Weidong Li

Xiaojing Guo, Jiatai Lin, Yumian Jia et al.

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on approximately 210 million histopathology tiles from over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 24 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms three leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 21 of 24 internal validation tasks and in 5 of 10 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system.

Shangshang Yang, Congyi Nai, Xinyan Liu et al.

Machine learning models have shown great success in predicting weather up to two weeks ahead, outperforming process-based benchmarks. However, existing approaches mostly focus on the prediction task, and do not incorporate the necessary data assimilation. Moreover, these models suffer from error accumulation in long roll-outs, limiting their applicability to seasonal predictions or climate projections. Here, we introduce Generative Assimilation and Prediction (GAP), a unified deep generative framework for assimilation and prediction of both weather and climate. By learning to quantify the probabilistic distribution of atmospheric states under observational, predictive, and external forcing constraints, GAP excels in a broad range of weather-climate related tasks, including data assimilation, seamless prediction, and climate simulation. In particular, GAP is competitive with state-of-the-art ensemble assimilation, probabilistic weather forecast and seasonal prediction, yields stable millennial simulations, and reproduces climate variability from daily to decadal time scales.

Libo Zhang, Yang Chen, Toru Takisaka et al.

Sequential Resource Allocation with situational constraints presents a significant challenge in real-world applications, where resource demands and priorities are context-dependent. This paper introduces a novel framework, SCRL, to address this problem. We formalize situational constraints as logic implications and develop a new algorithm that dynamically penalizes constraint violations. To handle situational constraints effectively, we propose a probabilistic selection mechanism to overcome limitations of traditional constraint reinforcement learning (CRL) approaches. We evaluate SCRL across two scenarios: medical resource allocation during a pandemic and pesticide distribution in agriculture. Experiments demonstrate that SCRL outperforms existing baselines in satisfying constraints while maintaining high resource efficiency, showcasing its potential for real-world, context-sensitive decision-making tasks.

Hui Liu, Bo Zhao, Yuefeng Peng et al.

Deep neural networks (DNNs) are threatened by adversarial examples. Adversarial detection, which distinguishes adversarial images from benign images, is fundamental for robust DNN-based services. Image transformation is one of the most effective approaches to detect adversarial examples. During the last few years, a variety of image transformations have been studied and discussed to design reliable adversarial detectors. In this paper, we systematically synthesize the recent progress on adversarial detection via image transformations with a novel classification method. Then, we conduct extensive experiments to test the detection performance of image transformations against state-of-the-art adversarial attacks. Furthermore, we reveal that each individual transformation is not capable of detecting adversarial examples in a robust way, and propose a DNN-based approach referred to as \emph{AdvJudge}, which combines scores of 9 image transformations. Without knowing which individual scores are misleading or not misleading, AdvJudge can make the right judgment, and achieve a significant improvement in detection rate. Finally, we utilize an explainable AI tool to show the contribution of each image transformation to adversarial detection. Experimental results show that the contribution of image transformations to adversarial detection is significantly different, the combination of them can significantly improve the generic detection ability against state-of-the-art adversarial attacks.