Jacinto C. Nascimento

Chihcheng Hsieh, Isabel Blanco Nobre, Sandra Costa Sousa et al.

This study investigates the effects of including patients' clinical information on the performance of deep learning (DL) classifiers for disease location in chest X-ray images. Although current classifiers achieve high performance using chest X-ray images alone, our interviews with radiologists indicate that clinical data is highly informative and essential for interpreting images and making proper diagnoses. In this work, we propose a novel architecture consisting of two fusion methods that enable the model to simultaneously process patients' clinical data (structured data) and chest X-rays (image data). Since these data modalities are in different dimensional spaces, we propose a spatial arrangement strategy, spatialization, to facilitate the multimodal learning process in a Mask R-CNN model. We performed an extensive experimental evaluation using MIMIC-Eye, a dataset comprising modalities: MIMIC-CXR (chest X-ray images), MIMIC IV-ED (patients' clinical data), and REFLACX (annotations of disease locations in chest X-rays). Results show that incorporating patients' clinical data in a DL model together with the proposed fusion methods improves the disease localization in chest X-rays by 12\% in terms of Average Precision compared to a standard Mask R-CNN using only chest X-rays. Further ablation studies also emphasize the importance of multimodal DL architectures and the incorporation of patients' clinical data in disease localization. The architecture proposed in this work is publicly available to promote the scientific reproducibility of our study (https://github.com/ChihchengHsieh/multimodal-abnormalities-detection)

Renato Hermoza, Gabriel Maicas, Jacinto C. Nascimento et al.

Survival time prediction from medical images is important for treatment planning, where accurate estimations can improve healthcare quality. One issue affecting the training of survival models is censored data. Most of the current survival prediction approaches are based on Cox models that can deal with censored data, but their application scope is limited because they output a hazard function instead of a survival time. On the other hand, methods that predict survival time usually ignore censored data, resulting in an under-utilization of the training set. In this work, we propose a new training method that predicts survival time using all censored and uncensored data. We propose to treat censored data as samples with a lower-bound time to death and estimate pseudo labels to semi-supervise a censor-aware survival time regressor. We evaluate our method on pathology and x-ray images from the TCGA-GM and NLST datasets. Our results establish the state-of-the-art survival prediction accuracy on both datasets.

José Celestino, Manuel Marques, Jacinto C. Nascimento et al.

Head orientation is a challenging Computer Vision problem that has been extensively researched having a wide variety of applications. However, current state-of-the-art systems still underperform in the presence of occlusions and are unreliable for many task applications in such scenarios. This work proposes a novel deep learning approach for the problem of head pose estimation under occlusions. The strategy is based on latent space regression as a fundamental key to better structure the problem for occluded scenarios. Our model surpasses several state-of-the-art methodologies for occluded HPE, and achieves similar accuracy for non-occluded scenarios. We demonstrate the usefulness of the proposed approach with: (i) two synthetically occluded versions of the BIWI and AFLW2000 datasets, (ii) real-life occlusions of the Pandora dataset, and (iii) a real-life application to human-robot interaction scenarios where face occlusions often occur. Specifically, the autonomous feeding from a robotic arm.

Chihcheng Hsieh, Catarina Moreira, Isabel Blanco Nobre et al.

X-ray images are vital in medical diagnostics, but their effectiveness is limited without clinical context. Radiologists often find chest X-rays insufficient for diagnosing underlying diseases, necessitating the integration of structured clinical features with radiology reports. To address this, we introduce DALL-M, a novel framework that enhances clinical datasets by generating contextual synthetic data. DALL-M augments structured patient data, including vital signs (e.g., heart rate, oxygen saturation), radiology findings (e.g., lesion presence), and demographic factors. It integrates this tabular data with contextual knowledge extracted from radiology reports and domain-specific resources (e.g., Radiopaedia, Wikipedia), ensuring clinical consistency and reliability. DALL-M follows a three-phase process: (i) clinical context storage, (ii) expert query generation, and (iii) context-aware feature augmentation. Using large language models (LLMs), it generates both contextual synthetic values for existing clinical features and entirely new, clinically relevant features. Applied to 799 cases from the MIMIC-IV dataset, DALL-M expanded the original 9 clinical features to 91. Empirical validation with machine learning models (including Decision Trees, Random Forests, XGBoost, and TabNET) demonstrated a 16.5% improvement in F1 score and a 25% increase in Precision and Recall. DALL-M bridges an important gap in clinical data augmentation by preserving data integrity while enhancing predictive modeling in healthcare. Our results show that integrating LLM-generated synthetic features significantly improves model performance, making DALL-M a scalable and practical approach for AI-driven medical diagnostics.

Diogo J. Araújo, M. Rita Verdelho, Alceu Bissoto et al.

Deep learning models have revolutionized the field of medical image analysis, due to their outstanding performances. However, they are sensitive to spurious correlations, often taking advantage of dataset bias to improve results for in-domain data, but jeopardizing their generalization capabilities. In this paper, we propose to limit the amount of information these models use to reach the final classification, by using a multiple instance learning (MIL) framework. MIL forces the model to use only a (small) subset of patches in the image, identifying discriminative regions. This mimics the clinical procedures, where medical decisions are based on localized findings. We evaluate our framework on two medical applications: skin cancer diagnosis using dermoscopy and breast cancer diagnosis using mammography. Our results show that using only a subset of the patches does not compromise diagnostic performance for in-domain data, compared to the baseline approaches. However, our approach is more robust to shifts in patient demographics, while also providing more detailed explanations about which regions contributed to the decision. Code is available at: https://github.com/diogojpa99/MedicalMultiple-Instance-Learning.

