Steve Tsham Mpinda Ataky

Steve Tsham Mpinda Ataky, Alessandro Lameiras Koerich

Breast cancer is a health problem that affects mainly the female population. An early detection increases the chances of effective treatment, improving the prognosis of the disease. In this regard, computational tools have been proposed to assist the specialist in interpreting the breast digital image exam, providing features for detecting and diagnosing tumors and cancerous cells. Nonetheless, detecting tumors with a high sensitivity rate and reducing the false positives rate is still challenging. Texture descriptors have been quite popular in medical image analysis, particularly in histopathologic images (HI), due to the variability of both the texture found in such images and the tissue appearance due to irregularity in the staining process. Such variability may exist depending on differences in staining protocol such as fixation, inconsistency in the staining condition, and reagents, either between laboratories or in the same laboratory. Textural feature extraction for quantifying HI information in a discriminant way is challenging given the distribution of intrinsic properties of such images forms a non-deterministic complex system. This paper proposes a method for characterizing texture across HIs with a considerable success rate. By employing ecological diversity measures and discrete wavelet transform, it is possible to quantify the intrinsic properties of such images with promising accuracy on two HI datasets compared with state-of-the-art methods.

Steve Tsham Mpinda Ataky, Alessandro Lameiras Koerich

Texture can be defined as the change of image intensity that forms repetitive patterns, resulting from physical properties of the object's roughness or differences in a reflection on the surface. Considering that texture forms a complex system of patterns in a non-deterministic way, biodiversity concepts can help texture characterization in images. This paper proposes a novel approach capable of quantifying such a complex system of diverse patterns through species diversity and richness and taxonomic distinctiveness. The proposed approach considers each image channel as a species ecosystem and computes species diversity and richness measures as well as taxonomic measures to describe the texture. The proposed approach takes advantage of ecological patterns' invariance characteristics to build a permutation, rotation, and translation invariant descriptor. Experimental results on three datasets of natural texture images and two datasets of histopathological images have shown that the proposed texture descriptor has advantages over several texture descriptors and deep methods.

Jonathan de Matos, Steve Tsham Mpinda Ataky, Alceu de Souza Britto et al.

Histopathological images (HIs) are the gold standard for evaluating some types of tumors for cancer diagnosis. The analysis of such images is not only time and resource consuming, but also very challenging even for experienced pathologists, resulting in inter- and intra-observer disagreements. One of the ways of accelerating such an analysis is to use computer-aided diagnosis (CAD) systems. In this paper, we present a review on machine learning methods for histopathological image analysis, including shallow and deep learning methods. We also cover the most common tasks in HI analysis, such as segmentation and feature extraction. In addition, we present a list of publicly available and private datasets that have been used in HI research.

Steve Tsham Mpinda Ataky, Jonathan de Matos, Alceu de S. Britto et al.

Data imbalance is a major problem that affects several machine learning (ML) algorithms. Such a problem is troublesome because most of the ML algorithms attempt to optimize a loss function that does not take into account the data imbalance. Accordingly, the ML algorithm simply generates a trivial model that is biased toward predicting the most frequent class in the training data. In the case of histopathologic images (HIs), both low-level and high-level data augmentation (DA) techniques still present performance issues when applied in the presence of inter-patient variability; whence the model tends to learn color representations, which is related to the staining process. In this paper, we propose a novel approach capable of not only augmenting HI dataset but also distributing the inter-patient variability by means of image blending using the Gaussian-Laplacian pyramid. The proposed approach consists of finding the Gaussian pyramids of two images of different patients and finding the Laplacian pyramids thereof. Afterwards, the left-half side and the right-half side of different HIs are joined in each level of the Laplacian pyramid, and from the joint pyramids, the original image is reconstructed. This composition combines the stain variation of two patients, avoiding that color differences mislead the learning process. Experimental results on the BreakHis dataset have shown promising gains vis-a-vis the majority of DA techniques presented in the literature.