Chenxin Li

Chenxin Li, Mingbao Lin, Zhiyuan Ding et al.

Knowledge Distillation (KD) transfers the knowledge from a high-capacity teacher network to strengthen a smaller student. Existing methods focus on excavating the knowledge hints and transferring the whole knowledge to the student. However, the knowledge redundancy arises since the knowledge shows different values to the student at different learning stages. In this paper, we propose Knowledge Condensation Distillation (KCD). Specifically, the knowledge value on each sample is dynamically estimated, based on which an Expectation-Maximization (EM) framework is forged to iteratively condense a compact knowledge set from the teacher to guide the student learning. Our approach is easy to build on top of the off-the-shelf KD methods, with no extra training parameters and negligible computation overhead. Thus, it presents one new perspective for KD, in which the student that actively identifies teacher's knowledge in line with its aptitude can learn to learn more effectively and efficiently. Experiments on standard benchmarks manifest that the proposed KCD can well boost the performance of student model with even higher distillation efficiency. Code is available at https://github.com/dzy3/KCD.

Zhenye Lou, Qing Xu, Zekun Jiang et al.

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the Segment Anything Model (SAM) has made great success in universal image segmentation by interactive prompt modes (e.g., point and box). Despite its strengths, the original SAM presents limited adaptation to medical images. Moreover, SAM requires providing manual bounding box prompts for each object to produce satisfactory segmentation masks, so it is laborious in nuclei segmentation scenarios. To address these limitations, we propose a domain-generalizable framework for nuclei image segmentation, abbreviated to NuSegDG. Specifically, we first devise a Heterogeneous Space Adapter (HS-Adapter) to learn multi-dimensional feature representations of different nuclei domains by injecting a small number of trainable parameters into the image encoder of SAM. To alleviate the labor-intensive requirement of manual prompts, we introduce a Gaussian-Kernel Prompt Encoder (GKP-Encoder) to generate density maps driven by a single point, which guides segmentation predictions by mixing position prompts and semantic prompts. Furthermore, we present a Two-Stage Mask Decoder (TSM-Decoder) to effectively convert semantic masks to instance maps without the manual demand for morphological shape refinement. Based on our experimental evaluations, the proposed NuSegDG demonstrates state-of-the-art performance in nuclei instance segmentation, exhibiting superior domain generalization capabilities. The source code is available at https://github.com/xq141839/NuSegDG.

Qing Xu, Jiaxuan Li, Xiangjian He et al.

The universality of deep neural networks across different modalities and their generalization capabilities to unseen domains play an essential role in medical image segmentation. The recent segment anything model (SAM) has demonstrated strong adaptability across diverse natural scenarios. However, the huge computational costs, demand for manual annotations as prompts and conflict-prone decoding process of SAM degrade its generalization capabilities in medical scenarios. To address these limitations, we propose a modality-decoupled lightweight SAM for domain-generalized medical image segmentation, named De-LightSAM. Specifically, we first devise a lightweight domain-controllable image encoder (DC-Encoder) that produces discriminative visual features for diverse modalities. Further, we introduce the self-patch prompt generator (SP-Generator) to automatically generate high-quality dense prompt embeddings for guiding segmentation decoding. Finally, we design the query-decoupled modality decoder (QM-Decoder) that leverages a one-to-one strategy to provide an independent decoding channel for every modality, preventing mutual knowledge interference of different modalities. Moreover, we design a multi-modal decoupled knowledge distillation (MDKD) strategy to leverage robust common knowledge to complement domain-specific medical feature representations. Extensive experiments indicate that De-LightSAM outperforms state-of-the-arts in diverse medical imaging segmentation tasks, displaying superior modality universality and generalization capabilities. Especially, De-LightSAM uses only 2.0% parameters compared to SAM-H. The source code is available at https://github.com/xq141839/De-LightSAM.

Zhengyang Tang, Ke Ji, Xidong Wang et al.

We study whether phone-use agents respect privacy while completing benign mobile tasks. This question has remained hard to answer because privacy-compliant behavior is not operationalized for phone-use agents, and ordinary apps do not reveal exactly what data agents type into which form entries during execution. To make this question measurable, we introduce MyPhoneBench, a verifiable evaluation framework for privacy behavior in mobile agents. We operationalize privacy-respecting phone use as permissioned access, minimal disclosure, and user-controlled memory through a minimal privacy contract, iMy, and pair it with instrumented mock apps plus rule-based auditing that make unnecessary permission requests, deceptive re-disclosure, and unnecessary form filling observable and reproducible. Across five frontier models on 10 mobile apps and 300 tasks, we find that task success, privacy-compliant task completion, and later-session use of saved preferences are distinct capabilities, and no single model dominates all three. Evaluating success and privacy jointly reshuffles the model ordering relative to either metric alone. The most persistent failure mode across models is simple data minimization: agents still fill optional personal entries that the task does not require. These results show that privacy failures arise from over-helpful execution of benign tasks, and that success-only evaluation overestimates the deployment readiness of current phone-use agents. All code, mock apps, and agent trajectories are publicly available at~ https://github.com/tangzhy/MyPhoneBench.

