Ahmad Enhesari

Rassa Ghavami Modegh, Mehrab Hamidi, Saeed Masoudian et al.

COVID-19 is a virus with high transmission rate that demands rapid identification of the infected patients to reduce the spread of the disease. The current gold-standard test, Reverse-Transcription Polymerase Chain Reaction (RT-PCR), has a high rate of false negatives. Diagnosing from CT-scan images as a more accurate alternative has the challenge of distinguishing COVID-19 from other pneumonia diseases. Artificial intelligence can help radiologists and physicians to accelerate the process of diagnosis, increase its accuracy, and measure the severity of the disease. We designed a new interpretable deep neural network to distinguish healthy people, patients with COVID-19, and patients with other pneumonia diseases from axial lung CT-scan images. Our model also detects the infected areas and calculates the percentage of the infected lung volume. We first preprocessed the images to eliminate the batch effects of different devices, and then adopted a weakly supervised method to train the model without having any tags for the infected parts. We trained and evaluated the model on a large dataset of 3359 samples from 6 different medical centers. The model reached sensitivities of 97.75% and 98.15%, and specificities of 87% and 81.03% in separating healthy people from the diseased and COVID-19 from other diseases, respectively. It also demonstrated similar performance for 1435 samples from 6 different medical centers which proves its generalizability. The performance of the model on a large diverse dataset, its generalizability, and interpretability makes it suitable to be used as a reliable diagnostic system.

Mitra Montazeri, Mahdieh Soleymani Baghshah, Ahmad Enhesari

Background: Lung cancer was known as primary cancers and the survival rate of cancer is about 15%. Early detection of lung cancer is the leading factor in survival rate. All symptoms (features) of lung cancer do not appear until the cancer spreads to other areas. It needs an accurate early detection of lung cancer, for increasing the survival rate. For accurate detection, it need characterizes efficient features and delete redundancy features among all features. Feature selection is the problem of selecting informative features among all features. Materials and Methods: Lung cancer database consist of 32 patient records with 57 features. This database collected by Hong and Youngand indexed in the University of California Irvine repository. Experimental contents include the extracted from the clinical data and X-ray data, etc. The data described 3 types of pathological lung cancers and all features are taking an integer value 0-3. In our study, new method is proposed for identify efficient features of lung cancer. It is based on Hyper-Heuristic. Results: We obtained an accuracy of 80.63% using reduced 11 feature set. The proposed method compare to the accuracy of 5 machine learning feature selections. The accuracy of these 5 methods are 60.94, 57.81, 68.75, 60.94 and 68.75. Conclusions: The proposed method has better performance with the highest level of accuracy. Therefore, the proposed model is recommended for identifying an efficient symptom of Disease. These finding are very important in health research, particularly in allocation of medical resources for patients who predicted as high-risks