Francisco Xavier Vasconcelos, Jacinto C. Nascimento

We present, for the first time, a novel theoretical approach to address the problem of correspondence free multivector cloud registration in conformal geometric algebra. Such formalism achieves several favorable properties. Primarily, it forms an orthogonal automorphism that extends beyond the typical vector space to the entire conformal geometric algebra while respecting the multivector grading. Concretely, the registration can be viewed as an orthogonal transformation (\it i.e., scale, translation, rotation) belonging to $SO(4,1)$ - group of special orthogonal transformations in conformal geometric algebra. We will show that such formalism is able to: $(i)$ perform the registration without directly accessing the input multivectors. Instead, we use primitives or geometric objects provided by the conformal model - the multivectors, $(ii)$ the geometric objects are obtained by solving a multilinear eigenvalue problem to find sets of eigenmultivectors. In this way, we can explicitly avoid solving the correspondences in the registration process. Most importantly, this offers rotation and translation equivariant properties between the input multivectors and the eigenmultivectors. Experimental evaluation is conducted in datasets commonly used in point cloud registration, to testify the usefulness of the approach with emphasis to ambiguities arising from high levels of noise. The code is available at https://github.com/Numerical-Geometric-Algebra/RegistrationGA . This work was submitted to the International Journal of Computer Vision and is currently under review.

G. Dias Pais, Srikumar Ramalingam, Venu Madhav Govindu et al.

We present 3DRegNet, a novel deep learning architecture for the registration of 3D scans. Given a set of 3D point correspondences, we build a deep neural network to address the following two challenges: (i) classification of the point correspondences into inliers/outliers, and (ii) regression of the motion parameters that align the scans into a common reference frame. With regard to regression, we present two alternative approaches: (i) a Deep Neural Network (DNN) registration and (ii) a Procrustes approach using SVD to estimate the transformation. Our correspondence-based approach achieves a higher speedup compared to competing baselines. We further propose the use of a refinement network, which consists of a smaller 3DRegNet as a refinement to improve the accuracy of the registration. Extensive experiments on two challenging datasets demonstrate that we outperform other methods and achieve state-of-the-art results. The code is available.

Siddhant Ranade, Gonçalo Dias Pais, Ross Tyler Whitaker et al.

We propose a fast and accurate surface reconstruction algorithm for unorganized point clouds using an implicit representation. Recent learning methods are either single-object representations with small neural models that allow for high surface details but require per-object training or generalized representations that require larger models and generalize to newer shapes but lack details, and inference is slow. We propose a new implicit representation for general 3D shapes that is faster than all the baselines at their optimum resolution, with only a marginal loss in performance compared to the state-of-the-art. We achieve the best accuracy-speed trade-off using three key contributions. Many implicit methods extract features from the point cloud to classify whether a query point is inside or outside the object. First, to speed up the reconstruction, we show that this feature extraction does not need to use the query point at an early stage (lazy query). Second, we use a parallel multi-scale grid representation to develop robust features for different noise levels and input resolutions. Finally, we show that attention across scales can provide improved reconstruction results.

Alexandre Duarte, Francisco Fernandes, João M. Pereira et al.

Depth maps produced by consumer-grade sensors suffer from inaccurate measurements and missing data from either system or scene-specific sources. Data-driven denoising algorithms can mitigate such problems. However, they require vast amounts of ground truth depth data. Recent research has tackled this limitation using self-supervised learning techniques, but it requires multiple RGB-D sensors. Moreover, most existing approaches focus on denoising single isolated depth maps or specific subjects of interest, highlighting a need for methods to effectively denoise depth maps in real-time dynamic environments. This paper extends state-of-the-art approaches for depth-denoising commodity depth devices, proposing SelfReDepth, a self-supervised deep learning technique for depth restoration, via denoising and hole-filling by inpainting full-depth maps captured with RGB-D sensors. The algorithm targets depth data in video streams, utilizing multiple sequential depth frames coupled with color data to achieve high-quality depth videos with temporal coherence. Finally, SelfReDepth is designed to be compatible with various RGB-D sensors and usable in real-time scenarios as a pre-processing step before applying other depth-dependent algorithms. Our results demonstrate our approach's real-time performance on real-world datasets. They show that it outperforms state-of-the-art denoising and restoration performance at over 30fps on Commercial Depth Cameras, with potential benefits for augmented and mixed-reality applications.

José Celestino, Manuel Marques, Jacinto C. Nascimento

Head pose estimation has become a crucial area of research in computer vision given its usefulness in a wide range of applications, including robotics, surveillance, or driver attention monitoring. One of the most difficult challenges in this field is managing head occlusions that frequently take place in real-world scenarios. In this paper, we propose a novel and efficient framework that is robust in real world head occlusion scenarios. In particular, we propose an unsupervised latent embedding clustering with regression and classification components for each pose angle. The model optimizes latent feature representations for occluded and non-occluded images through a clustering term while improving fine-grained angle predictions. Experimental evaluation on in-the-wild head pose benchmark datasets reveal competitive performance in comparison to state-of-the-art methodologies with the advantage of having a significant data reduction. We observe a substantial improvement in occluded head pose estimation. