Jiahan Li

Zhiqi Li, Zhiding Yu, Shiyi Lan et al.

End-to-end autonomous driving recently emerged as a promising research direction to target autonomy from a full-stack perspective. Along this line, many of the latest works follow an open-loop evaluation setting on nuScenes to study the planning behavior. In this paper, we delve deeper into the problem by conducting thorough analyses and demystifying more devils in the details. We initially observed that the nuScenes dataset, characterized by relatively simple driving scenarios, leads to an under-utilization of perception information in end-to-end models incorporating ego status, such as the ego vehicle's velocity. These models tend to rely predominantly on the ego vehicle's status for future path planning. Beyond the limitations of the dataset, we also note that current metrics do not comprehensively assess the planning quality, leading to potentially biased conclusions drawn from existing benchmarks. To address this issue, we introduce a new metric to evaluate whether the predicted trajectories adhere to the road. We further propose a simple baseline able to achieve competitive results without relying on perception annotations. Given the current limitations on the benchmark and metrics, we suggest the community reassess relevant prevailing research and be cautious whether the continued pursuit of state-of-the-art would yield convincing and universal conclusions. Code and models are available at \url{https://github.com/NVlabs/BEV-Planner}

Xiangxin Zhou, Mingyu Li, Yi Xiao et al.

Cyclic peptides offer inherent advantages in pharmaceuticals. For example, cyclic peptides are more resistant to enzymatic hydrolysis compared to linear peptides and usually exhibit excellent stability and affinity. Although deep generative models have achieved great success in linear peptide design, several challenges prevent the development of computational methods for designing diverse types of cyclic peptides. These challenges include the scarcity of 3D structural data on target proteins and associated cyclic peptide ligands, the geometric constraints that cyclization imposes, and the involvement of non-canonical amino acids in cyclization. To address the above challenges, we introduce CpSDE, which consists of two key components: AtomSDE, a generative structure prediction model based on harmonic SDE, and ResRouter, a residue type predictor. Utilizing a routed sampling algorithm that alternates between these two models to iteratively update sequences and structures, CpSDE facilitates the generation of cyclic peptides. By employing explicit all-atom and bond modeling, CpSDE overcomes existing data limitations and is proficient in designing a wide variety of cyclic peptides. Our experimental results demonstrate that the cyclic peptides designed by our method exhibit reliable stability and affinity.