Mohaimenul Azam Khan Raiaan

Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan, Arefin Ittesafun Abian et al.

Gliomas are among the most aggressive cancers, characterized by high mortality rates and complex diagnostic processes. Existing studies on glioma diagnosis and classification often describe issues such as high variability in imaging data, inadequate optimization of computational resources, and inefficient segmentation and classification of gliomas. To address these challenges, we propose novel techniques utilizing multi-parametric MRI data to enhance tumor segmentation and classification efficiency. Our work introduces the first-ever radiomics-enhanced fused residual multiparametric 3D network (ReFRM3D) for brain tumor characterization, which is based on a 3D U-Net architecture and features multi-scale feature fusion, hybrid upsampling, and an extended residual skip mechanism. Additionally, we propose a multi-feature tumor marker-based classifier that leverages radiomic features extracted from the segmented regions. Experimental results demonstrate significant improvements in segmentation performance across the BraTS2019, BraTS2020, and BraTS2021 datasets, achieving high Dice Similarity Coefficients (DSC) of 94.04%, 92.68%, and 93.64% for whole tumor (WT), enhancing tumor (ET), and tumor core (TC) respectively in BraTS2019; 94.09%, 92.91%, and 93.84% in BraTS2020; and 93.70%, 90.36%, and 92.13% in BraTS2021.

Md. Adnanul Islam, Wasimul Karim, Md Mahbub Alam et al.

Accurate weight estimation of commercial and industrial waste is important for efficient operations, yet image-based estimation remains difficult because similar-looking objects may have different densities, and the visible size changes with camera distance. Addressing this problem, we propose Multimodal Weight Predictor (MWP) framework that estimates waste weight by combining RGB images with physics-informed metadata, including object dimensions, camera distance, and camera height. We also introduce Waste-Weight-10K, a real-world dataset containing 10,421 synchronized image-metadata collected from logistics and recycling sites. The dataset covers 11 waste categories and a wide weight range from 3.5 to 3,450 kg. Our model uses a Vision Transformer for visual features and a dedicated metadata encoder for geometric and category information, combining them with Stacked Mutual Attention Fusion that allows visual and physical cues guide each other. This helps the model manage perspective effects and link objects to material properties. To ensure stable performance across the wide weight range, we train the model using Mean Squared Logarithmic Error. On the test set, the proposed method achieves 88.06 kg Mean Absolute Error (MAE), 6.39% Mean Absolute Percentage Error (MAPE), and an R2 coefficient of 0.9548. The model shows strong accuracy for light objects in the 0-100 kg range with 2.38 kg MAE and 3.1% MAPE, maintaining reliable performance for heavy waste in the 1000-2000 kg range with 11.1% MAPE. Finally, we incorporate a physically grounded explanation module using Shapley Additive Explanations (SHAP) and a large language model to provide clear, human-readable explanations for each prediction.

Musarrat Zeba, Abdullah Al Mamun, Kishoar Jahan Tithee et al.

In healthcare, it is essential for any LLM-generated output to be reliable and accurate, particularly in cases involving decision-making and patient safety. However, the outputs are often unreliable in such critical areas due to the risk of hallucinated outputs from the LLMs. To address this issue, we propose a fact-checking module that operates independently of any LLM, along with a domain-specific summarization model designed to minimize hallucination rates. Our model is fine-tuned using Low-Rank Adaptation (LoRa) on the MIMIC III dataset and is paired with the fact-checking module, which uses numerical tests for correctness and logical checks at a granular level through discrete logic in natural language processing (NLP) to validate facts against electronic health records (EHRs). We trained the LLM model on the full MIMIC-III dataset. For evaluation of the fact-checking module, we sampled 104 summaries, extracted them into 3,786 propositions, and used these as facts. The fact-checking module achieves a precision of 0.8904, a recall of 0.8234, and an F1-score of 0.8556. Additionally, the LLM summary model achieves a ROUGE-1 score of 0.5797 and a BERTScore of 0.9120 for summary quality.

Debopom Sutradhar, Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan et al.