Haote Xu, Yunlong Zhang, Liyan Sun et al.

Anomaly Detection (AD) on medical images enables a model to recognize any type of anomaly pattern without lesion-specific supervised learning. Data augmentation based methods construct pseudo-healthy images by "pasting" fake lesions on real healthy ones, and a network is trained to predict healthy images in a supervised manner. The lesion can be found by difference between the unhealthy input and pseudo-healthy output. However, using only manually designed fake lesions fail to approximate to irregular real lesions, hence limiting the model generalization. We assume by exploring the intrinsic data property within images, we can distinguish previously unseen lesions from healthy regions in an unhealthy image. In this study, we propose an Adaptive Fourier Space Compression (AFSC) module to distill healthy feature for AD. The compression of both magnitude and phase in frequency domain addresses the hyper intensity and diverse position of lesions. Experimental results on the BraTS and MS-SEG datasets demonstrate an AFSC baseline is able to produce promising detection results, and an AFSC module can be effectively embedded into existing AD methods.

Chenxin Li, Brandon Y. Feng, Zhiwen Fan et al.

Recent advances in neural rendering imply a future of widespread visual data distributions through sharing NeRF model weights. However, while common visual data (images and videos) have standard approaches to embed ownership or copyright information explicitly or subtly, the problem remains unexplored for the emerging NeRF format. We present StegaNeRF, a method for steganographic information embedding in NeRF renderings. We design an optimization framework allowing accurate hidden information extractions from images rendered by NeRF, while preserving its original visual quality. We perform experimental evaluations of our method under several potential deployment scenarios, and we further discuss the insights discovered through our analysis. StegaNeRF signifies an initial exploration into the novel problem of instilling customizable, imperceptible, and recoverable information to NeRF renderings, with minimal impact to rendered images. Project page: https://xggnet.github.io/StegaNeRF/.

Ming Li, Jike Zhong, Chenxin Li et al.

Recent advances in fine-tuning Vision-Language Models (VLMs) have witnessed the success of prompt tuning and adapter tuning, while the classic model fine-tuning on inherent parameters seems to be overlooked. It is believed that fine-tuning the parameters of VLMs with few-shot samples corrupts the pre-trained knowledge since fine-tuning the CLIP model even degrades performance. In this paper, we revisit this viewpoint, and propose a new perspective: fine-tuning the specific parameters instead of all will uncover the power of classic model fine-tuning on VLMs. Through our meticulous study, we propose ClipFit, a simple yet effective method to fine-tune CLIP without introducing any overhead of extra parameters. We demonstrate that by only fine-tuning the specific bias terms and normalization layers, ClipFit can improve the performance of zero-shot CLIP by 7.27\% average harmonic mean accuracy. Lastly, to understand how fine-tuning in CLIPFit affects the pre-trained models, we conducted extensive experimental analyses w.r.t. changes in internal parameters and representations. We found that low-level text bias layers and the first layer normalization layer change much more than other layers. The code is available at \url{https://github.com/minglllli/CLIPFit}.

Panwang Pan, Zhiwen Fan, Brandon Y. Feng et al.

The accurate estimation of six degrees-of-freedom (6DoF) object poses is essential for many applications in robotics and augmented reality. However, existing methods for 6DoF pose estimation often depend on CAD templates or dense support views, restricting their usefulness in realworld situations. In this study, we present a new cascade framework named Cas6D for few-shot 6DoF pose estimation that is generalizable and uses only RGB images. To address the false positives of target object detection in the extreme few-shot setting, our framework utilizes a selfsupervised pre-trained ViT to learn robust feature representations. Then, we initialize the nearest top-K pose candidates based on similarity score and refine the initial poses using feature pyramids to formulate and update the cascade warped feature volume, which encodes context at increasingly finer scales. By discretizing the pose search range using multiple pose bins and progressively narrowing the pose search range in each stage using predictions from the previous stage, Cas6D can overcome the large gap between pose candidates and ground truth poses, which is a common failure mode in sparse-view scenarios. Experimental results on the LINEMOD and GenMOP datasets demonstrate that Cas6D outperforms state-of-the-art methods by 9.2% and 3.8% accuracy (Proj-5) under the 32-shot setting compared to OnePose++ and Gen6D.

