Vincent Roca

Vincent Roca, Martin Bretzner, Hilde Henon et al.

Accurate delineation of acute ischemic stroke lesions in MRI is a key component of stroke diagnosis and management. In recent years, deep learning models have been successfully applied to the automatic segmentation of such lesions. While most proposed architectures are based on the U-Net framework, they primarily differ in their choice of loss functions and in the use of deep supervision, residual connections, and attention mechanisms. Moreover, many implementations are not publicly available, and the optimal configuration for acute ischemic stroke (AIS) lesion segmentation remains unclear. In this work, we introduce ISLA (Ischemic Stroke Lesion Analyzer), a new deep learning model for AIS lesion segmentation from diffusion MRI, trained on three multicenter databases totaling more than 1500 AIS participants. Through systematic optimization of the loss function, convolutional architecture, deep supervision, and attention mechanisms, we developed a robust segmentation framework. We further investigated unsupervised domain adaptation to improve generalization to an external clinical dataset. ISLA outperformed two state-of-the-art approaches for AIS lesion segmentation on an external test set. Codes and trained models will be made publicly available to facilitate reuse and reproducibility.

Vincent Roca, Grégory Kuchcinski, Jean-Pierre Pruvo et al.

In MRI studies, the aggregation of imaging data from multiple acquisition sites enhances sample size but may introduce site-related variabilities that hinder consistency in subsequent analyses. Deep learning methods for image translation have emerged as a solution for harmonizing MR images across sites. In this study, we introduce IGUANe (Image Generation with Unified Adversarial Networks), an original 3D model that leverages the strengths of domain translation and straightforward application of style transfer methods for multicenter brain MR image harmonization. IGUANe extends CycleGAN by integrating an arbitrary number of domains for training through a many-to-one architecture. The framework based on domain pairs enables the implementation of sampling strategies that prevent confusion between site-related and biological variabilities. During inference, the model can be applied to any image, even from an unknown acquisition site, making it a universal generator for harmonization. Trained on a dataset comprising T1-weighted images from 11 different scanners, IGUANe was evaluated on data from unseen sites. The assessments included the transformation of MR images with traveling subjects, the preservation of pairwise distances between MR images within domains, the evolution of volumetric patterns related to age and Alzheimer$'$s disease (AD), and the performance in age regression and patient classification tasks. Comparisons with other harmonization and normalization methods suggest that IGUANe better preserves individual information in MR images and is more suitable for maintaining and reinforcing variabilities related to age and AD. Future studies may further assess IGUANe in other multicenter contexts, either using the same model or retraining it for applications to different image modalities. IGUANe is available at https://github.com/RocaVincent/iguane_harmonization.git.

Vincent Roca, Marc Tommasi, Paul Andrey et al.

$\textbf{Objective:}$ Brain-predicted age difference (BrainAGE) is a neuroimaging biomarker reflecting brain health. However, training robust BrainAGE models requires large datasets, often restricted by privacy concerns. This study evaluates the performance of federated learning (FL) for BrainAGE estimation in ischemic stroke patients treated with mechanical thrombectomy, and investigates its association with clinical phenotypes and functional outcomes. $\textbf{Methods:}$ We used FLAIR brain images from 1674 stroke patients across 16 hospital centers. We implemented standard machine learning and deep learning models for BrainAGE estimates under three data management strategies: centralized learning (pooled data), FL (local training at each site), and single-site learning. We reported prediction errors and examined associations between BrainAGE and vascular risk factors (e.g., diabetes mellitus, hypertension, smoking), as well as functional outcomes at three months post-stroke. Logistic regression evaluated BrainAGE's predictive value for these outcomes, adjusting for age, sex, vascular risk factors, stroke severity, time between MRI and arterial puncture, prior intravenous thrombolysis, and recanalisation outcome. $\textbf{Results:}$ While centralized learning yielded the most accurate predictions, FL consistently outperformed single-site models. BrainAGE was significantly higher in patients with diabetes mellitus across all models. Comparisons between patients with good and poor functional outcomes, and multivariate predictions of these outcomes showed the significance of the association between BrainAGE and post-stroke recovery. $\textbf{Conclusion:}$ FL enables accurate age predictions without data centralization. The strong association between BrainAGE, vascular risk factors, and post-stroke recovery highlights its potential for prognostic modeling in stroke care.

