Jeremy Debattista

Lizzy Farrugia, Lilian M. Azzopardi, Jeremy Debattista et al.

In the last decades, people have been consuming and combining more drugs than before, increasing the number of Drug-Drug Interactions (DDIs). To predict unknown DDIs, recently, studies started incorporating Knowledge Graphs (KGs) since they are able to capture the relationships among entities providing better drug representations than using a single drug property. In this paper, we propose the medicX end-to-end framework that integrates several drug features from public drug repositories into a KG and embeds the nodes in the graph using various translation, factorisation and Neural Network (NN) based KG Embedding (KGE) methods. Ultimately, we use a Machine Learning (ML) algorithm that predicts unknown DDIs. Among the different translation and factorisation-based KGE models, we found that the best performing combination was the ComplEx embedding method with a Long Short-Term Memory (LSTM) network, which obtained an F1-score of 95.19% on a dataset based on the DDIs found in DrugBank version 5.1.8. This score is 5.61% better than the state-of-the-art model DeepDDI. Additionally, we also developed a graph auto-encoder model that uses a Graph Neural Network (GNN), which achieved an F1-score of 91.94%. Consequently, GNNs have demonstrated a stronger ability to mine the underlying semantics of the KG than the ComplEx model, and thus using higher dimension embeddings within the GNN can lead to state-of-the-art performance.

Lizzy Farrugia, Lilian M. Azzopardi, Jeremy Debattista et al.

The role of pharmacists is evolving from medicine dispensing to delivering comprehensive pharmaceutical services within multidisciplinary healthcare teams. Central to this shift is access to accurate, up-to-date medicinal product information supported by robust data integration. Leveraging artificial intelligence and semantic technologies, Knowledge Graphs (KGs) uncover hidden relationships and enable data-driven decision-making. This paper presents medicX-KG, a pharmacist-oriented knowledge graph supporting clinical and regulatory decisions. It forms the semantic layer of the broader medicX platform, powering predictive and explainable pharmacy services. medicX-KG integrates data from three sources, including, the British National Formulary (BNF), DrugBank, and the Malta Medicines Authority (MMA) that addresses Malta's regulatory landscape and combines European Medicines Agency alignment with partial UK supply dependence. The KG tackles the absence of a unified national drug repository, reducing pharmacists' reliance on fragmented sources. Its design was informed by interviews with practicing pharmacists to ensure real-world applicability. We detail the KG's construction, including data extraction, ontology design, and semantic mapping. Evaluation demonstrates that medicX-KG effectively supports queries about drug availability, interactions, adverse reactions, and therapeutic classes. Limitations, including missing detailed dosage encoding and real-time updates, are discussed alongside directions for future enhancements.

Nicholas Bonello, Joeran Beel, Seamus Lawless et al.

Fantasy Premier League (FPL) performance predictors tend to base their algorithms purely on historical statistical data. The main problems with this approach is that external factors such as injuries, managerial decisions and other tournament match statistics can never be factored into the final predictions. In this paper, we present a new method for predicting future player performances by automatically incorporating human feedback into our model. Through statistical data analysis such as previous performances, upcoming fixture difficulty ratings, betting market analysis, opinions of the general-public and experts alike via social media and web articles, we can improve our understanding of who is likely to perform well in upcoming matches. When tested on the English Premier League 2018/19 season, the model outperformed regular statistical predictors by over 300 points, an average of 11 points per week, ranking within the top 0.5% of players rank 30,000 out of over 6.5 million players.

Alan Tygel, Sören Auer, Jeremy Debattista et al.

This paper presents an approach for metadata reconciliation, curation and linking for Open Governamental Data Portals (ODPs). ODPs have been lately the standard solution for governments willing to put their public data available for the society. Portal managers use several types of metadata to organize the datasets, one of the most important ones being the tags. However, the tagging process is subject to many problems, such as synonyms, ambiguity or incoherence, among others. As our empiric analysis of ODPs shows, these issues are currently prevalent in most ODPs and effectively hinders the reuse of Open Data. In order to address these problems, we develop and implement an approach for tag reconciliation in Open Data Portals, encompassing local actions related to individual portals, and global actions for adding a semantic metadata layer above individual portals. The local part aims to enhance the quality of tags in a single portal, and the global part is meant to interlink ODPs by establishing relations between tags.

Jeremy Debattista, Christoph Lange, Sören Auer

With the increasing adoption and growth of the Linked Open Data cloud [9], with RDFa, Microformats and other ways of embedding data into ordinary Web pages, and with initiatives such as schema.org, the Web is currently being complemented with a Web of Data. Thus, the Web of Data shares many characteristics with the original Web of Documents, which also varies in quality. This heterogeneity makes it challenging to determine the quality of the data published on the Web and to subsequently make this information explicit to data consumers. The main contribution of this article is LUZZU, a quality assessment framework for Linked Open Data. Apart from providing quality metadata and quality problem reports that can be used for data cleaning, LUZZU is extensible: third party metrics can be easily plugged-in the framework. The framework does not rely on SPARQL endpoints, and is thus free of all the problems that come with them, such as query timeouts. Another advantage over SPARQL based qual- ity assessment frameworks is that metrics implemented in LUZZU can have more complex functionality than triple matching. Using the framework, we performed a quality assessment of a number of statistical linked datasets that are available on the LOD cloud. For this evaluation, 25 metrics from ten different dimensions were implemented.