Di Zhu

Di Zhu, Yu Yvonne Wu, Hong Jia et al.

Wearable devices enable continuous monitoring of physiological signals such as ECG and PPG, but existing mHealth systems are largely limited to task-specific prediction pipelines or reactive question answering over static summaries. They lack the ability to support temporal reasoning, persistent physiological context, and proactive monitoring over long-term signal streams. We propose VitalAgent, a tool-augmented agentic framework for ECG/PPG-based mHealth that supports both reactive question answering and proactive monitoring. VitalAgent is built on a longitudinal physiological memory and a tool-augmented reasoning interface that enables dynamic computation over raw signals. We further introduce VitalBench, a longitudinal physiological monitoring benchmark dataset comprising 1,862 QA pairs for reactive question answering and 90.2 hours of continuous ECG/PPG recordings for proactive monitoring, covering cardiac, physical activity, and stress-related tasks. Experiments demonstrate that VitalAgent achieves over 30% improvement over prompt-based and ReAct baselines in reactive evaluation and supports proactive alert monitoring over long-term physiological signals, highlighting the importance of dynamic tool use and long-term physiological monitoring.

Di Zhu, Lei, Zheng et al.

Large language models (LLMs) are increasingly applied in finance, yet most existing work emphasizes trading signals or financial NLP tasks centered on prediction. Institutional fundamental research, by contrast, requires human analysts or AI agents to gather evidence, identify business drivers, compare competing viewpoints, and generate investment memos. Its broader goal is not merely to predict outcomes, but to produce investment plans that are transparent, reusable, and verifiable, while contributing to the cumulative development of investment knowledge. We present FundaPod, a multi-persona agent platform for AI-assisted fundamental investment research. We argue that fundamental research is a human-centric decision-support task that is qualitatively distinct from trading-signal generation, and is therefore better served by an independence-preserving architecture. In FundaPod, AI agents with different personas, such as value investors or macro strategists, conduct research independently under a shared provenance contract. Their disagreements are then surfaced post hoc for adjudication by the human portfolio manager (PM) through a knowledge-graph memory system. This paper contributes five design principles for human-AI hybrid systems supporting fundamental research, grounded in design-science practice and theories of cognitive isolation and human-machine coordination. It also describes four architectural mechanisms: a persona distillation pipeline that turns public investor materials into deployable agents; a declarative skill registry that lets the planner derive typed task graphs; a grounded evidence model that links memo claims to verifiable sources; and a knowledge-graph "second brain" that connects tickers, memos, analysts, and themes. We demonstrate the architecture through a complete case study and a persona-based memo comparison.

Di Zhu, Zixuan Li

Distributional metrics such as Fréchet Audio Distance cannot score individual music clips and correlate poorly with human judgments, while the only per-sample learned metric achieving high human correlation is closed-source. We introduce MUQ-EVAL, an open-source per-sample quality metric for AIgenerated music built by training lightweight prediction heads on frozen MuQ-310M features using MusicEval, a dataset of generated clips from 31 text-to-music systems with expert quality ratings. Our simplest model, frozen features with attention pooling and a two-layer MLP, achieves system-level SRCC = 0.957 and utterance-level SRCC = 0.838 with human mean opinion scores. A systematic ablation over training objectives and adaptation strategies shows that no addition meaningfully improves the frozen baseline, indicating that frozen MuQ representations already capture quality-relevant information. Encoder choice is the dominant design factor, outweighing all architectural and training decisions. LoRA-adapted models trained on as few as 150 clips already achieve usable correlation, enabling personalized quality evaluators from individual listener annotations. A controlled degradation analysis reveals selective sensitivity to signal-level artifacts but insensitivity to musical-structural distortions. Our metric, MUQ-EVAL, is fully open-source, outperforms existing open per-sample metrics, and runs in real time on a single consumer GPU. Code, model weights, and evaluation scripts are available at https://github.com/dgtql/MuQ-Eval.

Md Khairul Islam, Di Zhu, Yingzheng Liu et al.