Domain adaptation (DA) addresses the challenge of transferring knowledge from a source domain to a target domain where image data distributions may differ. Existing DA methods often require access to source domain data, adversarial training, or complex pseudo-labeling techniques, which are computationally expensive. To address these challenges, this paper introduces a novel source-free domain adaptation method. It is the first approach to use multiview augmentation and latent space consistency techniques to learn domain-invariant features directly from the target domain. Our method eliminates the need for source-target alignment or pseudo-label refinement by learning transferable representations solely from the target domain by enforcing consistency between multiple augmented views in the latent space. Additionally, the method ensures consistency in the learned features by generating multiple augmented views of target domain data and minimizing the distance between their feature representations in the latent space. We also introduce a ConvNeXt-based encoder and design a loss function that combines classification and consistency objectives to drive effective adaptation directly from the target domain. The proposed model achieves an average classification accuracy of 90. 72\%, 84\%, and 97. 12\% in Office-31, Office-Home and Office-Caltech datasets, respectively. Further evaluations confirm that our study improves existing methods by an average classification accuracy increment of +1.23\%, +7.26\%, and +1.77\% on the respective datasets.

Riasad Alvi, Sayeem Been Zaman, Wasimul Karim et al.

Generative artificial intelligence (GenAI) has become a transformative approach in bioinformatics that often enables advancements in genomics, proteomics, transcriptomics, structural biology, and drug discovery. To systematically identify and evaluate these growing developments, this review proposed six research questions (RQs), according to the preferred reporting items for systematic reviews and meta-analysis methods. The objective is to evaluate impactful GenAI strategies in methodological advancement, predictive performance, and specialization, and to identify promising approaches for advanced modeling, data-intensive discovery, and integrative biological analysis. RQ1 highlights diverse applications across multiple bioinformatics subfields (sequence analysis, molecular design, and integrative data modeling), which demonstrate superior performance over traditional methods through pattern recognition and output generation. RQ2 reveals that adapted specialized model architectures outperformed general-purpose models, an advantage attributed to targeted pretraining and context-aware strategies. RQ3 identifies significant benefits in the bioinformatics domains, focusing on molecular analysis and data integration, which improves accuracy and reduces errors in complex analysis. RQ4 indicates improvements in structural modeling, functional prediction, and synthetic data generation, validated by established benchmarks. RQ5 suggests the main constraints, such as the lack of scalability and biases in data that impact generalizability, and proposes future directions focused on robust evaluation and biologically grounded modeling. RQ6 examines that molecular datasets (such as UniProtKB and ProteinNet12), cellular datasets (such as CELLxGENE and GTEx) and textual resources (such as PubMedQA and OMIM) broadly support the training and generalization of GenAI models.

Sadia Sultana Chowa, Riasad Alvi, Subhey Sadi Rahman et al.

The pursuit of human-level artificial intelligence (AI) has significantly advanced the development of autonomous agents and Large Language Models (LLMs). LLMs are now widely utilized as decision-making agents for their ability to interpret instructions, manage sequential tasks, and adapt through feedback. This review examines recent developments in employing LLMs as autonomous agents and tool users and comprises seven research questions. We only used the papers published between 2023 and 2025 in conferences of the A* and A rank and Q1 journals. A structured analysis of the LLM agents' architectural design principles, dividing their applications into single-agent and multi-agent systems, and strategies for integrating external tools is presented. In addition, the cognitive mechanisms of LLM, including reasoning, planning, and memory, and the impact of prompting methods and fine-tuning procedures on agent performance are also investigated. Furthermore, we evaluated current benchmarks and assessment protocols and have provided an analysis of 68 publicly available datasets to assess the performance of LLM-based agents in various tasks. In conducting this review, we have identified critical findings on verifiable reasoning of LLMs, the capacity for self-improvement, and the personalization of LLM-based agents. Finally, we have discussed ten future research directions to overcome these gaps.

Subhey Sadi Rahman, Md. Adnanul Islam, Md. Mahbub Alam et al.

Large Language Models (LLMs) are trained on vast and diverse internet corpora that often include inaccurate or misleading content. Consequently, LLMs can generate misinformation, making robust fact-checking essential. This review systematically analyzes how LLM-generated content is evaluated for factual accuracy by exploring key challenges such as hallucinations, dataset limitations, and the reliability of evaluation metrics. The review emphasizes the need for strong fact-checking frameworks that integrate advanced prompting strategies, domain-specific fine-tuning, and retrieval-augmented generation (RAG) methods. It proposes five research questions that guide the analysis of the recent literature from 2020 to 2025, focusing on evaluation methods and mitigation techniques. Instruction tuning, multi-agent reasoning, and RAG frameworks for external knowledge access are also reviewed. The key findings demonstrate the limitations of current metrics, the importance of validated external evidence, and the improvement of factual consistency through domain-specific customization. The review underscores the importance of building more accurate, understandable, and context-aware fact-checking. These insights contribute to the advancement of research toward more trustworthy models.

