Dan He

Dan He, Weisheng Li, Guofen Wang et al.

Multimodal medical image fusion (MMIF) extracts the most meaningful information from multiple source images, enabling a more comprehensive and accurate diagnosis. Achieving high-quality fusion results requires a careful balance of brightness, color, contrast, and detail; this ensures that the fused images effectively display relevant anatomical structures and reflect the functional status of the tissues. However, existing MMIF methods have limited capacity to capture detailed features during conventional training and suffer from insufficient cross-modal feature interaction, leading to suboptimal fused image quality. To address these issues, this study proposes a two-stage diffusion model-based fusion network (DM-FNet) to achieve unified MMIF. In Stage I, a diffusion process trains UNet for image reconstruction. UNet captures detailed information through progressive denoising and represents multilevel data, providing a rich set of feature representations for the subsequent fusion network. In Stage II, noisy images at various steps are input into the fusion network to enhance the model's feature recognition capability. Three key fusion modules are also integrated to process medical images from different modalities adaptively. Ultimately, the robust network structure and a hybrid loss function are integrated to harmonize the fused image's brightness, color, contrast, and detail, enhancing its quality and information density. The experimental results across various medical image types demonstrate that the proposed method performs exceptionally well regarding objective evaluation metrics. The fused image preserves appropriate brightness, a comprehensive distribution of radioactive tracers, rich textures, and clear edges. The code is available at https://github.com/HeDan-11/DM-FNet.

Dan He, Guofen Wang, Weisheng Li et al.

Multimodal image fusion (MMIF) aims to integrate information from different modalities to obtain a comprehensive image, aiding downstream tasks. However, existing methods tend to prioritize natural image fusion and focus on information complementary and network training strategies. They ignore the essential distinction between natural and medical image fusion and the influence of underlying components. This paper dissects the significant differences between the two tasks regarding fusion goals, statistical properties, and data distribution. Based on this, we rethink the suitability of the normalization strategy and convolutional kernels for end-to-end MMIF.Specifically, this paper proposes a mixture of instance normalization and group normalization to preserve sample independence and reinforce intrinsic feature correlation.This strategy promotes the potential of enriching feature maps, thus boosting fusion performance. To this end, we further introduce the large kernel convolution, effectively expanding receptive fields and enhancing the preservation of image detail. Moreover, the proposed multipath adaptive fusion module recalibrates the decoder input with features of various scales and receptive fields, ensuring the transmission of crucial information. Extensive experiments demonstrate that our method exhibits state-of-the-art performance in multiple fusion tasks and significantly improves downstream applications. The code is available at https://github.com/HeDan-11/LKC-FUNet.

Rui Xue, Dan He, Fengmei Jin et al.

Detecting trajectory anomalies is a vital task in modern Intelligent Transportation Systems (ITS), enabling the identification of unsafe, inefficient, or irregular travel behaviours. While deep learning has emerged as the dominant approach, several key challenges remain unresolved. First, sub-trajectory anomaly detection, capable of pinpointing the precise segments where anomalies occur, remains underexplored compared to whole-trajectory analysis. Second, many existing methods depend on carefully tuned thresholds, limiting their adaptability in real-world applications. Moreover, the irregular sampling of trajectory data and the presence of noise in training sets further degrade model performance, making it difficult to learn reliable representations of normal routes. To address these challenges, we propose a contrastive reinforcement learning framework for online trajectory anomaly detection, CroTad. Our method is threshold-free and robust to noisy, irregularly sampled data. By incorporating contrastive learning, CroTad learns to extract diverse normal travel patterns for different itineraries and effectively distinguish anomalous behaviours at both sub-trajectory and point levels. The detection module leverages deep reinforcement learning to perform online, real-time anomaly scoring, enabling timely and fine-grained identification of abnormal segments. Extensive experiments on two real-world datasets demonstrate the effectiveness and robustness of our framework across various evaluation scenarios.

Dan He, Irina Rish, David Haws et al.

Whole genome prediction of complex phenotypic traits using high-density genotyping arrays has attracted a great deal of attention, as it is relevant to the fields of plant and animal breeding and genetic epidemiology. As the number of genotypes is generally much bigger than the number of samples, predictive models suffer from the curse-of-dimensionality. The curse-of-dimensionality problem not only affects the computational efficiency of a particular genomic selection method, but can also lead to poor performance, mainly due to correlation among markers. In this work we proposed the first transductive feature selection method based on the MRMR (Max-Relevance and Min-Redundancy) criterion which we call MINT. We applied MINT on genetic trait prediction problems and showed that in general MINT is a better feature selection method than the state-of-the-art inductive method mRMR.