Interpretable machine learning plays a key role in healthcare because it is challenging in understanding feature importance in deep learning model predictions. We propose a novel framework that uses deep learning to study feature sensitivity for model predictions. This work combines sensitivity analysis with heterogeneous time-series deep learning model prediction, which corresponds to the interpretations of spatio-temporal features. We forecast county-level COVID-19 infection using the Temporal Fusion Transformer. We then use the sensitivity analysis extending Morris Method to see how sensitive the outputs are with respect to perturbation to our static and dynamic input features. The significance of the work is grounded in a real-world COVID-19 infection prediction with highly non-stationary, finely granular, and heterogeneous data. 1) Our model can capture the detailed daily changes of temporal and spatial model behaviors and achieves high prediction performance compared to a PyTorch baseline. 2) By analyzing the Morris sensitivity indices and attention patterns, we decipher the meaning of feature importance with observational population and dynamic model changes. 3) We have collected 2.5 years of socioeconomic and health features over 3142 US counties, such as observed cases and deaths, and a number of static (age distribution, health disparity, and industry) and dynamic features (vaccination, disease spread, transmissible cases, and social distancing). Using the proposed framework, we conduct extensive experiments and show our model can learn complex interactions and perform predictions for daily infection at the county level. Being able to model the disease infection with a hybrid prediction and description accuracy measurement with Morris index at the county level is a central idea that sheds light on individual feature interpretation via sensitivity analysis.

Yanqing Kang, Di Zhu, Haiyang Zhang et al.

Studying influential nodes (I-nodes) in brain networks is of great significance in the field of brain imaging. Most existing studies consider brain connectivity hubs as I-nodes. However, this approach relies heavily on prior knowledge from graph theory, which may overlook the intrinsic characteristics of the brain network, especially when its architecture is not fully understood. In contrast, self-supervised deep learning can learn meaningful representations directly from the data. This approach enables the exploration of I-nodes for brain networks, which is also lacking in current studies. This paper proposes a Self-Supervised Graph Reconstruction framework based on Graph-Transformer (SSGR-GT) to identify I-nodes, which has three main characteristics. First, as a self-supervised model, SSGR-GT extracts the importance of brain nodes to the reconstruction. Second, SSGR-GT uses Graph-Transformer, which is well-suited for extracting features from brain graphs, combining both local and global characteristics. Third, multimodal analysis of I-nodes uses graph-based fusion technology, combining functional and structural brain information. The I-nodes we obtained are distributed in critical areas such as the superior frontal lobe, lateral parietal lobe, and lateral occipital lobe, with a total of 56 identified across different experiments. These I-nodes are involved in more brain networks than other regions, have longer fiber connections, and occupy more central positions in structural connectivity. They also exhibit strong connectivity and high node efficiency in both functional and structural networks. Furthermore, there is a significant overlap between the I-nodes and both the structural and functional rich-club. These findings enhance our understanding of the I-nodes within the brain network, and provide new insights for future research in further understanding the brain working mechanisms.

Yiting Wang, Ziwei Wang, Di Zhu et al.

Small Language Models (SLMs) are a practical option for narrow, workflow-relevant medical imaging utilities where privacy, latency, and cost dominate. We present a governance-ready recipe that combines prompt scaffolds, calibrated abstention, and standards-compliant integration into Picture Archiving and Communication Systems (PACS). Our focus is the assistive task of AP/PA view tagging for chest radiographs. Using four deployable SLMs (Qwen2.5-VL, MiniCPM-V, Gemma 7B, LLaVA 7B) on NIH Chest X-ray, we provide illustrative evidence: reflection-oriented prompts benefit lighter models, whereas stronger baselines are less sensitive. Beyond accuracy, we operationalize abstention, expected calibration error, and oversight burden, and we map outputs to DICOM tags, HL7 v2 messages, and FHIR ImagingStudy. The contribution is a prompt-first deployment framework, an operations playbook for calibration, logging, and change management, and a clear pathway from pilot utilities to reader studies without over-claiming clinical validation. We additionally specify a human-factors RACI, stratified calibration for dataset shift, and an auditable evidence pack to support local governance reviews.

Liu Jiang, Zerui Bao, Shiqi Sheng et al.

Large-scale networked services rely on deep soft-ware stacks and microservice orchestration, which increase instruction footprints and create frontend stalls that inflate tail latency and energy. We revisit instruction prefetching for these cloud workloads and present a design that aligns with SLO driven and self optimizing systems. Building on the Entangling Instruction Prefetcher (EIP), we introduce a Compressed Entry that captures up to eight destinations around a base using 36 bits by exploiting spatial clustering, and a Hierarchical Metadata Storage scheme that keeps only L1 resident and frequently queried entries on chip while virtualizing bulk metadata into lower levels. We further add a lightweight Online ML Controller that scores prefetch profitability using context features and a bandit adjusted threshold. On data center applications, our approach preserves EIP like speedups with smaller on chip state and improves efficiency for networked services in the ML era.

Jiachen Zhong, Yiting Wang, Di Zhu et al.

