Kang Zhou

Yuan Zhong, Chenhui Tang, Yumeng Yang et al.

Eye gaze that reveals human observational patterns has increasingly been incorporated into solutions for vision tasks. Despite recent explorations on leveraging gaze to aid deep networks, few studies exploit gaze as an efficient annotation approach for medical image segmentation which typically entails heavy annotating costs. In this paper, we propose to collect dense weak supervision for medical image segmentation with a gaze annotation scheme. To train with gaze, we propose a multi-level framework that trains multiple networks from discriminative human attention, simulated with a set of pseudo-masks derived by applying hierarchical thresholds on gaze heatmaps. Furthermore, to mitigate gaze noise, a cross-level consistency is exploited to regularize overfitting noisy labels, steering models toward clean patterns learned by peer networks. The proposed method is validated on two public medical datasets of polyp and prostate segmentation tasks. We contribute a high-quality gaze dataset entitled GazeMedSeg as an extension to the popular medical segmentation datasets. To the best of our knowledge, this is the first gaze dataset for medical image segmentation. Our experiments demonstrate that gaze annotation outperforms previous label-efficient annotation schemes in terms of both performance and annotation time. Our collected gaze data and code are available at: https://github.com/med-air/GazeMedSeg.

Junling Liu, Chao Liu, Peilin Zhou et al.

Recently, the fast development of Large Language Models (LLMs) such as ChatGPT has significantly advanced NLP tasks by enhancing the capabilities of conversational models. However, the application of LLMs in the recommendation domain has not been thoroughly investigated. To bridge this gap, we propose LLMRec, a LLM-based recommender system designed for benchmarking LLMs on various recommendation tasks. Specifically, we benchmark several popular off-the-shelf LLMs, such as ChatGPT, LLaMA, ChatGLM, on five recommendation tasks, including rating prediction, sequential recommendation, direct recommendation, explanation generation, and review summarization. Furthermore, we investigate the effectiveness of supervised finetuning to improve LLMs' instruction compliance ability. The benchmark results indicate that LLMs displayed only moderate proficiency in accuracy-based tasks such as sequential and direct recommendation. However, they demonstrated comparable performance to state-of-the-art methods in explainability-based tasks. We also conduct qualitative evaluations to further evaluate the quality of contents generated by different models, and the results show that LLMs can truly understand the provided information and generate clearer and more reasonable results. We aspire that this benchmark will serve as an inspiration for researchers to delve deeper into the potential of LLMs in enhancing recommendation performance. Our codes, processed data and benchmark results are available at https://github.com/williamliujl/LLMRec.

Kang Zhou, Yuepei Li, Qi Li

In this paper, we study the named entity recognition (NER) problem under distant supervision. Due to the incompleteness of the external dictionaries and/or knowledge bases, such distantly annotated training data usually suffer from a high false negative rate. To this end, we formulate the Distantly Supervised NER (DS-NER) problem via Multi-class Positive and Unlabeled (MPU) learning and propose a theoretically and practically novel CONFidence-based MPU (Conf-MPU) approach. To handle the incomplete annotations, Conf-MPU consists of two steps. First, a confidence score is estimated for each token of being an entity token. Then, the proposed Conf-MPU risk estimation is applied to train a multi-class classifier for the NER task. Thorough experiments on two benchmark datasets labeled by various external knowledge demonstrate the superiority of the proposed Conf-MPU over existing DS-NER methods.

Kang Zhou, Qiao Qiao, Yuepei Li et al.

To reduce human annotations for relation extraction (RE) tasks, distantly supervised approaches have been proposed, while struggling with low performance. In this work, we propose a novel DSRE-NLI framework, which considers both distant supervision from existing knowledge bases and indirect supervision from pretrained language models for other tasks. DSRE-NLI energizes an off-the-shelf natural language inference (NLI) engine with a semi-automatic relation verbalization (SARV) mechanism to provide indirect supervision and further consolidates the distant annotations to benefit multi-classification RE models. The NLI-based indirect supervision acquires only one relation verbalization template from humans as a semantically general template for each relationship, and then the template set is enriched by high-quality textual patterns automatically mined from the distantly annotated corpus. With two simple and effective data consolidation strategies, the quality of training data is substantially improved. Extensive experiments demonstrate that the proposed framework significantly improves the SOTA performance (up to 7.73\% of F1) on distantly supervised RE benchmark datasets.

Qiao Qiao, Yuepei Li, Kang Zhou et al.

