Isha Das

Md. Arifur Rahman, Isha Das, Mushfiqur Rahman Abir et al.

Personalized Federated Learning (PFL) constitutes a novel paradigm that tailors Machine Learning (ML) models to individual clients, thereby furnishing personalized model updates whilst upholding stringent data privacy principles. Diverging from conventional standard Federated Learning (FL) approaches, PFL adapts models to distinct client data distributions, engendering heightened levels of accuracy, customization, and data security, all while minimizing communication overhead. This methodology proves particularly salient in contexts marked by pattern recognition tasks reliant upon heterogeneous data sources and underpinned by paramount privacy apprehensions. In the present research endeavor, this article undertake a comprehensive comparative analysis of seven distinct PFL algorithms deployed across three diverse datasets, namely MNIST, SignMNIST, and Digit5. The overarching objective entails ascertaining the preeminent PFL algorithm, within the framework of pattern recognition tasks, through a rigorous evaluation anchored in metrics encompassing Accuracy, Precision, Recall, and F1 Score. Concurrently, an in-depth scrutiny of these PFL algorithms is conducted, elucidating their operative workflows, advantages, and limitations. Through empirical investigation, the findings evince that APPLE, FedGC, and FedProto emerge as stalwart contenders, consistently furnishing superior performance across the spectrum of assessed datasets, while acknowledging the contextual specificity of alternative algorithms and the potential for iterative refinement to realize optimal outcomes.

Vineet K Raghu, Xiaoyu Ge, Arun Balajee et al.

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level. However, to truly understand causes of disease and the effects of medical interventions, this data must be integrated with phenotypic, environmental, and behavioral data from individuals. Further, effective knowledge discovery methods that can infer relationships between these data types are required. In this work, we propose a pipeline for knowledge discovery from integrated genomic and clinical data. The pipeline begins with a novel variable selection method, and uses a probabilistic graphical model to understand the relationships between features in the data. We demonstrate how this pipeline can improve breast cancer outcome prediction models, and can provide a biologically interpretable view of sequencing data.