Harshil Ratnu

Mohammad Rafayet Ali, Taylor Myers, Ellen Wagner et al.

One of the symptoms of Parkinson's disease (PD) is hypomimia or reduced facial expressions. In this paper, we present a digital biomarker for PD that utilizes the study of micro-expressions. We analyzed the facial action units (AU) from 1812 videos of 604 individuals (61 with PD and 543 without PD, mean age 63.9 yo, sd 7.8 ) collected online using a web-based tool (www.parktest.net). In these videos, participants were asked to make three facial expressions (a smiling, disgusted, and surprised face) followed by a neutral face. Using techniques from computer vision and machine learning, we objectively measured the variance of the facial muscle movements and used it to distinguish between individuals with and without PD. The prediction accuracy using the facial micro-expressions was comparable to those methodologies that utilize motor symptoms. Logistic regression analysis revealed that participants with PD had less variance in AU6 (cheek raiser), AU12 (lip corner puller), and AU4 (brow lowerer) than non-PD individuals. An automated classifier using Support Vector Machine was trained on the variances and achieved 95.6% accuracy. Using facial expressions as a biomarker for PD could be potentially transformative for patients in need of physical separation (e.g., due to COVID) or are immobile.

Wasifur Rahman, Sangwu Lee, Md. Saiful Islam et al.

In this paper, we envision a web-based framework that can help anyone, anywhere around the world record a short speech task, and analyze the recorded data to screen for Parkinson's disease (PD). We collected data from 726 unique participants (262 PD, 38% female; 464 non-PD, 65% female; average age: 61) -- from all over the US and beyond. A small portion of the data was collected in a lab setting to compare quality. The participants were instructed to utter a popular pangram containing all the letters in the English alphabet "the quick brown fox jumps over the lazy dog..". We extracted both standard acoustic features (Mel Frequency Cepstral Coefficients (MFCC), jitter and shimmer variants) and deep learning based features from the speech data. Using these features, we trained several machine learning algorithms. We achieved 0.75 AUC (Area Under The Curve) performance on determining presence of self-reported Parkinson's disease by modeling the standard acoustic features through the XGBoost -- a gradient-boosted decision tree model. Further analysis reveal that the widely used MFCC features and a subset of previously validated dysphonia features designed for detecting Parkinson's from verbal phonation task (pronouncing 'ahh') contains the most distinct information. Our model performed equally well on data collected in controlled lab environment as well as 'in the wild' across different gender and age groups. Using this tool, we can collect data from almost anyone anywhere with a video/audio enabled device, contributing to equity and access in neurological care.