Arefin Ittesafun Abian

Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan, Arefin Ittesafun Abian et al.

Gliomas are among the most aggressive cancers, characterized by high mortality rates and complex diagnostic processes. Existing studies on glioma diagnosis and classification often describe issues such as high variability in imaging data, inadequate optimization of computational resources, and inefficient segmentation and classification of gliomas. To address these challenges, we propose novel techniques utilizing multi-parametric MRI data to enhance tumor segmentation and classification efficiency. Our work introduces the first-ever radiomics-enhanced fused residual multiparametric 3D network (ReFRM3D) for brain tumor characterization, which is based on a 3D U-Net architecture and features multi-scale feature fusion, hybrid upsampling, and an extended residual skip mechanism. Additionally, we propose a multi-feature tumor marker-based classifier that leverages radiomic features extracted from the segmented regions. Experimental results demonstrate significant improvements in segmentation performance across the BraTS2019, BraTS2020, and BraTS2021 datasets, achieving high Dice Similarity Coefficients (DSC) of 94.04%, 92.68%, and 93.64% for whole tumor (WT), enhancing tumor (ET), and tumor core (TC) respectively in BraTS2019; 94.09%, 92.91%, and 93.84% in BraTS2020; and 93.70%, 90.36%, and 92.13% in BraTS2021.

Sayeem Been Zaman, Wasimul Karim, Arefin Ittesafun Abian et al.

The increasing use of synthetic media, particularly deepfakes, is an emerging challenge for digital content verification. Although recent studies use both audio and visual information, most integrate these cues within a single model, which remains vulnerable to modality mismatches, noise, and manipulation. To address this gap, we propose DeepAgent, an advanced multi-agent collaboration framework that simultaneously incorporates both visual and audio modalities for the effective detection of deepfakes. DeepAgent consists of two complementary agents. Agent-1 examines each video with a streamlined AlexNet-based CNN to identify the symbols of deepfake manipulation, while Agent-2 detects audio-visual inconsistencies by combining acoustic features, audio transcriptions from Whisper, and frame-reading sequences of images through EasyOCR. Their decisions are fused through a Random Forest meta-classifier that improves final performance by taking advantage of the different decision boundaries learned by each agent. This study evaluates the proposed framework using three benchmark datasets to demonstrate both component-level and fused performance. Agent-1 achieves a test accuracy of 94.35% on the combined Celeb-DF and FakeAVCeleb datasets. On the FakeAVCeleb dataset, Agent-2 and the final meta-classifier attain accuracies of 93.69% and 81.56%, respectively. In addition, cross-dataset validation on DeepFakeTIMIT confirms the robustness of the meta-classifier, which achieves a final accuracy of 97.49%, and indicates a strong capability across diverse datasets. These findings confirm that hierarchy-based fusion enhances robustness by mitigating the weaknesses of individual modalities and demonstrate the effectiveness of a multi-agent approach in addressing diverse types of manipulations in deepfakes.

Md. Adnanul Islam, Wasimul Karim, Md Mahbub Alam et al.

Accurate weight estimation of commercial and industrial waste is important for efficient operations, yet image-based estimation remains difficult because similar-looking objects may have different densities, and the visible size changes with camera distance. Addressing this problem, we propose Multimodal Weight Predictor (MWP) framework that estimates waste weight by combining RGB images with physics-informed metadata, including object dimensions, camera distance, and camera height. We also introduce Waste-Weight-10K, a real-world dataset containing 10,421 synchronized image-metadata collected from logistics and recycling sites. The dataset covers 11 waste categories and a wide weight range from 3.5 to 3,450 kg. Our model uses a Vision Transformer for visual features and a dedicated metadata encoder for geometric and category information, combining them with Stacked Mutual Attention Fusion that allows visual and physical cues guide each other. This helps the model manage perspective effects and link objects to material properties. To ensure stable performance across the wide weight range, we train the model using Mean Squared Logarithmic Error. On the test set, the proposed method achieves 88.06 kg Mean Absolute Error (MAE), 6.39% Mean Absolute Percentage Error (MAPE), and an R2 coefficient of 0.9548. The model shows strong accuracy for light objects in the 0-100 kg range with 2.38 kg MAE and 3.1% MAPE, maintaining reliable performance for heavy waste in the 1000-2000 kg range with 11.1% MAPE. Finally, we incorporate a physically grounded explanation module using Shapley Additive Explanations (SHAP) and a large language model to provide clear, human-readable explanations for each prediction.