Shengyuan Liu, Liuxin Bao, Qi Yang et al.

Medical image segmentation is evolving from task-specific models toward generalizable frameworks. Recent research leverages Multi-modal Large Language Models (MLLMs) as autonomous agents, employing reinforcement learning with verifiable reward (RLVR) to orchestrate specialized tools like the Segment Anything Model (SAM). However, these approaches often rely on single-turn, rigid interaction strategies and lack process-level supervision during training, which hinders their ability to fully exploit the dynamic potential of interactive tools and leads to redundant actions. To bridge this gap, we propose MedSAM-Agent, a framework that reformulates interactive segmentation as a multi-step autonomous decision-making process. First, we introduce a hybrid prompting strategy for expert-curated trajectory generation, enabling the model to internalize human-like decision heuristics and adaptive refinement strategies. Furthermore, we develop a two-stage training pipeline that integrates multi-turn, end-to-end outcome verification with a clinical-fidelity process reward design to promote interaction parsimony and decision efficiency. Extensive experiments across 6 medical modalities and 21 datasets demonstrate that MedSAM-Agent achieves state-of-the-art performance, effectively unifying autonomous medical reasoning with robust, iterative optimization. Code is available \href{https://github.com/CUHK-AIM-Group/MedSAM-Agent}{here}.

Yiyang Liu, Chenxin Li, Xiaotong Tu et al.

Knowledge Distillation (KD) transfers the knowledge from a high-capacity teacher model to promote a smaller student model. Existing efforts guide the distillation by matching their prediction logits, feature embedding, etc., while leaving how to efficiently utilize them in junction less explored. In this paper, we propose Hint-dynamic Knowledge Distillation, dubbed HKD, which excavates the knowledge from the teacher' s hints in a dynamic scheme. The guidance effect from the knowledge hints usually varies in different instances and learning stages, which motivates us to customize a specific hint-learning manner for each instance adaptively. Specifically, a meta-weight network is introduced to generate the instance-wise weight coefficients about knowledge hints in the perception of the dynamical learning progress of the student model. We further present a weight ensembling strategy to eliminate the potential bias of coefficient estimation by exploiting the historical statics. Experiments on standard benchmarks of CIFAR-100 and Tiny-ImageNet manifest that the proposed HKD well boost the effect of knowledge distillation tasks.

Chenxin Li, Xinyu Liu, Cheng Wang et al.

Recent advances in learning multi-modal representation have witnessed the success in biomedical domains. While established techniques enable handling multi-modal information, the challenges are posed when extended to various clinical modalities and practical modalitymissing setting due to the inherent modality gaps. To tackle these, we propose an innovative Modality-prompted Heterogeneous Graph for Omnimodal Learning (GTP-4o), which embeds the numerous disparate clinical modalities into a unified representation, completes the deficient embedding of missing modality and reformulates the cross-modal learning with a graph-based aggregation. Specially, we establish a heterogeneous graph embedding to explicitly capture the diverse semantic properties on both the modality-specific features (nodes) and the cross-modal relations (edges). Then, we design a modality-prompted completion that enables completing the inadequate graph representation of missing modality through a graph prompting mechanism, which generates hallucination graphic topologies to steer the missing embedding towards the intact representation. Through the completed graph, we meticulously develop a knowledge-guided hierarchical cross-modal aggregation consisting of a global meta-path neighbouring to uncover the potential heterogeneous neighbors along the pathways driven by domain knowledge, and a local multi-relation aggregation module for the comprehensive cross-modal interaction across various heterogeneous relations. We assess the efficacy of our methodology on rigorous benchmarking experiments against prior state-of-the-arts. In a nutshell, GTP-4o presents an initial foray into the intriguing realm of embedding, relating and perceiving the heterogeneous patterns from various clinical modalities holistically via a graph theory. Project page: https://gtp-4-o.github.io/.

Chenxin Li, Hengyu Liu, Zhiwen Fan et al.

Recent advancements in large generative models and real-time neural rendering using point-based techniques pave the way for a future of widespread visual data distribution through sharing synthesized 3D assets. However, while standardized methods for embedding proprietary or copyright information, either overtly or subtly, exist for conventional visual content such as images and videos, this issue remains unexplored for emerging generative 3D formats like Gaussian Splatting. We present GaussianStego, a method for embedding steganographic information in the rendering of generated 3D assets. Our approach employs an optimization framework that enables the accurate extraction of hidden information from images rendered using Gaussian assets derived from large models, while maintaining their original visual quality. We conduct preliminary evaluations of our method across several potential deployment scenarios and discuss issues identified through analysis. GaussianStego represents an initial exploration into the novel challenge of embedding customizable, imperceptible, and recoverable information within the renders produced by current 3D generative models, while ensuring minimal impact on the rendered content's quality.

