Yunpeng Zhao

Yefeng Wang, Yunpeng Zhao, Jiang Bian et al.

Objective: The objective of this study is to develop a deep learning pipeline to detect signals on dietary supplement-related adverse events (DS AEs) from Twitter. Material and Methods: We obtained 247,807 tweets ranging from 2012 to 2018 that mentioned both DS and AE. We annotated biomedical entities and relations on 2,000 randomly selected tweets. For the concept extraction task, we compared the performance of traditional word embeddings with SVM, CRF and LSTM-CRF classifiers to BERT models. For the relation extraction task, we compared GloVe vectors with CNN classifiers to BERT models. We chose the best performing models in each task to assemble an end-to-end deep learning pipeline to detect DS AE signals and compared the results to the known DS AEs from a DS knowledge base (i.e., iDISK). Results: In both tasks, the BERT-based models outperformed traditional word embeddings. The best performing concept extraction model is the BioBERT model that can identify supplement, symptom, and body organ entities with F1-scores of 0.8646, 0.8497, and 0.7104, respectively. The best performing relation extraction model is the BERT model that can identify purpose and AE relations with F1-scores of 0.8335 and 0.7538, respectively. The end-to-end pipeline was able to extract DS indication and DS AEs with an F1-score of 0.7459 and 0,7414, respectively. Comparing to the iDISK, we could find both known and novel DS-AEs. Conclusion: We have demonstrated the feasibility of detecting DS AE signals from Twitter with a BioBERT-based deep learning pipeline.

Yunpeng Zhao, Mattia Prosperi, Tianchen Lyu et al.

Social media, especially Twitter, is being increasingly used for research with predictive analytics. In social media studies, natural language processing (NLP) techniques are used in conjunction with expert-based, manual and qualitative analyses. However, social media data are unstructured and must undergo complex manipulation for research use. The manual annotation is the most resource and time-consuming process that multiple expert raters have to reach consensus on every item, but is essential to create gold-standard datasets for training NLP-based machine learning classifiers. To reduce the burden of the manual annotation, yet maintaining its reliability, we devised a crowdsourcing pipeline combined with active learning strategies. We demonstrated its effectiveness through a case study that identifies job loss events from individual tweets. We used Amazon Mechanical Turk platform to recruit annotators from the Internet and designed a number of quality control measures to assure annotation accuracy. We evaluated 4 different active learning strategies (i.e., least confident, entropy, vote entropy, and Kullback-Leibler divergence). The active learning strategies aim at reducing the number of tweets needed to reach a desired performance of automated classification. Results show that crowdsourcing is useful to create high-quality annotations and active learning helps in reducing the number of required tweets, although there was no substantial difference among the strategies tested.

Francois Modave, Yunpeng Zhao, Janice Krieger et al.

Among American women, the rate of breast cancer is only second to lung cancer. An estimated 12.4% women will develop breast cancer over the course of their lifetime. The widespread use of social media across the socio-economic spectrum offers unparalleled ways to facilitate information sharing, in particular as it pertains to health. Social media is also used by many healthcare stakeholders, ranging from government agencies to healthcare industry, to disseminate health information and to engage patients. The purpose of this study is to investigate people's perceptions and attitudes relate to breast cancer, especially those that are related to physical activities, on Twitter. To achieve this, we first identified and collected tweets related to breast cancer; and then used topic modeling and sentiment analysis techniques to understanding discussion themes and quantify Twitter users' perceptions and emotions w.r.t breast cancer to answer 5 research questions.

Chengan Du, Yunpeng Zhao, Feng Wang

Graph-based semi-supervised learning is one of the most popular methods in machine learning. Some of its theoretical properties such as bounds for the generalization error and the convergence of the graph Laplacian regularizer have been studied in computer science and statistics literatures. However, a fundamental statistical property, the consistency of the estimator from this method has not been proved. In this article, we study the consistency problem under a non-parametric framework. We prove the consistency of graph-based learning in the case that the estimated scores are enforced to be equal to the observed responses for the labeled data. The sample sizes of both labeled and unlabeled data are allowed to grow in this result. When the estimated scores are not required to be equal to the observed responses, a tuning parameter is used to balance the loss function and the graph Laplacian regularizer. We give a counterexample demonstrating that the estimator for this case can be inconsistent. The theoretical findings are supported by numerical studies.