Mike Angstadt

Ruixuan Deng, Xiaoyang Hu, Miles Gilberti et al.

We identify semantically coherent, context-consistent network components in large language models (LLMs) using coactivation of sparse autoencoder (SAE) features collected from just a handful of prompts. Focusing on concept-relation prediction tasks, we show that ablating these components for concepts (e.g., countries and words) and relations (e.g., capital city and translation language) changes model outputs in predictable ways, while amplifying these components induces counterfactual responses. Notably, composing relation and concept components yields compound counterfactual outputs. Further analysis reveals that while most concept components emerge from the very first layer, more abstract relation components are concentrated in later layers. Lastly, we show that extracted components more comprehensively capture concepts and relations than individual features while maintaining specificity. Overall, our findings suggest a modular organization of knowledge accessed through compositional operations, and advance methods for efficient, targeted LLM manipulation.

Pascal Sturmfels, Saige Rutherford, Mike Angstadt et al.

Given the wide success of convolutional neural networks (CNNs) applied to natural images, researchers have begun to apply them to neuroimaging data. To date, however, exploration of novel CNN architectures tailored to neuroimaging data has been limited. Several recent works fail to leverage the 3D structure of the brain, instead treating the brain as a set of independent 2D slices. Approaches that do utilize 3D convolutions rely on architectures developed for object recognition tasks in natural 2D images. Such architectures make assumptions about the input that may not hold for neuroimaging. For example, existing architectures assume that patterns in the brain exhibit translation invariance. However, a pattern in the brain may have different meaning depending on where in the brain it is located. There is a need to explore novel architectures that are tailored to brain images. We present two simple modifications to existing CNN architectures based on brain image structure. Applied to the task of brain age prediction, our network achieves a mean absolute error (MAE) of 1.4 years and trains 30% faster than a CNN baseline that achieves a MAE of 1.6 years. Our results suggest that lessons learned from developing models on natural images may not directly transfer to neuroimaging tasks. Instead, there remains a large space of unexplored questions regarding model development in this area, whose answers may differ from conventional wisdom.