Stelios Mylonas

h-index8
2papers
279citations

2 Papers

3.6CVAug 27, 2025
Improving Generalization in Deepfake Detection with Face Foundation Models and Metric Learning

Stelios Mylonas, Symeon Papadopoulos

The increasing realism and accessibility of deepfakes have raised critical concerns about media authenticity and information integrity. Despite recent advances, deepfake detection models often struggle to generalize beyond their training distributions, particularly when applied to media content found in the wild. In this work, we present a robust video deepfake detection framework with strong generalization that takes advantage of the rich facial representations learned by face foundation models. Our method is built on top of FSFM, a self-supervised model trained on real face data, and is further fine-tuned using an ensemble of deepfake datasets spanning both face-swapping and face-reenactment manipulations. To enhance discriminative power, we incorporate triplet loss variants during training, guiding the model to produce more separable embeddings between real and fake samples. Additionally, we explore attribution-based supervision schemes, where deepfakes are categorized by manipulation type or source dataset, to assess their impact on generalization. Extensive experiments across diverse evaluation benchmarks demonstrate the effectiveness of our approach, especially in challenging real-world scenarios.

9.7BMFeb 13, 2020Code
DeepSurf: A surface-based deep learning approach for the prediction of ligand binding sites on proteins

Stelios K. Mylonas, Apostolos Axenopoulos, Petros Daras

The knowledge of potentially druggable binding sites on proteins is an important preliminary step towards the discovery of novel drugs. The computational prediction of such areas can be boosted by following the recent major advances in the deep learning field and by exploiting the increasing availability of proper data. In this paper, a novel computational method for the prediction of potential binding sites is proposed, called DeepSurf. DeepSurf combines a surface-based representation, where a number of 3D voxelized grids are placed on the protein's surface, with state-of-the-art deep learning architectures. After being trained on the large database of scPDB, DeepSurf demonstrates superior results on three diverse testing datasets, by surpassing all its main deep learning-based competitors, while attaining competitive performance to a set of traditional non-data-driven approaches.