Diedre Carmo

Diedre Carmo, Leticia Rittner, Roberto Lotufo

Airway segmentation in computed tomography images can be used to analyze pulmonary diseases, however, manual segmentation is labor intensive and relies on expert knowledge. This manuscript details our contribution to MICCAI's 2022 Airway Tree Modelling challenge, a competition of fully automated methods for airway segmentation. We employed a previously developed deep learning architecture based on a modified EfficientDet (MEDSeg), training from scratch for binary airway segmentation using the provided annotations. Our method achieved 90.72 Dice in internal validation, 95.52 Dice on external validation, and 93.49 Dice in the final test phase, while not being specifically designed or tuned for airway segmentation. Open source code and a pip package for predictions with our model and trained weights are in https://github.com/MICLab-Unicamp/medseg.

Diedre Carmo, Gustavo Pinheiro, Lívia Rodrigues et al.

Medical image segmentation is an increasingly popular area of research in medical imaging processing and analysis. However, many researchers who are new to the field struggle with basic concepts. This tutorial paper aims to provide an overview of the fundamental concepts of medical imaging, with a focus on Magnetic Resonance and Computerized Tomography. We will also discuss deep learning algorithms, tools, and frameworks used for segmentation tasks, and suggest best practices for method development and image analysis. Our tutorial includes sample tasks using public data, and accompanying code is available on GitHub (https://github.com/MICLab-Unicamp/Medical-ImagingTutorial). By sharing our insights gained from years of experience in the field and learning from relevant literature, we hope to assist researchers in overcoming the initial challenges they may encounter in this exciting and important area of research.

Diedre S. Carmo, Rosarie A. Tudas, Alejandro P. Comellas et al.

Automated segmentation of lung abnormalities in computed tomography is an important step for diagnosing and characterizing lung disease. In this work, we improve upon a previous method and propose S-MEDSeg, a deep learning based approach for accurate segmentation of lung lesions in chest CT images. S-MEDSeg combines a pre-trained EfficientNet backbone, bidirectional feature pyramid network, and modern network advancements to achieve improved segmentation performance. A comprehensive ablation study was performed to evaluate the contribution of the proposed network modifications. The results demonstrate modifications introduced in S-MEDSeg significantly improves segmentation performance compared to the baseline approach. The proposed method is applied to an independent dataset of long COVID inpatients to study the effect of post-acute infection vaccination on extent of lung findings. Open-source code, graphical user interface and pip package are available at https://github.com/MICLab-Unicamp/medseg.

Mateus Oliveira da Silva, Caio Pinheiro Santana, Diedre Santos do Carmo et al.

Identifying and characterizing brain fiber bundles can help to understand many diseases and conditions. An important step in this process is the estimation of fiber orientations using Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI). However, obtaining robust orientation estimates demands high-resolution data, leading to lengthy acquisitions that are not always clinically available. In this work, we explore the use of automated angular super resolution from faster acquisitions to overcome this challenge. Using the publicly available Human Connectome Project (HCP) DW-MRI data, we trained a transformer-based deep learning architecture to achieve angular super resolution in fiber orientation distribution (FOD). Our patch-based methodology, FOD-Swin-Net, is able to bring a single-shell reconstruction driven from 32 directions to be comparable to a multi-shell 288 direction FOD reconstruction, greatly reducing the number of required directions on initial acquisition. Evaluations of the reconstructed FOD with Angular Correlation Coefficient and qualitative visualizations reveal superior performance than the state-of-the-art in HCP testing data. Open source code for reproducibility is available at https://github.com/MICLab-Unicamp/FOD-Swin-Net.

Diedre S. Carmo, Jean A. Ribeiro, Alejandro P. Comellas et al.

