestrating dozens of specialized tools in multi-step workflows, yet current AI agents struggle to maintain robust performance and consistently underperform in these high-complexity scenarios. Here we present MolClaw, an autonomous agent that leads drug molecule evaluation, screening, and optimization. It unifies over 30 specialized domain resources through a three-tier hierarchical skill architecture (70 skills in total) that facilitates agent long-term interaction at runtime: tool-level skills standardize atomic operations, workflow-level skills compose them into validated pipelines with quality check and reflection, and a discipline-level skill supplies scientific principles governing planning and verification across all scenarios in the field. Additionally, we introduce MolBench, a benchmark comprising molecular screening, optimization, and end-to-end discovery challenges spanning 8 to 50+ sequential tool calls. MolClaw achieves state-of-the-art performance across all metrics, and ablation studies confirm that gains concentrate on tasks that demand structured workflows while vanishing on those solvable with ad hoc scripting, establishing workflow orchestration competence as the primary capability bottleneck for AI-driven drug discovery.

Zhengwei Xie, Zhisheng Chen, Ziyan Weng et al.

Open-world embodied agents must solve long-horizon tasks where the main bottleneck is not single-step planning quality but how interaction experience is organized and evolved. To this end, we present Steve-Evolving, a non-parametric self-evolving framework that tightly couples fine-grained execution diagnosis with dual-track knowledge distillation in a closed loop. The method follows three phases: Experience Anchoring, Experience Distillation, and Knowledge-Driven Closed-Loop Control. In detail, Experience Anchoring solidifies each subgoal attempt into a structured experience tuple with a fixed schema (pre-state, action, diagnosis-result, and post-state) and organizes it in a three-tier experience space with multi-dimensional indices (e.g., condition signatures, spatial hashing, and semantic tags) plus rolling summarization for efficient and auditable recall. To ensure sufficient information density for attribution, the execution layer provides compositional diagnosis signals beyond binary outcomes, including state-difference summaries, enumerated failure causes, continuous indicators, and stagnation/loop detection. Moreover, successful trajectories of Experience Distillation are generalized into reusable skills with explicit preconditions and verification criteria, while failures are distilled into executable guardrails that capture root causes and forbid risky operations at both subgoal and task granularities. Besides, Knowledge-Driven Closed-Loop Control retrieved skills and guardrails are injected into an LLM planner, and diagnosis-triggered local replanning updates the active constraints online, forming a continual evolution process without any model parameter updates. Experiments on the long-horizon suite of Minecraft MCU demonstrate consistent improvements over static-retrieval baselines.

Weikaixin Kong, Xinyu Tu, Zhengwei Xie et al.

We used machine learning methods to predict NaV1.7 inhibitors and found the model RF-CDK that performed best on the imbalanced dataset. Using the RF-CDK model for screening drugs, we got effective compounds K1. We use the cell patch clamp method to verify K1. However, because the model evaluation method in this article is not comprehensive enough, there is still a lot of research work to be performed, such as comparison with other existing methods. The target protein has multiple active sites and requires our further research. We need more detailed models to consider this biological process and compare it with the current results, which is an error in this article. So we want to withdraw this article.