Chenxin Li, Brandon Y. Feng, Yifan Liu et al.

3D reconstruction of biological tissues from a collection of endoscopic images is a key to unlock various important downstream surgical applications with 3D capabilities. Existing methods employ various advanced neural rendering techniques for photorealistic view synthesis, but they often struggle to recover accurate 3D representations when only sparse observations are available, which is usually the case in real-world clinical scenarios. To tackle this {sparsity} challenge, we propose a framework leveraging the prior knowledge from multiple foundation models during the reconstruction process, dubbed as \textit{EndoSparse}. Experimental results indicate that our proposed strategy significantly improves the geometric and appearance quality under challenging sparse-view conditions, including using only three views. In rigorous benchmarking experiments against state-of-the-art methods, \textit{EndoSparse} achieves superior results in terms of accurate geometry, realistic appearance, and rendering efficiency, confirming the robustness to sparse-view limitations in endoscopic reconstruction. \textit{EndoSparse} signifies a steady step towards the practical deployment of neural 3D reconstruction in real-world clinical scenarios. Project page: https://endo-sparse.github.io/.

Zhijie Rao, Jingcai Guo, Xiaocheng Lu et al.

Generalized Zero-shot Learning (GZSL) has yielded remarkable performance by designing a series of unbiased visual-semantics mappings, wherein, the precision relies heavily on the completeness of extracted visual features from both seen and unseen classes. However, as a common practice in GZSL, the pre-trained feature extractor may easily exhibit difficulty in capturing domain-specific traits of the downstream tasks/datasets to provide fine-grained discriminative features, i.e., domain bias, which hinders the overall recognition performance, especially for unseen classes. Recent studies partially address this issue by fine-tuning feature extractors, while may inevitably incur catastrophic forgetting and overfitting issues. In this paper, we propose a simple yet effective Attribute-Aware Representation Rectification framework for GZSL, dubbed $\mathbf{(AR)^{2}}$, to adaptively rectify the feature extractor to learn novel features while keeping original valuable features. Specifically, our method consists of two key components, i.e., Unseen-Aware Distillation (UAD) and Attribute-Guided Learning (AGL). During training, UAD exploits the prior knowledge of attribute texts that are shared by both seen/unseen classes with attention mechanisms to detect and maintain unseen class-sensitive visual features in a targeted manner, and meanwhile, AGL aims to steer the model to focus on valuable features and suppress them to fit noisy elements in the seen classes by attribute-guided representation learning. Extensive experiments on various benchmark datasets demonstrate the effectiveness of our method.

Lap Yan Lennon Chan, Chenxin Li, Yixuan Yuan

Accurate lesion segmentation in whole-body PET/CT scans is crucial for cancer diagnosis and treatment planning, but limited datasets often hinder the performance of automated segmentation models. In this paper, we explore the potential of leveraging the deep prior from a generative model to serve as a data augmenter for automated lesion segmentation in PET/CT scans. We adapt the DiffTumor method, originally designed for CT images, to generate synthetic PET-CT images with lesions. Our approach trains the generative model on the AutoPET dataset and uses it to expand the training data. We then compare the performance of segmentation models trained on the original and augmented datasets. Our findings show that the model trained on the augmented dataset achieves a higher Dice score, demonstrating the potential of our data augmentation approach. In a nutshell, this work presents a promising direction for improving lesion segmentation in whole-body PET/CT scans with limited datasets, potentially enhancing the accuracy and reliability of cancer diagnostics.

Yifan Liu, Chenxin Li, Chen Yang et al.