Few-shot knowledge graph completion (FKGC) task aims to predict unseen facts of a relation with few-shot reference entity pairs. Current approaches randomly select one negative sample for each reference entity pair to minimize a margin-based ranking loss, which easily leads to a zero-loss problem if the negative sample is far away from the positive sample and then out of the margin. Moreover, the entity should have a different representation under a different context. To tackle these issues, we propose a novel Relation-Aware Network with Attention-Based Loss (RANA) framework. Specifically, to better utilize the plentiful negative samples and alleviate the zero-loss issue, we strategically select relevant negative samples and design an attention-based loss function to further differentiate the importance of each negative sample. The intuition is that negative samples more similar to positive samples will contribute more to the model. Further, we design a dynamic relation-aware entity encoder for learning a context-dependent entity representation. Experiments demonstrate that RANA outperforms the state-of-the-art models on two benchmark datasets.

Yuepei Li, Kang Zhou, Qiao Qiao et al.

Distantly-Supervised Named Entity Recognition (DS-NER) uses knowledge bases or dictionaries for annotations, reducing manual efforts but rely on large human labeled validation set. In this paper, we introduce a real-life DS-NER dataset, QTL, where the training data is annotated using domain dictionaries and the test data is annotated by domain experts. This dataset has a small validation set, reflecting real-life scenarios. Existing DS-NER approaches fail when applied to QTL, which motivate us to re-examine existing DS-NER approaches. We found that many of them rely on large validation sets and some used test set for tuning inappropriately. To solve this issue, we proposed a new approach, token-level Curriculum-based Positive-Unlabeled Learning (CuPUL), which uses curriculum learning to order training samples from easy to hard. This method stabilizes training, making it robust and effective on small validation sets. CuPUL also addresses false negative issues using the Positive-Unlabeled learning paradigm, demonstrating improved performance in real-life applications.

Hongye Zeng, Ke Zou, Zhihao Chen et al.

Handheld ultrasound devices face usage limitations due to user inexperience and cannot benefit from supervised deep learning without extensive expert annotations. Moreover, the models trained on standard ultrasound device data are constrained by training data distribution and perform poorly when directly applied to handheld device data. In this study, we propose the Training-free Image Style Alignment (TISA) framework to align the style of handheld device data to those of standard devices. The proposed TISA can directly infer handheld device images without extra training and is suited for clinical applications. We show that TISA performs better and more stably in medical detection and segmentation tasks for handheld device data. We further validate TISA as the clinical model for automatic measurements of spinal curvature and carotid intima-media thickness. The automatic measurements agree well with manual measurements made by human experts and the measurement errors remain within clinically acceptable ranges. We demonstrate the potential for TISA to facilitate automatic diagnosis on handheld ultrasound devices and expedite their eventual widespread use.

Kang Zhou, Jing Li, Weixin Luo et al.

Anomaly detection in medical images refers to the identification of abnormal images with only normal images in the training set. Most existing methods solve this problem with a self-reconstruction framework, which tends to learn an identity mapping and reduces the sensitivity to anomalies. To mitigate this problem, in this paper, we propose a novel Proxy-bridged Image Reconstruction Network (ProxyAno) for anomaly detection in medical images. Specifically, we use an intermediate proxy to bridge the input image and the reconstructed image. We study different proxy types, and we find that the superpixel-image (SI) is the best one. We set all pixels' intensities within each superpixel as their average intensity, and denote this image as SI. The proposed ProxyAno consists of two modules, a Proxy Extraction Module and an Image Reconstruction Module. In the Proxy Extraction Module, a memory is introduced to memorize the feature correspondence for normal image to its corresponding SI, while the memorized correspondence does not apply to the abnormal images, which leads to the information loss for abnormal image and facilitates the anomaly detection. In the Image Reconstruction Module, we map an SI to its reconstructed image. Further, we crop a patch from the image and paste it on the normal SI to mimic the anomalies, and enforce the network to reconstruct the normal image even with the pseudo abnormal SI. In this way, our network enlarges the reconstruction error for anomalies. Extensive experiments on brain MR images, retinal OCT images and retinal fundus images verify the effectiveness of our method for both image-level and pixel-level anomaly detection.

Hong-Ye Zeng, Song-Han Ge, Yu-Chong Gao et al.

Objective: The spinous process angle (SPA) is one of the essential parameters to denote three-dimensional (3-D) deformity of spine. We propose an automatic segmentation method based on Stacked Hourglass Network (SHN) to detect the spinous processes (SP) on ultrasound (US) spine images and to measure the SPAs of clinical scoliotic subjects. Methods: The network was trained to detect vertebral SP and laminae as five landmarks on 1200 ultrasound transverse images and validated on 100 images. All the processed transverse images with highlighted SP and laminae were reconstructed into a 3D image volume, and the SPAs were measured on the projected coronal images. The trained network was tested on 400 images by calculating the percentage of correct keypoints (PCK); and the SPA measurements were evaluated on 50 scoliotic subjects by comparing the results from US images and radiographs. Results: The trained network achieved a high average PCK (86.8%) on the test datasets, particularly the PCK of SP detection was 90.3%. The SPAs measured from US and radiographic methods showed good correlation (r>0.85), and the mean absolute differences (MAD) between two modalities were 3.3°, which was less than the clinical acceptance error (5°). Conclusion: The vertebral features can be accurately segmented on US spine images using SHN, and the measurement results of SPA from US data was comparable to the gold standard from radiography.