The COVID-19 pandemic response highlighted the potential of deep learning methods in facilitating the diagnosis, prognosis and understanding of lung diseases through automated segmentation of pulmonary structures and lesions in chest computed tomography (CT). Automated separation of lung lesion into ground-glass opacity (GGO) and consolidation is hindered due to the labor-intensive and subjective nature of this task, resulting in scarce availability of ground truth for supervised learning. To tackle this problem, we propose MEDPSeg. MEDPSeg learns from heterogeneous chest CT targets through hierarchical polymorphic multitask learning (HPML). HPML explores the hierarchical nature of GGO and consolidation, lung lesions, and the lungs, with further benefits achieved through multitasking airway and pulmonary artery segmentation. Over 6000 volumetric CT scans from different partially labeled sources were used for training and testing. Experiments show PML enabling new state-of-the-art performance for GGO and consolidation segmentation tasks. In addition, MEDPSeg simultaneously performs segmentation of the lung parenchyma, airways, pulmonary artery, and lung lesions, all in a single forward prediction, with performance comparable to state-of-the-art methods specialized in each of those targets. Finally, we provide an open-source implementation with a graphical user interface at https://github.com/MICLab-Unicamp/medpseg.

Juvenal Domingos Júnior, Augusto Faria, E. Seiti de Oliveira et al.

This paper presents BR-TaxQA-R, a novel dataset designed to support question answering with references in the context of Brazilian personal income tax law. The dataset contains 715 questions from the 2024 official Q\&A document published by Brazil's Internal Revenue Service, enriched with statutory norms and administrative rulings from the Conselho Administrativo de Recursos Fiscais (CARF). We implement a Retrieval-Augmented Generation (RAG) pipeline using OpenAI embeddings for searching and GPT-4o-mini for answer generation. We compare different text segmentation strategies and benchmark our system against commercial tools such as ChatGPT and Perplexity.ai using RAGAS-based metrics. Results show that our custom RAG pipeline outperforms commercial systems in Response Relevancy, indicating stronger alignment with user queries, while commercial models achieve higher scores in Factual Correctness and fluency. These findings highlight a trade-off between legally grounded generation and linguistic fluency. Crucially, we argue that human expert evaluation remains essential to ensure the legal validity of AI-generated answers in high-stakes domains such as taxation. BR-TaxQA-R is publicly available at https://huggingface.co/datasets/unicamp-dl/BR-TaxQA-R.

Diedre Carmo, Marcos Piau, Israel Campiotti et al.

In natural language processing (NLP), there is a need for more resources in Portuguese, since much of the data used in the state-of-the-art research is in other languages. In this paper, we pretrain a T5 model on the BrWac corpus, an extensive collection of web pages in Portuguese, and evaluate its performance against other Portuguese pretrained models and multilingual models on three different tasks. We show that our Portuguese pretrained models have significantly better performance over the original T5 models. Moreover, we demonstrate the positive impact of using a Portuguese vocabulary. Our code and models are available at https://github.com/unicamp-dl/PTT5.

Diedre Carmo, Bruna Silva, Clarissa Yasuda et al.

Hippocampus segmentation plays a key role in diagnosing various brain disorders such as Alzheimer's disease, epilepsy, multiple sclerosis, cancer, depression and others. Nowadays, segmentation is still mainly performed manually by specialists. Segmentation done by experts is considered to be a gold-standard when evaluating automated methods, buts it is a time consuming and arduos task, requiring specialized personnel. In recent years, efforts have been made to achieve reliable automated segmentation. For years the best performing authomatic methods were multi atlas based with around 80-85% Dice coefficient and very time consuming, but machine learning methods are recently rising with promising time and accuracy performance. A method for volumetric hippocampus segmentation is presented, based on the consensus of tri-planar U-Net inspired fully convolutional networks (FCNNs), with some modifications, including residual connections, VGG weight transfers, batch normalization and a patch extraction technique employing data from neighbor patches. A study on the impact of our modifications to the classical U-Net architecture was performed. Our method achieves cutting edge performance in our dataset, with around 96% volumetric Dice accuracy in our test data. In a public validation dataset, HARP, we achieve 87.48% DICE. GPU execution time is in the order of seconds per volume, and source code is publicly available. Also, masks are shown to be similar to other recent state-of-the-art hippocampus segmentation methods in a third dataset, without manual annotations.