Reconstructing deformable tissues from endoscopic videos is essential in many downstream surgical applications. However, existing methods suffer from slow rendering speed, greatly limiting their practical use. In this paper, we introduce EndoGaussian, a real-time endoscopic scene reconstruction framework built on 3D Gaussian Splatting (3DGS). By integrating the efficient Gaussian representation and highly-optimized rendering engine, our framework significantly boosts the rendering speed to a real-time level. To adapt 3DGS for endoscopic scenes, we propose two strategies, Holistic Gaussian Initialization (HGI) and Spatio-temporal Gaussian Tracking (SGT), to handle the non-trivial Gaussian initialization and tissue deformation problems, respectively. In HGI, we leverage recent depth estimation models to predict depth maps of input binocular/monocular image sequences, based on which pixels are re-projected and combined for holistic initialization. In SPT, we propose to model surface dynamics using a deformation field, which is composed of an efficient encoding voxel and a lightweight deformation decoder, allowing for Gaussian tracking with minor training and rendering burden. Experiments on public datasets demonstrate our efficacy against prior SOTAs in many aspects, including better rendering speed (195 FPS real-time, 100$\times$ gain), better rendering quality (37.848 PSNR), and less training overhead (within 2 min/scene), showing significant promise for intraoperative surgery applications. Code is available at: \url{https://yifliu3.github.io/EndoGaussian/}.

Liye Chen, Biaoshun Li, Yihao Chen et al.

Antibody-drug conjugate (ADC) has revolutionized the field of cancer treatment in the era of precision medicine due to their ability to precisely target cancer cells and release highly effective drug. Nevertheless, the realization of rational design of ADC is very difficult because the relationship between their structures and activities is difficult to understand. In the present study, we introduce a unified deep learning framework called ADCNet to help design potential ADCs. The ADCNet highly integrates the protein representation learning language model ESM-2 and small-molecule representation learning language model FG-BERT models to achieve activity prediction through learning meaningful features from antigen and antibody protein sequences of ADC, SMILES strings of linker and payload, and drug-antibody ratio (DAR) value. Based on a carefully designed and manually tailored ADC data set, extensive evaluation results reveal that ADCNet performs best on the test set compared to baseline machine learning models across all evaluation metrics. For example, it achieves an average prediction accuracy of 87.12%, a balanced accuracy of 0.8689, and an area under receiver operating characteristic curve of 0.9293 on the test set. In addition, cross-validation, ablation experiments, and external independent testing results further prove the stability, advancement, and robustness of the ADCNet architecture. For the convenience of the community, we develop the first online platform (https://ADCNet.idruglab.cn) for the prediction of ADCs activity based on the optimal ADCNet model, and the source code is publicly available at https://github.com/idrugLab/ADCNet.

Panwang Pan, Jingjing Zhao, Yuchen Lin et al.

Video generative models pretrained on large-scale datasets can produce high-quality videos, but are often conditioned on text or a single image, limiting controllability and applicability. We introduce ID-Composer, a novel framework that addresses this gap by tackling multi-subject video generation from a text prompt and reference images. This task is challenging as it requires preserving subject identities, integrating semantics across subjects and modalities, and maintaining temporal consistency. To faithfully preserve the subject consistency and textual information in synthesized videos, ID-Composer designs a hierarchical identity-preserving attention mechanism, which effectively aggregates features within and across subjects and modalities. To effectively allow for the semantic following of user intention, we introduce semantic understanding via pretrained vision-language model (VLM), leveraging VLM's superior semantic understanding to provide fine-grained guidance and capture complex interactions between multiple subjects. Considering that standard diffusion loss often fails in aligning the critical concepts like subject ID, we employ an online reinforcement learning phase to drive the overall training objective of ID-Composer into RLVR. Extensive experiments demonstrate that our model surpasses existing methods in identity preservation, temporal consistency, and video quality.

Panwang Pan, Chenguo Lin, Jingjing Zhao et al.

We introduce Diff4Splat, a feed-forward method that synthesizes controllable and explicit 4D scenes from a single image. Our approach unifies the generative priors of video diffusion models with geometry and motion constraints learned from large-scale 4D datasets. Given a single input image, a camera trajectory, and an optional text prompt, Diff4Splat directly predicts a deformable 3D Gaussian field that encodes appearance, geometry, and motion, all in a single forward pass, without test-time optimization or post-hoc refinement. At the core of our framework lies a video latent transformer, which augments video diffusion models to jointly capture spatio-temporal dependencies and predict time-varying 3D Gaussian primitives. Training is guided by objectives on appearance fidelity, geometric accuracy, and motion consistency, enabling Diff4Splat to synthesize high-quality 4D scenes in 30 seconds. We demonstrate the effectiveness of Diff4Splatacross video generation, novel view synthesis, and geometry extraction, where it matches or surpasses optimization-based methods for dynamic scene synthesis while being significantly more efficient.

Yifan Liu, Wuyang Li, Weihao Yu et al.

