Shihan Zhao

Shihan Zhao, Jianru Zhang, Yanan Wu et al.

Fluorescence Molecular Tomography (FMT) is a promising technique for non-invasive 3D visualization of fluorescent probes, but its reconstruction remains challenging due to the inherent ill-posedness and reliance on inaccurate or often-unknown tissue optical properties. While deep learning methods have shown promise, their supervised nature limits generalization beyond training data. To address these problems, we propose $μ$NeuFMT, a self-supervised FMT reconstruction framework that integrates implicit neural-based scene representation with explicit physical modeling of photon propagation. Its key innovation lies in jointly optimize both the fluorescence distribution and the optical properties ($μ$) during reconstruction, eliminating the need for precise prior knowledge of tissue optics or pre-conditioned training data. We demonstrate that $μ$NeuFMT robustly recovers accurate fluorophore distributions and optical coefficients even with severely erroneous initial values (0.5$\times$ to 2$\times$ of ground truth). Extensive numerical, phantom, and in vivo validations show that $μ$NeuFMT outperforms conventional and supervised deep learning approaches across diverse heterogeneous scenarios. Our work establishes a new paradigm for robust and accurate FMT reconstruction, paving the way for more reliable molecular imaging in complex clinically related scenarios, such as fluorescence guided surgery.

Siddharth Srikanth, Freddie Liang, Sophie Hsu et al.

Vision-Language-Action (VLA) models have significant potential to enable general-purpose robotic systems for a range of vision-language tasks. However, the performance of VLA-based robots is highly sensitive to the precise wording of language instructions, and it remains difficult to predict when such robots will fail. To improve the robustness of VLAs to different wordings, we present Q-DIG (Quality Diversity for Diverse Instruction Generation), which performs red-teaming by scalably identifying diverse natural language task descriptions that induce failures while remaining task-relevant. Q-DIG integrates Quality Diversity (QD) techniques with Vision-Language Models (VLMs) to generate a broad spectrum of adversarial instructions that expose meaningful vulnerabilities in VLA behavior. Our results across multiple simulation benchmarks show that Q-DIG finds more diverse and meaningful failure modes compared to baseline methods, and that fine-tuning VLAs on the generated instructions improves task success rates. Furthermore, results from a user study highlight that Q-DIG generates prompts judged to be more natural and human-like than those from baselines. Finally, real-world evaluations of Q-DIG prompts show results consistent with simulation, and fine-tuning VLAs on the generated prompts further success rates on unseen instructions. Together, these findings suggest that Q-DIG is a promising approach for identifying vulnerabilities and improving the robustness of VLA-based robots. Our anonymous project website is at qdigvla.github.io.