Ivo D. Dinov

h-index55
2papers
10,755citations

2 Papers

7.2MATH-PHJul 8
Kime-Representation Formulations of Three Open Problems in the Foundations of Classical Mechanics: Uncertainty, Invariant Entropy, and Directional Degrees of Freedom

Ivo D. Dinov

We give mathematically self-contained formulations, in the complex-time (kime) representation, of three open problems from the foundations of classical mechanics: (I) the extension of the classical entropic uncertainty principle to non-canonical variables and to multiple degrees of freedom; (II) the characterization of coordinate-invariant measures and entropies, i.e., the question of why continuous physical quantities must be paired for an invariant entropy to exist; and (III) the construction of a classical relativistic directional degree of freedom (a classical analogue of a spin-1/2 system). Throughout, the kime phase is interpreted {statistically as a latent circular random variable whose law Φmodels the intrinsic trial-to-trial variability of repeated, identically controlled experiments indexed by the kime magnitude. The mathematical bridge is an exact symplectic identification of the kime cone with the action-angle chart of a one-degree-of-freedom phase space, under which the kime measure is the Liouville measure and the phase law becomes the angular conditional of a Liouville density. Specifically, we (i) prove a sharp entropic uncertainty relation on the kime cylinder whose extremal family is von Mises x Gaussian, together with a sharp circular Fisher-information inequality saturated exactly by von Mises laws; (ii) prove an exact non-canonical uncertainty relation in which the correction term is the geometric mean of the Poisson bracket, clarifying the conjectured role of the expected bracket; (iii) prove aggregate multi-degree-of-freedom bounds via the Williamson normal form and Fischer's inequality, and isolate the per-degree-of-freedom refinement as a precise open problem of symplectic Schur-Horn type; (iv) prove that diffusion of the kime phase produces monotone entropy growth with the equipartitioned (Haar-uniform) phase law.

3.8MLFeb 9, 2022
Precision Radiotherapy via Information Integration of Expert Human Knowledge and AI Recommendation to Optimize Clinical Decision Making

Wenbo Sun, Dipesh Niraula, Issam El Naqa et al.

In the precision medicine era, there is a growing need for precision radiotherapy where the planned radiation dose needs to be optimally determined by considering a myriad of patient-specific information in order to ensure treatment efficacy. Existing artificial-intelligence (AI) methods can recommend radiation dose prescriptions within the scope of this available information. However, treating physicians may not fully entrust the AI's recommended prescriptions due to known limitations or when the AI recommendation may go beyond physicians' current knowledge. This paper lays out a systematic method to integrate expert human knowledge with AI recommendations for optimizing clinical decision making. Towards this goal, Gaussian process (GP) models are integrated with deep neural networks (DNNs) to quantify the uncertainty of the treatment outcomes given by physicians and AI recommendations, respectively, which are further used as a guideline to educate clinical physicians and improve AI models performance. The proposed method is demonstrated in a comprehensive dataset where patient-specific information and treatment outcomes are prospectively collected during radiotherapy of $67$ non-small cell lung cancer patients and retrospectively analyzed.