Yuxin Du

Yuxin Du, Fan Bai, Tiejun Huang et al.

Precise image segmentation provides clinical study with instructive information. Despite the remarkable progress achieved in medical image segmentation, there is still an absence of a 3D foundation segmentation model that can segment a wide range of anatomical categories with easy user interaction. In this paper, we propose a 3D foundation segmentation model, named SegVol, supporting universal and interactive volumetric medical image segmentation. By scaling up training data to 90K unlabeled Computed Tomography (CT) volumes and 6K labeled CT volumes, this foundation model supports the segmentation of over 200 anatomical categories using semantic and spatial prompts. To facilitate efficient and precise inference on volumetric images, we design a zoom-out-zoom-in mechanism. Extensive experiments on 22 anatomical segmentation tasks verify that SegVol outperforms the competitors in 19 tasks, with improvements up to 37.24% compared to the runner-up methods. We demonstrate the effectiveness and importance of specific designs by ablation study. We expect this foundation model can promote the development of volumetric medical image analysis. The model and code are publicly available at: https://github.com/BAAI-DCAI/SegVol.

Changwei Wu, Yifei Chen, Yuxin Du et al.

Reliable anomaly detection in brain MRI remains challenging due to the scarcity of annotated abnormal cases and the frequent absence of key imaging modalities in real clinical workflows. Existing single-class or multi-class anomaly detection (AD) models typically rely on fixed modality configurations, require repetitive training, or fail to generalize to unseen modality combinations, limiting their clinical scalability. In this work, we present a unified Any-Modality AD framework that performs robust anomaly detection and localization under arbitrary MRI modality availability. The framework integrates a dual-pathway DINOv2 encoder with a feature distribution alignment mechanism that statistically aligns incomplete-modality features with full-modality representations, enabling stable inference even with severe modality dropout. To further enhance semantic consistency, we introduce an Intrinsic Normal Prototypes (INPs) extractor and an INP-guided decoder that reconstruct only normal anatomical patterns while naturally amplifying abnormal deviations. Through randomized modality masking and indirect feature completion during training, the model learns to adapt to all modality configurations without re-training. Extensive experiments on BraTS2018, MU-Glioma-Post, and Pretreat-MetsToBrain-Masks demonstrate that our approach consistently surpasses state-of-the-art industrial and medical AD baselines across 7 modality combinations, achieving superior generalization. This study establishes a scalable paradigm for multimodal medical AD under real-world, imperfect modality conditions. Our source code is available at https://github.com/wuchangw/AnyAD.

Fan Bai, Yuxin Du, Tiejun Huang et al.

Medical image analysis is essential to clinical diagnosis and treatment, which is increasingly supported by multi-modal large language models (MLLMs). However, previous research has primarily focused on 2D medical images, leaving 3D images under-explored, despite their richer spatial information. This paper aims to advance 3D medical image analysis with MLLMs. To this end, we present a large-scale 3D multi-modal medical dataset, M3D-Data, comprising 120K image-text pairs and 662K instruction-response pairs specifically tailored for various 3D medical tasks, such as image-text retrieval, report generation, visual question answering, positioning, and segmentation. Additionally, we propose M3D-LaMed, a versatile multi-modal large language model for 3D medical image analysis. Furthermore, we introduce a new 3D multi-modal medical benchmark, M3D-Bench, which facilitates automatic evaluation across eight tasks. Through comprehensive evaluation, our method proves to be a robust model for 3D medical image analysis, outperforming existing solutions. All code, data, and models are publicly available at: https://github.com/BAAI-DCAI/M3D.

Pedro R. A. S. Bassi, Wenxuan Li, Yucheng Tang et al.