Computed Tomography serves as an indispensable tool in clinical workflows, providing non-invasive visualization of internal anatomical structures. Existing CT reconstruction works are limited to small-capacity model architecture and inflexible volume representation. In this work, we present X-GRM (X-ray Gaussian Reconstruction Model), a large feedforward model for reconstructing 3D CT volumes from sparse-view 2D X-ray projections. X-GRM employs a scalable transformer-based architecture to encode sparse-view X-ray inputs, where tokens from different views are integrated efficiently. Then, these tokens are decoded into a novel volume representation, named Voxel-based Gaussian Splatting (VoxGS), which enables efficient CT volume extraction and differentiable X-ray rendering. This combination of a high-capacity model and flexible volume representation, empowers our model to produce high-quality reconstructions from various testing inputs, including in-domain and out-domain X-ray projections. Our codes are available at: https://github.com/CUHK-AIM-Group/X-GRM.

Qing Xu, Zhenye Lou, Chenxin Li et al.

High-resolution segmentation is critical for precise disease diagnosis by extracting fine-grained morphological details. Existing hierarchical encoder-decoder frameworks have demonstrated remarkable adaptability across diverse medical segmentation tasks. While beneficial, they usually require the huge computation and memory cost when handling large-size segmentation, which limits their applications in foundation model building and real-world clinical scenarios. To address this limitation, we propose a holistically efficient framework for high-resolution medical image segmentation, called HER-Seg. Specifically, we first devise a computation-efficient image encoder (CE-Encoder) to model long-range dependencies with linear complexity while maintaining sufficient representations. In particular, we introduce the dual-gated linear attention (DLA) mechanism to perform cascaded token filtering, selectively retaining important tokens while ignoring irrelevant ones to enhance attention computation efficiency. Then, we introduce a memory-efficient mask decoder (ME-Decoder) to eliminate the demand for the hierarchical structure by leveraging cross-scale segmentation decoding. Extensive experiments reveal that HER-Seg outperforms state-of-the-arts in high-resolution medical 2D, 3D and video segmentation tasks. In particular, our HER-Seg requires only 0.59GB training GPU memory and 9.39G inference FLOPs per 1024$\times$1024 image, demonstrating superior memory and computation efficiency. The code is available at https://github.com/xq141839/HER-Seg.

Chenxin Li, Hengyu Liu, Yifan Liu et al.

Generative models hold promise for revolutionizing medical education, robot-assisted surgery, and data augmentation for machine learning. Despite progress in generating 2D medical images, the complex domain of clinical video generation has largely remained untapped.This paper introduces \model, an innovative approach to generate medical videos that simulate clinical endoscopy scenes. We present a novel generative model design that integrates a meticulously crafted spatial-temporal video transformer with advanced 2D vision foundation model priors, explicitly modeling spatial-temporal dynamics during video generation. We also pioneer the first public benchmark for endoscopy simulation with video generation models, adapting existing state-of-the-art methods for this endeavor.Endora demonstrates exceptional visual quality in generating endoscopy videos, surpassing state-of-the-art methods in extensive testing. Moreover, we explore how this endoscopy simulator can empower downstream video analysis tasks and even generate 3D medical scenes with multi-view consistency. In a nutshell, Endora marks a notable breakthrough in the deployment of generative AI for clinical endoscopy research, setting a substantial stage for further advances in medical content generation. For more details, please visit our project page: https://endora-medvidgen.github.io/.

Parker Liu, Chenxin Li, Zhengxin Li et al.

Vision-language models (VLMs) excel at descriptive tasks, but whether they truly understand scenes from visual observations remains uncertain. We introduce IR3D-Bench, a benchmark challenging VLMs to demonstrate understanding through active creation rather than passive recognition. Grounded in the analysis-by-synthesis paradigm, IR3D-Bench tasks Vision-Language Agents (VLAs) with actively using programming and rendering tools to recreate the underlying 3D structure of an input image, achieving agentic inverse rendering through tool use. This "understanding-by-creating" approach probes the tool-using generative capacity of VLAs, moving beyond the descriptive or conversational capacity measured by traditional scene understanding benchmarks. We provide a comprehensive suite of metrics to evaluate geometric accuracy, spatial relations, appearance attributes, and overall plausibility. Initial experiments on agentic inverse rendering powered by various state-of-the-art VLMs highlight current limitations, particularly in visual precision rather than basic tool usage. IR3D-Bench, including data and evaluation protocols, is released to facilitate systematic study and development of tool-using VLAs towards genuine scene understanding by creating.

Zhongnan Cai, Yingying Wang, Yunlong Lin et al.