Lung cancer remains one of the most prevalent and fatal diseases worldwide, demanding accurate and timely diagnosis and treatment. Recent advancements in large AI models have significantly enhanced medical image understanding and clinical decision-making. This review systematically surveys the state-of-the-art in applying large AI models to lung cancer screening, diagnosis, prognosis, and treatment. We categorize existing models into modality-specific encoders, encoder-decoder frameworks, and joint encoder architectures, highlighting key examples such as CLIP, BLIP, Flamingo, BioViL-T, and GLoRIA. We further examine their performance in multimodal learning tasks using benchmark datasets like LIDC-IDRI, NLST, and MIMIC-CXR. Applications span pulmonary nodule detection, gene mutation prediction, multi-omics integration, and personalized treatment planning, with emerging evidence of clinical deployment and validation. Finally, we discuss current limitations in generalizability, interpretability, and regulatory compliance, proposing future directions for building scalable, explainable, and clinically integrated AI systems. Our review underscores the transformative potential of large AI models to personalize and optimize lung cancer care.

Hao Guo, Han Wang, Di Zhu et al.

Modeling spatial heterogeneity in the data generation process is essential for understanding and predicting geographical phenomena. Despite their prevalence in geospatial tasks, neural network models usually assume spatial stationarity, which could limit their performance in the presence of spatial process heterogeneity. By allowing model parameters to vary over space, several approaches have been proposed to incorporate spatial heterogeneity into neural networks. However, current geographically weighting approaches are ineffective on graph neural networks, yielding no significant improvement in prediction accuracy. We assume the crux lies in the over-fitting risk brought by a large number of local parameters. Accordingly, we propose to model spatial process heterogeneity at the regional level rather than at the individual level, which largely reduces the number of spatially varying parameters. We further develop a heuristic optimization procedure to learn the region partition adaptively in the process of model training. Our proposed spatial-heterogeneity-aware graph convolutional network, named RegionGCN, is applied to the spatial prediction of county-level vote share in the 2016 US presidential election based on socioeconomic attributes. Results show that RegionGCN achieves significant improvement over the basic and geographically weighted GCNs. We also offer an exploratory analysis tool for the spatial variation of non-linear relationships through ensemble learning of regional partitions from RegionGCN. Our work contributes to the practice of Geospatial Artificial Intelligence (GeoAI) in tackling spatial heterogeneity.

Di Zhu, Chen Xie, Ziwei Wang et al.

New York City reports over one hundred thousand motor vehicle collisions each year, creating substantial injury and public health burden. We present RaX-Crash, a resource efficient and explainable small model pipeline for structured injury severity prediction on the official NYC Motor Vehicle Collisions dataset. RaX-Crash integrates three linked tables with tens of millions of records, builds a unified feature schema in partitioned storage, and trains compact tree based ensembles (Random Forest and XGBoost) on engineered tabular features, which are compared against locally deployed small language models (SLMs) prompted with textual summaries. On a temporally held out test set, XGBoost and Random Forest achieve accuracies of 0.7828 and 0.7794, clearly outperforming SLMs (0.594 and 0.496); class imbalance analysis shows that simple class weighting improves fatal recall with modest accuracy trade offs, and SHAP attribution highlights human vulnerability factors, timing, and location as dominant drivers of predicted severity. Overall, RaX-Crash indicates that interpretable small model ensembles remain strong baselines for city scale injury analytics, while hybrid pipelines that pair tabular predictors with SLM generated narratives improve communication without sacrificing scalability.

Yi Wang, Zhenghong Wang, Fan Zhang et al.

Human activity intensity prediction is crucial to many location-based services. Despite tremendous progress in modeling dynamics of human activity, most existing methods overlook physical constraints of spatial interaction, leading to uninterpretable spatial correlations and over-smoothing phenomenon. To address these limitations, this work proposes a physics-informed deep learning framework, namely Gravity-informed Spatiotemporal Transformer (Gravityformer) by integrating the universal law of gravitation to refine transformer attention. Specifically, it (1) estimates two spatially explicit mass parameters based on spatiotemporal embedding feature, (2) models the spatial interaction in end-to-end neural network using proposed adaptive gravity model to learn the physical constraint, and (3) utilizes the learned spatial interaction to guide and mitigate the over-smoothing phenomenon in transformer attention. Moreover, a parallel spatiotemporal graph convolution transformer is proposed for achieving a balance between coupled spatial and temporal learning. Systematic experiments on six real-world large-scale activity datasets demonstrate the quantitative and qualitative superiority of our model over state-of-the-art benchmarks. Additionally, the learned gravity attention matrix can be not only disentangled and interpreted based on geographical laws, but also improved the generalization in zero-shot cross-region inference. This work provides a novel insight into integrating physical laws with deep learning for spatiotemporal prediction.