Riasad Alvi, Sayeem Been Zaman, Wasimul Karim et al.

Generative artificial intelligence (GenAI) has become a transformative approach in bioinformatics that often enables advancements in genomics, proteomics, transcriptomics, structural biology, and drug discovery. To systematically identify and evaluate these growing developments, this review proposed six research questions (RQs), according to the preferred reporting items for systematic reviews and meta-analysis methods. The objective is to evaluate impactful GenAI strategies in methodological advancement, predictive performance, and specialization, and to identify promising approaches for advanced modeling, data-intensive discovery, and integrative biological analysis. RQ1 highlights diverse applications across multiple bioinformatics subfields (sequence analysis, molecular design, and integrative data modeling), which demonstrate superior performance over traditional methods through pattern recognition and output generation. RQ2 reveals that adapted specialized model architectures outperformed general-purpose models, an advantage attributed to targeted pretraining and context-aware strategies. RQ3 identifies significant benefits in the bioinformatics domains, focusing on molecular analysis and data integration, which improves accuracy and reduces errors in complex analysis. RQ4 indicates improvements in structural modeling, functional prediction, and synthetic data generation, validated by established benchmarks. RQ5 suggests the main constraints, such as the lack of scalability and biases in data that impact generalizability, and proposes future directions focused on robust evaluation and biologically grounded modeling. RQ6 examines that molecular datasets (such as UniProtKB and ProteinNet12), cellular datasets (such as CELLxGENE and GTEx) and textual resources (such as PubMedQA and OMIM) broadly support the training and generalization of GenAI models.

Riasad Alvi, Mohaimenul Azam Khan Raiaan, Sadia Sultana Chowa et al.

Precision livestock farming requires accurate and timely heat stress prediction to ensure animal welfare and optimize farm management. This study presents a physics-informed digital twin (DT) framework combined with an uncertainty-aware, expert-weighted stacked ensemble for multimodal forecasting of Core Body Temperature (CBT) in dairy cattle. Using the high-frequency, heterogeneous MmCows dataset, the DT integrates an ordinary differential equation (ODE)-based thermoregulation model that simulates metabolic heat production and dissipation, a Gaussian process for capturing cow-specific deviations, a Kalman filter for aligning predictions with real-time sensor data, and a behavioral Markov chain that models activity-state transitions under varying environmental conditions. The DT outputs key physiological indicators, such as predicted CBT, heat stress probability, and behavioral state distributions are fused with raw sensor data and enriched through multi-scale temporal analysis and cross-modal feature engineering to form a comprehensive feature set. The predictive methodology is designed in a three-stage stacked ensemble, where stage 1 trains modality-specific LightGBM 'expert' models on distinct feature groups, stage 2 collects their predictions as meta-features, and at stage 3 Optuna-tuned LightGBM meta-model yields the final CBT forecast. Predictive uncertainty is quantified via bootstrapping and validated using Prediction Interval Coverage Probability (PICP). Ablation analysis confirms that incorporating DT-derived features and multimodal fusion substantially enhances performance. The proposed framework achieves a cross-validated R2 of 0.783, F1 score of 84.25% and PICP of 92.38% for 2-hour ahead forecasting, providing a robust, uncertainty-aware, and physically principled system for early heat stress detection and precision livestock management.

Arefin Ittesafun Abian, Debopom Sutradhar, Md Rafi Ur Rashid et al.