Riasad Alvi, Mohaimenul Azam Khan Raiaan, Sadia Sultana Chowa et al.

Precision livestock farming requires accurate and timely heat stress prediction to ensure animal welfare and optimize farm management. This study presents a physics-informed digital twin (DT) framework combined with an uncertainty-aware, expert-weighted stacked ensemble for multimodal forecasting of Core Body Temperature (CBT) in dairy cattle. Using the high-frequency, heterogeneous MmCows dataset, the DT integrates an ordinary differential equation (ODE)-based thermoregulation model that simulates metabolic heat production and dissipation, a Gaussian process for capturing cow-specific deviations, a Kalman filter for aligning predictions with real-time sensor data, and a behavioral Markov chain that models activity-state transitions under varying environmental conditions. The DT outputs key physiological indicators, such as predicted CBT, heat stress probability, and behavioral state distributions are fused with raw sensor data and enriched through multi-scale temporal analysis and cross-modal feature engineering to form a comprehensive feature set. The predictive methodology is designed in a three-stage stacked ensemble, where stage 1 trains modality-specific LightGBM 'expert' models on distinct feature groups, stage 2 collects their predictions as meta-features, and at stage 3 Optuna-tuned LightGBM meta-model yields the final CBT forecast. Predictive uncertainty is quantified via bootstrapping and validated using Prediction Interval Coverage Probability (PICP). Ablation analysis confirms that incorporating DT-derived features and multimodal fusion substantially enhances performance. The proposed framework achieves a cross-validated R2 of 0.783, F1 score of 84.25% and PICP of 92.38% for 2-hour ahead forecasting, providing a robust, uncertainty-aware, and physically principled system for early heat stress detection and precision livestock management.

Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan, Sami Azam et al.

Knowledge distillation (KD) has traditionally relied on a static teacher-student framework, where a large, well-trained teacher transfers knowledge to a single student model. However, these approaches often suffer from knowledge degradation, inefficient supervision, and reliance on either a very strong teacher model or large labeled datasets. To address these, we present the first-ever Weakly-supervised Chain-based KD network (WeCKD) that redefines knowledge transfer through a structured sequence of interconnected models. Unlike conventional KD, it forms a progressive distillation chain, where each model not only learns from its predecessor but also refines the knowledge before passing it forward. This structured knowledge transfer further enhances feature learning and addresses the limitations of one-step KD. Each model in the chain is trained on only a fraction of the dataset and shows that effective learning can be achieved with minimal supervision. Extensive evaluation on six imaging datasets across otoscopic, microscopic, and magnetic resonance imaging modalities shows that it generalizes and outperforms existing methods. Furthermore, the proposed distillation chain resulted in cumulative accuracy gains of up to +23% over a single backbone trained on the same limited data, which highlights its potential for real-world adoption.

Debopom Sutradhar, Arefin Ittesafun Abian, Mohaimenul Azam Khan Raiaan et al.

Accurate land cover classification from satellite imagery is crucial in environmental monitoring and sustainable resource management. However, it remains challenging due to the complexity of natural landscapes, the visual similarity between classes, and the significant class imbalance in the available datasets. To address these issues, we propose a dual encoder architecture that independently extracts modality-specific features from optical and Synthetic Aperture Radar (SAR) imagery, which are then fused using a cross-modality attention-fusion module named Cross-modality Land cover segmentation with Attention and Imbalance-aware Reasoning-Enhanced Explanations (CLAIRE). This fusion mechanism highlights complementary spatial and textural features, enabling the network to better capture detailed and diverse land cover patterns. We incorporate a hybrid loss function that utilizes Weighted Focal Loss and Tversky Loss named RIFT (Rare-Instance Focal-Tversky) to address class imbalance and improve segmentation performance across underrepresented categories. Our model achieves competitive performance across multiple benchmarks: a mean Intersection over Union (mIoU) of 56.02% and Overall Accuracy (OA) of 84.56% on the WHU-OPT-SAR dataset; strong generalization with a mIoU of 59.89% and OA of 73.92% on the OpenEarthMap-SAR dataset; and remarkable robustness under cloud-obstructed conditions, achieving an mIoU of 86.86% and OA of 94.58% on the PIE-RGB-SAR dataset. Additionally, we introduce a metric-driven reasoning module generated by a Small Language Model (Phi-3), which generates expert-level, sample-specific justifications for model predictions, thereby enhancing transparency and interpretability.

