Sharlene D. Newman

Shreyas Fadnavis, Hamza Farooq, Maryam Afzali et al.

Fitting multi-exponential models to Diffusion MRI (dMRI) data has always been challenging due to various underlying complexities. In this work, we introduce a novel and robust fitting framework for the standard two-compartment IVIM microstructural model. This framework provides a significant improvement over the existing methods and helps estimate the associated diffusion and perfusion parameters of IVIM in an automatic manner. As a part of this work we provide capabilities to switch between more advanced global optimization methods such as simplicial homology (SH) and differential evolution (DE). Our experiments show that the results obtained from this simultaneous fitting procedure disentangle the model parameters in a reduced subspace. The proposed framework extends the seminal work originated in the MIX framework, with improved procedures for multi-stage fitting. This framework has been made available as an open-source Python implementation and disseminated to the community through the DIPY project.

Abdullah Alchihabi, Omer Ekmekci, Baran B. Kivilcim et al.

Complex problem solving is a high level cognitive process which has been thoroughly studied over the last decade. The Tower of London (TOL) is a task that has been widely used to study problem-solving. In this study, we aim to explore the underlying cognitive network dynamics among anatomical regions of complex problem solving and its sub-phases, namely planning and execution. A new brain network construction model establishing dynamic functional brain networks using fMRI is proposed. The first step of the model is a preprocessing pipeline that manages to decrease the spatial redundancy while increasing the temporal resolution of the fMRI recordings. Then, dynamic brain networks are estimated using artificial neural networks. The network properties of the estimated brain networks are studied in order to identify regions of interest, such as hubs and subgroups of densely connected brain regions. The major similarities and dissimilarities of the network structure of planning and execution phases are highlighted. Our findings show the hubs and clusters of densely interconnected regions during both subtasks. It is observed that there are more hubs during the planning phase compared to the execution phase, and the clusters are more strongly connected during planning compared to execution.