Insect classification is important for agricultural management and ecological research, as it directly affects crop health and production. However, this task remains challenging due to the complex characteristics of insects, class imbalance, and large-scale datasets. To address these issues, we propose BioAutoML-NAS, the first BioAutoML model using multimodal data, including images, and metadata, which applies neural architecture search (NAS) for images to automatically learn the best operations for each connection within each cell. Multiple cells are stacked to form the full network, each extracting detailed image feature representations. A multimodal fusion module combines image embeddings with metadata, allowing the model to use both visual and categorical biological information to classify insects. An alternating bi-level optimization training strategy jointly updates network weights and architecture parameters, while zero operations remove less important connections, producing sparse, efficient, and high-performing architectures. Extensive evaluation on the BIOSCAN-5M dataset demonstrates that BioAutoML-NAS achieves 96.81% accuracy, 97.46% precision, 96.81% recall, and a 97.05% F1 score, outperforming state-of-the-art transfer learning, transformer, AutoML, and NAS methods by approximately 16%, 10%, and 8% respectively. Further validation on the Insects-1M dataset obtains 93.25% accuracy, 93.71% precision, 92.74% recall, and a 93.22% F1 score. These results demonstrate that BioAutoML-NAS provides accurate, confident insect classification that supports modern sustainable farming.

Debopom Sutradhar, Arefin Ittesafun Abian, Mohaimenul Azam Khan Raiaan et al.

Accurate land cover classification from satellite imagery is crucial in environmental monitoring and sustainable resource management. However, it remains challenging due to the complexity of natural landscapes, the visual similarity between classes, and the significant class imbalance in the available datasets. To address these issues, we propose a dual encoder architecture that independently extracts modality-specific features from optical and Synthetic Aperture Radar (SAR) imagery, which are then fused using a cross-modality attention-fusion module named Cross-modality Land cover segmentation with Attention and Imbalance-aware Reasoning-Enhanced Explanations (CLAIRE). This fusion mechanism highlights complementary spatial and textural features, enabling the network to better capture detailed and diverse land cover patterns. We incorporate a hybrid loss function that utilizes Weighted Focal Loss and Tversky Loss named RIFT (Rare-Instance Focal-Tversky) to address class imbalance and improve segmentation performance across underrepresented categories. Our model achieves competitive performance across multiple benchmarks: a mean Intersection over Union (mIoU) of 56.02% and Overall Accuracy (OA) of 84.56% on the WHU-OPT-SAR dataset; strong generalization with a mIoU of 59.89% and OA of 73.92% on the OpenEarthMap-SAR dataset; and remarkable robustness under cloud-obstructed conditions, achieving an mIoU of 86.86% and OA of 94.58% on the PIE-RGB-SAR dataset. Additionally, we introduce a metric-driven reasoning module generated by a Small Language Model (Phi-3), which generates expert-level, sample-specific justifications for model predictions, thereby enhancing transparency and interpretability.

Arefin Ittesafun Abian, Ripon Kumar Debnath, Md. Abdur Rahman et al.

Accurate liver and tumor segmentation on abdominal CT images is critical for reliable diagnosis and treatment planning, but remains challenging due to complex anatomical structures, variability in tumor appearance, and limited annotated data. To address these issues, we introduce Hyperbolic-convolutions Adaptive-temporal-attention with Neural-representation and Synaptic-plasticity Network (HANS-Net), a novel segmentation framework that synergistically combines hyperbolic convolutions for hierarchical geometric representation, a wavelet-inspired decomposition module for multi-scale texture learning, a biologically motivated synaptic plasticity mechanism for adaptive feature enhancement, and an implicit neural representation branch to model fine-grained and continuous anatomical boundaries. Additionally, we incorporate uncertainty-aware Monte Carlo dropout to quantify prediction confidence and lightweight temporal attention to improve inter-slice consistency without sacrificing efficiency. Extensive evaluations of the LiTS dataset demonstrate that HANS-Net achieves a mean Dice score of 93.26%, an IoU of 88.09%, an average symmetric surface distance (ASSD) of 0.72 mm, and a volume overlap error (VOE) of 11.91%. Furthermore, cross-dataset validation on the AMOS 2022 dataset obtains an average Dice of 85.09%, IoU of 76.66%, ASSD of 19.49 mm, and VOE of 23.34%, indicating strong generalization across different datasets. These results confirm the effectiveness and robustness of HANS-Net in providing anatomically consistent, accurate, and confident liver and tumor segmentation.