John Doyle

Anthony Zador, Jean-Marc Fellous, Terrence Sejnowski et al. · uw

Neuroscience and Artificial Intelligence (AI) have made impressive progress in recent years but remain only loosely interconnected. Based on a workshop convened by the National Science Foundation in August 2025, we identify three fundamental capability gaps in current AI: the inability to interact with the physical world, inadequate learning that produces brittle systems, and unsustainable energy and data inefficiency. We describe the neuroscience principles that address each: co-design of body and controller, prediction through interaction, multi-scale learning with neuromodulatory control, hierarchical distributed architectures, and sparse event-driven computation. We present a research roadmap organized around these principles at near, mid, and long-term horizons. We argue that realizing this program requires a new generation of researchers trained across the boundary between neuroscience and engineering, and describe the institutional conditions: interdisciplinary training, hardware access, community standards, and ethics, needed to support them. We conclude that NeuroAI, neuroscience-informed artificial intelligence, has the potential to overcome limitations of current AI while deepening our understanding of biological neural computation.

Dimitar Ho, John Doyle

We present a simple model-free control algorithm that is able to robustly learn and stabilize an unknown discrete-time linear system with full control and state feedback subject to arbitrary bounded disturbance and noise sequences. The controller does not require any prior knowledge of the system dynamics, disturbances, or noise, yet it can guarantee robust stability and provides asymptotic and worst-case bounds on the state and input trajectories. To the best of our knowledge, this is the first model-free algorithm that comes with such robust stability guarantees without the need to make any prior assumptions about the system. We would like to highlight the new convex geometry-based approach taken towards robust stability analysis which served as a key enabler in our results. We will conclude with simulation results that show that despite the generality and simplicity, the controller demonstrates good closed-loop performance.