Peng Luo, Di Zhu

Urban spaces, though often perceived as discrete communities, are shared by various functional and social groups. Our study introduces a graph-based physics-aware deep learning framework, illuminating the intricate overlapping nature inherent in urban communities. Through analysis of individual mobile phone positioning data at Twin Cities metro area (TCMA) in Minnesota, USA, our findings reveal that 95.7 % of urban functional complexity stems from the overlapping structure of communities during weekdays. Significantly, our research not only quantifies these overlaps but also reveals their compelling correlations with income and racial indicators, unraveling the complex segregation patterns in U.S. cities. As the first to elucidate the overlapping nature of urban communities, this work offers a unique geospatial perspective on looking at urban structures, highlighting the nuanced interplay of socioeconomic dynamics within cities.

Zihan Chen, Lei Nico Zheng, Cheng Lu et al.

ChatGPT has demonstrated remarkable capabilities across various natural language processing (NLP) tasks. However, its potential for inferring dynamic network structures from temporal textual data, specifically financial news, remains an unexplored frontier. In this research, we introduce a novel framework that leverages ChatGPT's graph inference capabilities to enhance Graph Neural Networks (GNN). Our framework adeptly extracts evolving network structures from textual data, and incorporates these networks into graph neural networks for subsequent predictive tasks. The experimental results from stock movement forecasting indicate our model has consistently outperformed the state-of-the-art Deep Learning-based benchmarks. Furthermore, the portfolios constructed based on our model's outputs demonstrate higher annualized cumulative returns, alongside reduced volatility and maximum drawdown. This superior performance highlights the potential of ChatGPT for text-based network inferences and underscores its promising implications for the financial sector.

Xiao Huang, Di Zhu, Fan Zhang et al.

The rapid development of remote sensing techniques provides rich, large-coverage, and high-temporal information of the ground, which can be coupled with the emerging deep learning approaches that enable latent features and hidden geographical patterns to be extracted. This study marks the first attempt to cross-compare performances of popular state-of-the-art deep learning models in estimating population distribution from remote sensing images, investigate the contribution of neighboring effect, and explore the potential systematic population estimation biases. We conduct an end-to-end training of four popular deep learning architectures, i.e., VGG, ResNet, Xception, and DenseNet, by establishing a mapping between Sentinel-2 image patches and their corresponding population count from the LandScan population grid. The results reveal that DenseNet outperforms the other three models, while VGG has the worst performances in all evaluating metrics under all selected neighboring scenarios. As for the neighboring effect, contradicting existing studies, our results suggest that the increase of neighboring sizes leads to reduced population estimation performance, which is found universal for all four selected models in all evaluating metrics. In addition, there exists a notable, universal bias that all selected deep learning models tend to overestimate sparsely populated image patches and underestimate densely populated image patches, regardless of neighboring sizes. The methodological, experimental, and contextual knowledge this study provides is expected to benefit a wide range of future studies that estimate population distribution via remote sensing imagery.

Yafei Song, Di Zhu, Jia Li et al.

In recent years, camera-based localization has been widely used for robotic applications, and most proposed algorithms rely on local features extracted from recorded images. For better performance, the features used for open-loop localization are required to be short-term globally static, and the ones used for re-localization or loop closure detection need to be long-term static. Therefore, the motion attribute of a local feature point could be exploited to improve localization performance, e.g., the feature points extracted from moving persons or vehicles can be excluded from these systems due to their unsteadiness. In this paper, we design a fully convolutional network (FCN), named MD-Net, to perform motion attribute estimation and feature description simultaneously. MD-Net has a shared backbone network to extract features from the input image and two network branches to complete each sub-task. With MD-Net, we can obtain the motion attribute while avoiding increasing much more computation. Experimental results demonstrate that the proposed method can learn distinct local feature descriptor along with motion attribute only using an FCN, by outperforming competing methods by a wide margin. We also show that the proposed algorithm can be integrated into a vision-based localization algorithm to improve estimation accuracy significantly.

Di Zhu, Yu Liu

The understanding of geographical reality is a process of data representation and pattern discovery. Former studies mainly adopted continuous-field models to represent spatial variables and to investigate the underlying spatial continuity/heterogeneity in the regular spatial domain. In this article, we introduce a more generalized model based on graph convolutional neural networks (GCNs) that can capture the complex parameters of spatial patterns underlying graph-structured spatial data, which generally contain both Euclidean spatial information and non-Euclidean feature information. A trainable semi-supervised prediction framework is proposed to model the spatial distribution patterns of intra-urban points of interest(POI) check-ins. This work demonstrates the feasibility of GCNs in complex geographic decision problems and provides a promising tool to analyze irregular spatial data.