Md. Abdur Rahman, Mohaimenul Azam Khan Raiaan, Tamanna Shermin et al.

Musculoskeletal disorders pose significant risks to athletes, and assessing risk early is important for prevention. However, most existing methods are designed for controlled settings and fail to reliably assess risk in complex environments due to their reliance on a single type of data. This research introduces ViSK-GAT (Visual-Skeletal Geometric Attention Transformer), a novel multimodal deep learning framework that classifies musculoskeletal risk using both visual and skeletal coordinate-based features. A custom multimodal dataset (MusDis-Sports) was created by combining images and skeletal coordinates, with each sample labeled into eight risk categories based on the Rapid Entire Body Assessment (REBA) system. ViSK-GAT integrates two innovative modules: the Fine-Grained Attention Module (FGAM), which refines inter-modal features via cross-attention between visual and skeletal inputs, and the Multimodal Geometric Correspondence Module (MGCM), which enhances cross-modal alignment between image features and coordinates. The model achieved robust performance, with all key metrics exceeding 93%. Regression results also indicated a low RMSE of 0.1205 and MAE of 0.0156. ViSK-GAT consistently outperformed nine popular transfer learning backbones and showed its potential to advance AI-driven musculoskeletal risk assessment and enable early, impactful interventions in sports.

Debopom Sutradhar, Ripon Kumar Debnath, Mohaimenul Azam Khan Raiaan et al.

Low-dose computed tomography (LDCT) is critical for minimizing radiation exposure, but it often leads to increased noise and reduced image quality. Traditional denoising methods, such as iterative optimization or supervised learning, often fail to preserve image quality. To address these challenges, we introduce PPORLD-EDNetLDCT, a reinforcement learning-based (RL) approach with Encoder-Decoder for LDCT. Our method utilizes a dynamic RL-based approach in which an advanced posterior policy optimization (PPO) algorithm is used to optimize denoising policies in real time, based on image quality feedback, trained via a custom gym environment. The experimental results on the low dose CT image and projection dataset demonstrate that the proposed PPORLD-EDNetLDCT model outperforms traditional denoising techniques and other DL-based methods, achieving a peak signal-to-noise ratio of 41.87, a structural similarity index measure of 0.9814 and a root mean squared error of 0.00236. Moreover, in NIH-AAPM-Mayo Clinic Low Dose CT Challenge dataset our method achieved a PSNR of 41.52, SSIM of 0.9723 and RMSE of 0.0051. Furthermore, we validated the quality of denoising using a classification task in the COVID-19 LDCT dataset, where the images processed by our method improved the classification accuracy to 94%, achieving 4% higher accuracy compared to denoising without RL-based denoising.

Arefin Ittesafun Abian, Ripon Kumar Debnath, Md. Abdur Rahman et al.

Accurate liver and tumor segmentation on abdominal CT images is critical for reliable diagnosis and treatment planning, but remains challenging due to complex anatomical structures, variability in tumor appearance, and limited annotated data. To address these issues, we introduce Hyperbolic-convolutions Adaptive-temporal-attention with Neural-representation and Synaptic-plasticity Network (HANS-Net), a novel segmentation framework that synergistically combines hyperbolic convolutions for hierarchical geometric representation, a wavelet-inspired decomposition module for multi-scale texture learning, a biologically motivated synaptic plasticity mechanism for adaptive feature enhancement, and an implicit neural representation branch to model fine-grained and continuous anatomical boundaries. Additionally, we incorporate uncertainty-aware Monte Carlo dropout to quantify prediction confidence and lightweight temporal attention to improve inter-slice consistency without sacrificing efficiency. Extensive evaluations of the LiTS dataset demonstrate that HANS-Net achieves a mean Dice score of 93.26%, an IoU of 88.09%, an average symmetric surface distance (ASSD) of 0.72 mm, and a volume overlap error (VOE) of 11.91%. Furthermore, cross-dataset validation on the AMOS 2022 dataset obtains an average Dice of 85.09%, IoU of 76.66%, ASSD of 19.49 mm, and VOE of 23.34%, indicating strong generalization across different datasets. These results confirm the effectiveness and robustness of HANS-Net in providing anatomically consistent, accurate, and confident liver and tumor segmentation.