Recently, deep learning-based pan-sharpening algorithms have achieved notable advancements over traditional methods. However, many deep learning-based approaches incur substantial computational overhead during inference, especially with high-resolution images. This excessive computational demand limits the applicability of these methods in real-world scenarios, particularly in the absence of dedicated computing devices such as GPUs and TPUs. To address these challenges, we propose Pan-LUT, a novel learnable look-up table (LUT) framework for pan-sharpening that strikes a balance between performance and computational efficiency for high-resolution remote sensing images. To finely control the spectral transformation, we devise the PAN-guided look-up table (PGLUT) for channel-wise spectral mapping. To effectively capture fine-grained spatial details and adaptively learn local contexts, we introduce the spatial details look-up table (SDLUT) and adaptive aggregation look-up table (AALUT). Our proposed method contains fewer than 300K parameters and processes a 8K resolution image in under 1 ms using a single NVIDIA GeForce RTX 2080 Ti GPU, demonstrating significantly faster performance compared to other methods. Experiments reveal that Pan-LUT efficiently processes large remote sensing images in a lightweight manner, bridging the gap to real-world applications. Furthermore, our model surpasses SOTA methods in full-resolution scenes under real-world conditions, highlighting its effectiveness and efficiency.

Hengyu Liu, Yifan Liu, Chenxin Li et al.

The advent of 3D Gaussian Splatting (3D-GS) techniques and their dynamic scene modeling variants, 4D-GS, offers promising prospects for real-time rendering of dynamic surgical scenarios. However, the prerequisite for modeling dynamic scenes by a large number of Gaussian units, the high-dimensional Gaussian attributes and the high-resolution deformation fields, all lead to serve storage issues that hinder real-time rendering in resource-limited surgical equipment. To surmount these limitations, we introduce a Lightweight 4D Gaussian Splatting framework (LGS) that can liberate the efficiency bottlenecks of both rendering and storage for dynamic endoscopic reconstruction. Specifically, to minimize the redundancy of Gaussian quantities, we propose Deformation-Aware Pruning by gauging the impact of each Gaussian on deformation. Concurrently, to reduce the redundancy of Gaussian attributes, we simplify the representation of textures and lighting in non-crucial areas by pruning the dimensions of Gaussian attributes. We further resolve the feature field redundancy caused by the high resolution of 4D neural spatiotemporal encoder for modeling dynamic scenes via a 4D feature field condensation. Experiments on public benchmarks demonstrate efficacy of LGS in terms of a compression rate exceeding 9 times while maintaining the pleasing visual quality and real-time rendering efficiency. LGS confirms a substantial step towards its application in robotic surgical services.

Chenxin Li, Xinyu Liu, Wuyang Li et al.

U-Net has become a cornerstone in various visual applications such as image segmentation and diffusion probability models. While numerous innovative designs and improvements have been introduced by incorporating transformers or MLPs, the networks are still limited to linearly modeling patterns as well as the deficient interpretability. To address these challenges, our intuition is inspired by the impressive results of the Kolmogorov-Arnold Networks (KANs) in terms of accuracy and interpretability, which reshape the neural network learning via the stack of non-linear learnable activation functions derived from the Kolmogorov-Anold representation theorem. Specifically, in this paper, we explore the untapped potential of KANs in improving backbones for vision tasks. We investigate, modify and re-design the established U-Net pipeline by integrating the dedicated KAN layers on the tokenized intermediate representation, termed U-KAN. Rigorous medical image segmentation benchmarks verify the superiority of U-KAN by higher accuracy even with less computation cost. We further delved into the potential of U-KAN as an alternative U-Net noise predictor in diffusion models, demonstrating its applicability in generating task-oriented model architectures. These endeavours unveil valuable insights and sheds light on the prospect that with U-KAN, you can make strong backbone for medical image segmentation and generation. Project page:\url{https://yes-u-kan.github.io/}.

Chenxin Li, Qi Qi, Xinghao Ding et al.

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which aims to learn a model from multiple source domains such that it can be directly generalized to unseen test domains, seems particularly promising to medical imaging community. To address DG, recent model-agnostic meta-learning (MAML) has been introduced, which transfers the knowledge from previous training tasks to facilitate the learning of novel testing tasks. However, in clinical practice, there are usually only a few annotated source domains available, which decreases the capacity of training task generation and thus increases the risk of overfitting to training tasks in the paradigm. In this paper, we propose a novel DG scheme of episodic training with task augmentation on medical imaging classification. Based on meta-learning, we develop the paradigm of episodic training to construct the knowledge transfer from episodic training-task simulation to the real testing task of DG. Motivated by the limited number of source domains in real-world medical deployment, we consider the unique task-level overfitting and we propose task augmentation to enhance the variety during training task generation to alleviate it. With the established learning framework, we further exploit a novel meta-objective to regularize the deep embedding of training domains. To validate the effectiveness of the proposed method, we perform experiments on histopathological images and abdominal CT images.