Cristiana Santos, Midas Nouwens, Michael Toth et al.

Consent Management Providers (CMPs) provide consent pop-ups that are embedded in ever more websites over time to enable streamlined compliance with the legal requirements for consent mandated by the ePrivacy Directive and the General Data Protection Regulation (GDPR). They implement the standard for consent collection from the Transparency and Consent Framework (TCF) (current version v2.0) proposed by the European branch of the Interactive Advertising Bureau (IAB Europe). Although the IAB's TCF specifications characterize CMPs as data processors, CMPs factual activities often qualifies them as data controllers instead. Discerning their clear role is crucial since compliance obligations and CMPs liability depend on their accurate characterization. We perform empirical experiments with two major CMP providers in the EU: Quantcast and OneTrust and paired with a legal analysis. We conclude that CMPs process personal data, and we identify multiple scenarios wherein CMPs are controllers.

Claude Castelluccia, Nataliia Bielova, Antoine Boutet et al.

This document presents an evolution of the ROBERT protocol that decentralizes most of its operations on the mobile devices. DESIRE is based on the same architecture than ROBERT but implements major privacy improvements. In particular, it introduces the concept of Private Encounter Tokens, that are secret and cryptographically generated, to encode encounters. In the DESIRE protocol, the temporary Identifiers that are broadcast on the Bluetooth interfaces are generated by the mobile devices providing more control to the users about which ones to disclose. The role of the server is merely to match PETs generated by diagnosed users with the PETs provided by requesting users. It stores minimal pseudonymous data. Finally, all data that are stored on the server are encrypted using keys that are stored on the mobile devices, protecting against data breach on the server. All these modifications improve the privacy of the scheme against malicious users and authority. However, as in the first version of ROBERT, risk scores and notifications are still managed and controlled by the server of the health authority, which provides high robustness, flexibility, and efficacy.

Jagdish Prasad Achara, Vincent Roca, Claude Castelluccia et al.

Smartphones, the devices we carry everywhere with us, are being heavily tracked and have undoubtedly become a major threat to our privacy. As "tracking the trackers" has become a necessity, various static and dynamic analysis tools have been developed in the past. However, today, we still lack suitable tools to detect, measure and compare the ongoing tracking across mobile OSs. To this end, we propose MobileAppScrutinator, based on a simple yet efficient dynamic analysis approach, that works on both Android and iOS (the two most popular OSs today). To demonstrate the current trend in tracking, we select 140 most representative Apps available on both Android and iOS AppStores and test them with MobileAppScrutinator. In fact, choosing the same set of apps on both Android and iOS also enables us to compare the ongoing tracking on these two OSs. Finally, we also discuss the effectiveness of privacy safeguards available on Android and iOS. We show that neither Android nor iOS privacy safeguards in their present state are completely satisfying.

Pierre-Ugo Tournoux, Tuan Tran Thai, Emmanuel Lochin et al.

The use of real-time applications over the Internet is a challenging problem that the QoS epoch attempted to solve by proposing the DiffServ architecture. Today, the only existing service provided by the Internet is still best-effort. As a result, multimedia applications often perform on top of a transport layer that provides a variable sending rate. In an obvious manner, this variable sending rate is an issue for these applications with strong delay constraint. In a real-time context where retransmission can not be used to ensure reliability, video quality suffers from any packet losses. In this position paper, we discuss this problem and motivate why we want to bring out a certain class of erasure coding scheme inside multimedia congestion control protocols such as TFRC.