MEDec 16, 2019
Projection Pursuit with Applications to scRNA Sequencing DataElvis Han Cui, Heather Zhou
In this paper, we explore the limitations of PCA as a dimension reduction technique and study its extension, projection pursuit (PP), which is a broad class of linear dimension reduction methods. We first discuss the relevant concepts and theorems and then apply PCA and PP (with negative standardized Shannon's entropy as the projection index) on single cell RNA sequencing data.