Chenxin Li, Wenao Ma, Liyan Sun et al.

The analysis of organ vessels is essential for computer-aided diagnosis and surgical planning. But it is not a easy task since the fine-detailed connected regions of organ vessel bring a lot of ambiguity in vessel segmentation and sub-type recognition, especially for the low-contrast capillary regions. Furthermore, recent two-staged approaches would accumulate and even amplify these inaccuracies from the first-stage whole vessel segmentation into the second-stage sub-type vessel pixel-wise classification. Moreover, the scarcity of manual annotation in organ vessels poses another challenge. In this paper, to address the above issues, we propose a hierarchical deep network where an attention mechanism localizes the low-contrast capillary regions guided by the whole vessels, and enhance the spatial activation in those areas for the sub-type vessels. In addition, we propose an uncertainty-aware semi-supervised training framework to alleviate the annotation-hungry limitation of deep models. The proposed method achieves the state-of-the-art performance in the benchmarks of both retinal artery/vein segmentation in fundus images and liver portal/hepatic vessel segmentation in CT images.

Chenxin Li, Yunlong Zhang, Zhehan Liang et al.

Retinal artery/vein (A/V) classification is a critical technique for diagnosing diabetes and cardiovascular diseases. Although deep learning based methods achieve impressive results in A/V classification, their performances usually degrade severely when being directly applied to another database, due to the domain shift, e.g., caused by the variations in imaging protocols. In this paper, we propose a novel vessel-mixing based consistency regularization framework, for cross-domain learning in retinal A/V classification. Specially, to alleviate the severe bias to source domain, based on the label smooth prior, the model is regularized to give consistent predictions for unlabeled target-domain inputs that are under perturbation. This consistency regularization implicitly introduces a mechanism where the model and the perturbation is opponent to each other, where the model is pushed to be robust enough to cope with the perturbation. Thus, we investigate a more difficult opponent to further inspire the robustness of model, in the scenario of retinal A/V, called vessel-mixing perturbation. Specially, it effectively disturbs the fundus images especially the vessel structures by mixing two images regionally. We conduct extensive experiments on cross-domain A/V classification using four public datasets, which are collected by diverse institutions and imaging devices. The results demonstrate that our method achieves the state-of-the-art cross-domain performance, which is also close to the upper bound obtained by fully supervised learning on target domain.

Chenxin Li, Yunlong Zhang, Jiongcheng Li et al.

The goal of unsupervised anomaly segmentation (UAS) is to detect the pixel-level anomalies unseen during training. It is a promising field in the medical imaging community, e.g, we can use the model trained with only healthy data to segment the lesions of rare diseases. Existing methods are mainly based on Information Bottleneck, whose underlying principle is modeling the distribution of normal anatomy via learning to compress and recover the healthy data with a low-dimensional manifold, and then detecting lesions as the outlier from this learned distribution. However, this dimensionality reduction inevitably damages the localization information, which is especially essential for pixel-level anomaly detection. In this paper, to alleviate this issue, we introduce the semantic space of healthy anatomy in the process of modeling healthy-data distribution. More precisely, we view the couple of segmentation and synthesis as a special Autoencoder, and propose a novel cycle translation framework with a journey of 'image->semantic->image'. Experimental results on the BraTS and ISLES databases show that the proposed approach achieves significantly superior performance compared to several prior methods and segments the anomalies more accurately.

Liyan Sun, Chenxin Li, Xinghao Ding et al.

Despite deep convolutional neural networks achieved impressive progress in medical image computing and analysis, its paradigm of supervised learning demands a large number of annotations for training to avoid overfitting and achieving promising results. In clinical practices, massive semantic annotations are difficult to acquire in some conditions where specialized biomedical expert knowledge is required, and it is also a common condition where only few annotated classes are available. In this work, we proposed a novel method for few-shot medical image segmentation, which enables a segmentation model to fast generalize to an unseen class with few training images. We construct our few-shot image segmentor using a deep convolutional network trained episodically. Motivated by the spatial consistency and regularity in medical images, we developed an efficient global correlation module to capture the correlation between a support and query image and incorporate it into the deep network called global correlation network. Moreover, we enhance discriminability of deep embedding to encourage clustering of the feature domains of the same class while keep the feature domains of different organs far apart. Ablation Study proved the effectiveness of the proposed global correlation module and discriminative embedding loss. Extensive experiments on anatomical abdomen images on both CT and MRI modalities are performed to demonstrate the state-of-the-art performance of our proposed model.