Anthony Song

Anthony Song, Boyan Zhou, Mayank Golhar et al.

Three-dimensional (3D) histopathology of unprocessed tissues has the potential to transform disease management by enabling volumetric characterization of tissue microarchitecture and in-vivo assessment. Back-illumination Interference Tomography (BIT) is a new phase microscopy technology that provides rapid, non-destructive volumetric imaging of unprocessed tissues. However, translating BIT volumes into clinically interpretable H&E images remains challenging, particularly due to shift-variant contrast and the absence of quantitative validation benchmarks. We introduce HistoBIT3D, the first voxel-wise paired BIT and fluorescence-labeled nuclei dataset, enabling quantitative evaluation of structural preservation in unsupervised virtual staining against ground-truth nuclear distributions. Using this dataset, we present a novel virtual staining framework that translates BIT volumes with shift-variant contrast into realistic H&E volumes by leveraging bidirectional multiscale content consistency and cross-domain style reuse to enhance structural fidelity and perceptual realism. Our method achieves state-of-the-art realism metrics while significantly improving 3D nuclei segmentation accuracy and boundary preservation under zero-shot Cellpose evaluation. Together, these contributions establish a quantitatively validated, structurally faithful, and scalable pipeline for 3D virtual H&E staining, advancing the paradigm of slide-free, volumetric computational histopathology. Our data and code are available at: https://github.com/aasong113/HistoBIT3D_VirtualStaining.

Rajat Kumar Jenamani, Tom Silver, Ben Dodson et al.

Physical caregiving robots hold promise for improving the quality of life of millions worldwide who require assistance with feeding. However, in-home meal assistance remains challenging due to the diversity of activities (e.g., eating, drinking, mouth wiping), contexts (e.g., socializing, watching TV), food items, and user preferences that arise during deployment. In this work, we propose FEAST, a flexible mealtime-assistance system that can be personalized in-the-wild to meet the unique needs of individual care recipients. Developed in collaboration with two community researchers and informed by a formative study with a diverse group of care recipients, our system is guided by three key tenets for in-the-wild personalization: adaptability, transparency, and safety. FEAST embodies these principles through: (i) modular hardware that enables switching between assisted feeding, drinking, and mouth-wiping, (ii) diverse interaction methods, including a web interface, head gestures, and physical buttons, to accommodate diverse functional abilities and preferences, and (iii) parameterized behavior trees that can be safely and transparently adapted using a large language model. We evaluate our system based on the personalization requirements identified in our formative study, demonstrating that FEAST offers a wide range of transparent and safe adaptations and outperforms a state-of-the-art baseline limited to fixed customizations. To demonstrate real-world applicability, we conduct an in-home user study with two care recipients (who are community researchers), feeding them three meals each across three diverse scenarios. We further assess FEAST's ecological validity by evaluating with an Occupational Therapist previously unfamiliar with the system. In all cases, users successfully personalize FEAST to meet their individual needs and preferences. Website: https://emprise.cs.cornell.edu/feast