Yunpeng Zhao

Yunpeng Zhao, Fugen Zhou, Bin Guo et al.

Graph neural networks (GNNs) have been successfully applied to early mild cognitive impairment (EMCI) detection, with the usage of elaborately designed features constructed from blood oxygen level-dependent (BOLD) time series. However, few works explored the feasibility of using BOLD signals directly as features. Meanwhile, existing GNN-based methods primarily rely on hand-crafted explicit brain topology as the adjacency matrix, which is not optimal and ignores the implicit topological organization of the brain. In this paper, we propose a spatial temporal graph convolutional network with a novel graph structure self-learning mechanism for EMCI detection. The proposed spatial temporal graph convolution block directly exploits BOLD time series as input features, which provides an interesting view for rsfMRI-based preclinical AD diagnosis. Moreover, our model can adaptively learn the optimal topological structure and refine edge weights with the graph structure self-learning mechanism. Results on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database show that our method outperforms state-of-the-art approaches. Biomarkers consistent with previous studies can be extracted from the model, proving the reliable interpretability of our method.

Yunpeng Zhao, Ning Hao, Ji Zhu

Bipartite graphs are ubiquitous across various scientific and engineering fields. Simultaneously grouping the two types of nodes in a bipartite graph via biclustering represents a fundamental challenge in network analysis for such graphs. The latent block model (LBM) is a commonly used model-based tool for biclustering. However, the effectiveness of the LBM is often limited by the influence of row and column sums in the data matrix. To address this limitation, we introduce the degree-corrected latent block model (DC-LBM), which accounts for the varying degrees in row and column clusters, significantly enhancing performance on real-world data sets and simulated data. We develop an efficient variational expectation-maximization algorithm by creating closed-form solutions for parameter estimates in the M steps. Furthermore, we prove the label consistency and the rate of convergence of the variational estimator under the DC-LBM, allowing the expected graph density to approach zero as long as the average expected degrees of rows and columns approach infinity when the size of the graph increases.