Ruipeng Guo

Joseph L. Greene, Suet YIng Chan, Qilin Deng et al.

Extended depth of field microscopy encodes axial information into a single acquisition through engineered point spread functions, but conventional and deep optics approaches are subject to degradation in scattering tissue. We introduce DeepFilters, a scattering-aware deep optics framework that jointly optimizes a parameterized pupil filter and a digital-filter-based reconstruction network through a calibrated differentiable forward model to achieve broad generalization without retraining. Incorporating empirical scattering kernels, physics-guided regularization, and a hybrid genetic-gradient initialization strategy, DeepFilters extends the PSF from 16 micron to >400 micron in clear media and enables signal recovery beyond 120 micron deep in biological tissues, validated across fixed brain slices and sea urchin embryos.

Ruipeng Guo, Soren Nelson, Rajesh Menon

We experimentally demonstrate a camera whose primary optic is a cannula (diameter=0.22mm and length=12.5mm) that acts a lightpipe transporting light intensity from an object plane (35cm away) to its opposite end. Deep neural networks (DNNs) are used to reconstruct color and grayscale images with field of view of 180 and angular resolution of ~0.40. When trained on images with depth information, the DNN can create depth maps. Finally, we show DNN-based classification of the EMNIST dataset without and with image reconstructions. The former could be useful for imaging with enhanced privacy.