Yu Pang

Jiaqian Wang, Yutao Qi, Wenjin Hou et al.

Text-to-SQL enables non-expert users to query databases in natural language, yet real-world schemas often suffer from ambiguous, abbreviated, or inconsistent naming conventions that degrade model accuracy. Existing approaches treat schemas as fixed and address errors downstream. In this paper, we frame schema refinement as a constrained optimization problem: find a renaming function that maximizes downstream Text-to-SQL execution accuracy while preserving query equivalence through database views. We analyze the computational hardness of this problem, which motivates a column-wise greedy decomposition, and instantiate it as EGRefine: a four-phase pipeline that screens ambiguous columns, generates context-aware candidate names, verifies them through execution-grounded feedback, and materializes the result as non-destructive SQL views. The pipeline carries two structural properties: column-local non-degradation, ensured by the conservative selection rule in the verification phase, and database-level query equivalence, ensured by the view-based materialization phase. Together they make the resulting refinement safe by construction at the column level, with cross-column and prompt-level interactions handled empirically rather than analytically. Across controlled schema-degradation, real-world, and enterprise benchmarks, EGRefine recovers accuracy lost to schema naming noise where applicable and correctly abstains where the underlying task exceeds current Text-to-SQL capabilities, with refined schemas transferring across model families to enable refine-once, serve-many-models deployment. Code and data are publicly available at https://github.com/ai-jiaqian/EGRefine.

Liye Chen, Biaoshun Li, Yihao Chen et al.

Antibody-drug conjugate (ADC) has revolutionized the field of cancer treatment in the era of precision medicine due to their ability to precisely target cancer cells and release highly effective drug. Nevertheless, the realization of rational design of ADC is very difficult because the relationship between their structures and activities is difficult to understand. In the present study, we introduce a unified deep learning framework called ADCNet to help design potential ADCs. The ADCNet highly integrates the protein representation learning language model ESM-2 and small-molecule representation learning language model FG-BERT models to achieve activity prediction through learning meaningful features from antigen and antibody protein sequences of ADC, SMILES strings of linker and payload, and drug-antibody ratio (DAR) value. Based on a carefully designed and manually tailored ADC data set, extensive evaluation results reveal that ADCNet performs best on the test set compared to baseline machine learning models across all evaluation metrics. For example, it achieves an average prediction accuracy of 87.12%, a balanced accuracy of 0.8689, and an area under receiver operating characteristic curve of 0.9293 on the test set. In addition, cross-validation, ablation experiments, and external independent testing results further prove the stability, advancement, and robustness of the ADCNet architecture. For the convenience of the community, we develop the first online platform (https://ADCNet.idruglab.cn) for the prediction of ADCs activity based on the optimal ADCNet model, and the source code is publicly available at https://github.com/idrugLab/ADCNet.

Yun Liu, Jintu Huang, Yingying Zhu et al.

Peptide-drug conjugates (PDCs) represent a promising therapeutic avenue for human diseases, particularly in cancer treatment. Systematic elucidation of structure-activity relationships (SARs) and accurate prediction of the activity of PDCs are critical for the rational design and optimization of these conjugates. To this end, we carefully design and construct a benchmark PDCs dataset compiled from literature-derived collections and PDCdb database, and then develop PDCNet, the first unified deep learning framework for forecasting the activity of PDCs. The architecture systematically captures the complex factors underlying anticancer decisions of PDCs in real-word scenarios through a multi-level feature fusion framework that collaboratively characterizes and learns the features of peptides, linkers, and payloads. Leveraging a curated PDCs benchmark dataset, comprehensive evaluation results show that PDCNet demonstrates superior predictive capability, with the highest AUC, F1, MCC and BA scores of 0.9213, 0.7656, 0.7071 and 0.8388 for the test set, outperforming eight established traditional machine learning models. Multi-level validations, including 5-fold cross-validation, threshold testing, ablation studies, model interpretability analysis and external independent testing, further confirm the superiority, robustness, and usability of the PDCNet architecture. We anticipate that PDCNet represents a novel paradigm, incorporating both a benchmark dataset and advanced models, which can accelerate the design and discovery of new PDC-based therapeutic agents.

Daniel Ayepah-Mensah, Guolin Sun, Yu Pang et al.

Network slicing enables industrial Internet of Things (IIoT) networks with multiservice and differentiated resource requirements to meet increasing demands through efficient use and management of network resources. Typically, the network slice orchestrator relies on demand forecasts for each slice to make informed decisions and maximize resource utilization. The new generation of Industry 4.0 has introduced digital twins to map physical systems to digital models for accurate decision-making. In our approach, we first use graph-attention networks to build a digital twin environment for network slices, enabling real-time traffic analysis, monitoring, and demand forecasting. Based on these predictions, we formulate the resource allocation problem as a federated multi-agent reinforcement learning problem and employ a deep deterministic policy gradient to determine the resource allocation policy while preserving the privacy of the slices. Our results demonstrate that the proposed approaches can improve the accuracy of demand prediction for network slices and reduce the communication overhead of dynamic network slicing.

Yu Pang, Xinyi Li, Lin Yuan et al.

Human annotation is always considered as ground truth in video object tracking tasks. It is used in both training and evaluation purposes. Thus, ensuring its high quality is an important task for the success of trackers and evaluations between them. In this paper, we give a qualitative and quantitative analysis of the existing human annotations. We show that human annotation tends to be non-smooth and is prone to partial visibility and deformation. We propose a smoothing trajectory strategy with the ability to handle moving scenes. We use a two-step adaptive image alignment algorithm to find the canonical view of the video sequence. We then use different techniques to smooth the trajectories at certain degree. Once we convert back to the original image coordination, we can compare with the human annotation. With the experimental results, we can get more consistent trajectories. At a certain degree, it can also slightly improve the trained model. If go beyond a certain threshold, the smoothing error will start eating up the benefit. Overall, our method could help extrapolate the missing annotation frames or identify and correct human annotation outliers as well as help improve the training data quality.