Kang Zhou, Yuting Xiao, Jianlong Yang et al.

Anomaly detection in retinal image refers to the identification of abnormality caused by various retinal diseases/lesions, by only leveraging normal images in training phase. Normal images from healthy subjects often have regular structures (e.g., the structured blood vessels in the fundus image, or structured anatomy in optical coherence tomography image). On the contrary, the diseases and lesions often destroy these structures. Motivated by this, we propose to leverage the relation between the image texture and structure to design a deep neural network for anomaly detection. Specifically, we first extract the structure of the retinal images, then we combine both the structure features and the last layer features extracted from original health image to reconstruct the original input healthy image. The image feature provides the texture information and guarantees the uniqueness of the image recovered from the structure. In the end, we further utilize the reconstructed image to extract the structure and measure the difference between structure extracted from original and the reconstructed image. On the one hand, minimizing the reconstruction difference behaves like a regularizer to guarantee that the image is corrected reconstructed. On the other hand, such structure difference can also be used as a metric for normality measurement. The whole network is termed as P-Net because it has a ``P'' shape. Extensive experiments on RESC dataset and iSee dataset validate the effectiveness of our approach for anomaly detection in retinal images. Further, our method also generalizes well to novel class discovery in retinal images and anomaly detection in real-world images.

Huihong Zhang, Jianlong Yang, Kang Zhou et al.

Choroid is the vascular layer of the eye, which is directly related to the incidence and severity of many ocular diseases. Optical Coherence Tomography (OCT) is capable of imaging both the cross-sectional view of retina and choroid, but the segmentation of the choroid region is challenging because of the fuzzy choroid-sclera interface (CSI). In this paper, we propose a biomarker infused global-to-local network (BioNet) for choroid segmentation, which segments the choroid with higher credibility and robustness. Firstly, our method trains a biomarker prediction network to learn the features of the biomarker. Then a global multi-layers segmentation module is applied to segment the OCT image into 12 layers. Finally, the global multi-layered result and the original OCT image are fed into a local choroid segmentation module to segment the choroid region with the biomarker infused as regularizer. We conducted comparison experiments with the state-of-the-art methods on a dataset (named AROD). The experimental results demonstrate the superiority of our method with $90.77\%$ Dice-index and 6.23 pixels Average-unsigned-surface-detection-error, etc.

Kang Zhou, Shenghua Gao, Jun Cheng et al.

With the development of convolutional neural network, deep learning has shown its success for retinal disease detection from optical coherence tomography (OCT) images. However, deep learning often relies on large scale labelled data for training, which is oftentimes challenging especially for disease with low occurrence. Moreover, a deep learning system trained from data-set with one or a few diseases is unable to detect other unseen diseases, which limits the practical usage of the system in disease screening. To address the limitation, we propose a novel anomaly detection framework termed Sparsity-constrained Generative Adversarial Network (Sparse-GAN) for disease screening where only healthy data are available in the training set. The contributions of Sparse-GAN are two-folds: 1) The proposed Sparse-GAN predicts the anomalies in latent space rather than image-level; 2) Sparse-GAN is constrained by a novel Sparsity Regularization Net. Furthermore, in light of the role of lesions for disease screening, we present to leverage on an anomaly activation map to show the heatmap of lesions. We evaluate our proposed Sparse-GAN on a publicly available dataset, and the results show that the proposed method outperforms the state-of-the-art methods.

Kang Zhou, Zaiwang Gu, Wen Liu et al.

Diabetic Retinopathy (DR) is a non-negligible eye disease among patients with Diabetes Mellitus, and automatic retinal image analysis algorithm for the DR screening is in high demand. Considering the resolution of retinal image is very high, where small pathological tissues can be detected only with large resolution image and large local receptive field are required to identify those late stage disease, but directly training a neural network with very deep architecture and high resolution image is both time computational expensive and difficult because of gradient vanishing/exploding problem, we propose a \textbf{Multi-Cell} architecture which gradually increases the depth of deep neural network and the resolution of input image, which both boosts the training time but also improves the classification accuracy. Further, considering the different stages of DR actually progress gradually, which means the labels of different stages are related. To considering the relationships of images with different stages, we propose a \textbf{Multi-Task} learning strategy which predicts the label with both classification and regression. Experimental results on the Kaggle dataset show that our method achieves a Kappa of 0.841 on test set which is the 4-th rank of all state-of-the-arts methods. Further, our Multi-Cell Multi-Task Convolutional Neural Networks (M$^2$CNN) solution is a general framework, which can be readily integrated with many other deep neural network architectures.