How can we test AI performance? This question seems trivial, but it isn't. Standard benchmarks often have problems such as in-distribution and small-size test sets, oversimplified metrics, unfair comparisons, and short-term outcome pressure. As a consequence, good performance on standard benchmarks does not guarantee success in real-world scenarios. To address these problems, we present Touchstone, a large-scale collaborative segmentation benchmark of 9 types of abdominal organs. This benchmark is based on 5,195 training CT scans from 76 hospitals around the world and 5,903 testing CT scans from 11 additional hospitals. This diverse test set enhances the statistical significance of benchmark results and rigorously evaluates AI algorithms across various out-of-distribution scenarios. We invited 14 inventors of 19 AI algorithms to train their algorithms, while our team, as a third party, independently evaluated these algorithms on three test sets. In addition, we also evaluated pre-existing AI frameworks--which, differing from algorithms, are more flexible and can support different algorithms--including MONAI from NVIDIA, nnU-Net from DKFZ, and numerous other open-source frameworks. We are committed to expanding this benchmark to encourage more innovation of AI algorithms for the medical domain.

Tao Lin, Yilei Zhong, Yuxin Du et al.

Vision-Language-Action (VLA) models have emerged as a powerful framework that unifies perception, language, and control, enabling robots to perform diverse tasks through multimodal understanding. However, current VLA models typically contain massive parameters and rely heavily on large-scale robot data pretraining, leading to high computational costs during training, as well as limited deployability for real-time inference. Moreover, most training paradigms often degrade the perceptual representations of the vision-language backbone, resulting in overfitting and poor generalization to downstream tasks. In this work, we present Evo-1, a lightweight VLA model that reduces computation and improves deployment efficiency, while maintaining strong performance without pretraining on robot data. Evo-1 builds on a native multimodal Vision-Language model (VLM), incorporating a novel cross-modulated diffusion transformer along with an optimized integration module, together forming an effective architecture. We further introduce a two-stage training paradigm that progressively aligns action with perception, preserving the representations of the VLM. Notably, with only 0.77 billion parameters, Evo-1 achieves state-of-the-art results on the Meta-World and RoboTwin suite, surpassing the previous best models by 12.4% and 6.9%, respectively, and also attains a competitive result of 94.8% on LIBERO. In real-world evaluations, Evo-1 attains a 78% success rate with high inference frequency and low memory overhead, outperforming all baseline methods. We release code, data, and model weights to facilitate future research on lightweight and efficient VLA models.

Tao Lin, Yuxin Du, Jiting Liu et al.

Vision-Language-Action models have emerged as a promising paradigm for robotic manipulation by unifying perception, language grounding, and action generation. However, they often struggle in scenarios requiring precise spatial understanding, as current VLA models primarily rely on 2D visual representations that lack depth information and detailed spatial relationships. While recent approaches incorporate explicit 3D inputs such as depth maps or point clouds to address this issue, they often increase system complexity, require additional sensors, and remain vulnerable to sensing noise and reconstruction errors. Another line of work explores implicit 3D-aware spatial modeling directly from RGB observations without extra sensors, but it often relies on large geometry foundation models, resulting in higher training and deployment costs. To address these challenges, we propose Evo-Depth, a lightweight depth-enhanced VLA framework that enhances spatially grounded manipulation without relying on additional sensing hardware or compromising deployment efficiency. Evo-Depth employs a lightweight Implicit Depth Encoding Module to extract compact depth features from multi-view RGB images. These features are incorporated into vision-language representations through a Spatial Enhancement Module via depth-aware modulation, enabling efficient spatial-semantic enhancement. A Progressive Alignment Training strategy is further introduced to align the resulting depth-enhanced representations with downstream action learning. With only 0.9B parameters, Evo-Depth achieves superior performance across four simulation benchmarks. In real-world experiments, Evo-Depth attains the highest average success rate while also exhibiting the smallest model size, lowest GPU memory usage, and highest inference frequency among compared methods.

Jiacheng Lu, Mingyuan Xiao, Weijian Wang et al.

The surge in micro-videos is transforming the concept of popularity. As researchers delve into vast multi-modal datasets, there is a growing interest in understanding the origins of this popularity and the forces driving its rapid expansion. Recent studies suggest that the virality of short videos is not only tied to their inherent multi-modal content but is also heavily influenced by the strength of platform recommendations driven by audience feedback. In this paper, we introduce a framework for capturing long-term dependencies in user feedback and dynamic event interactions, based on the Mamba Hawkes process. Our experiments on the large-scale open-source multi-modal dataset show that our model significantly outperforms state-of-the-art approaches across various metrics by 23.2%. We believe our model's capability to map the relationships within user feedback behavior sequences will not only contribute to the evolution of next-generation recommendation algorithms and platform applications but also enhance our understanding of micro video dissemination and its broader societal impact.

Yuxin Du, Tao Lin, Zile Zhong et al.

Monocular depth foundation models generalize well across scenes, yet they are typically optimized with uniform pixel-wise objectives that do not distinguish user-specified or task-relevant target regions from the surrounding context. We therefore introduce Focusable Monocular Depth Estimation (FDE), a region-aware depth estimation task in which, given a specified target region, the model is required to prioritize foreground depth accuracy, preserve sharp boundary transitions, and maintain coherent global scene geometry. To prioritize task-critical region modeling, we propose FocusDepth, a prompt-conditioned monocular relative depth estimation framework that guides depth modeling to focus on target regions via box/text prompts. The core Multi-Scale Spatial-Aligned Fusion (MSSA) in FocusDepth spatially aligns multi-scale features from Segment Anything Model 3 to the Depth Anything family and injects them through scale-specific, gated conditional fusion. This enables dense prompt cue injection without disrupting geometric representations, thereby endowing the depth estimation model with focused perception capability. To study FDE, we establish FDE-Bench, a target-centric monocular relative depth benchmark built from image-target-depth triplets across five datasets, containing 252.9K/72.5K train/val triplets and 972 categories spanning real-world and embodied simulation environments. On FDE-Bench, FocusDepth consistently improves over globally fine-tuned DA2/DA3 baselines under both box and text prompts, with the largest gains appearing in target boundary and foreground regions while preserving global scene geometry. Ablations show that MSSA's spatial alignment is the key design factor, as disrupting prompt-geometry correspondence increases AbsRel by up to 13.8%.

Changwei Wu, Yifei Chen, Yuxin Du et al.

Early diagnosis of Alzheimer's Disease (AD), especially at the mild cognitive impairment (MCI) stage, is vital yet hindered by subjective assessments and the high cost of multimodal imaging modalities. Although deep learning methods offer automated alternatives, their energy inefficiency and computational demands limit real-world deployment, particularly in resource-constrained settings. As a brain-inspired paradigm, spiking neural networks (SNNs) are inherently well-suited for modeling the sparse, event-driven patterns of neural degeneration in AD, offering a promising foundation for interpretable and low-power medical diagnostics. However, existing SNNs often suffer from weak expressiveness and unstable training, which restrict their effectiveness in complex medical tasks. To address these limitations, we propose FasterSNN, a hybrid neural architecture that integrates biologically inspired LIF neurons with region-adaptive convolution and multi-scale spiking attention. This design enables sparse, efficient processing of 3D MRI while preserving diagnostic accuracy. Experiments on benchmark datasets demonstrate that FasterSNN achieves competitive performance with substantially improved efficiency and stability, supporting its potential for practical AD screening. Our source code is available at https://github.com/wuchangw/FasterSNN.

Tao Lin, Gen Li, Yilei Zhong et al.

Vision-Language-Action (VLA) models have emerged as a promising framework for enabling generalist robots capable of perceiving, reasoning, and acting in the real world. These models usually build upon pretrained Vision-Language Models (VLMs), which excel at semantic understanding due to large-scale image and text pretraining. However, existing VLMs typically lack precise spatial understanding capabilities, as they are primarily tuned on 2D image-text pairs without 3D supervision. To address this limitation, recent approaches have incorporated explicit 3D inputs such as point clouds or depth maps, but this necessitates additional depth sensors or pre-trained depth estimation models, which may yield defective results. In contrast, our work introduces a plug-and-play module that implicitly incorporates 3D geometry features into VLA models by leveraging an off-the-shelf visual geometry foundation model. This integration provides the model with depth-aware visual representations, improving its ability to understand the geometric structure of the scene and the spatial relationships among objects from RGB images alone. We evaluate our method on a set of spatially challenging tasks in both simulation and the real world. Extensive evaluations show that our method significantly improves the performance of state-of-the-art VLA models across diverse scenarios.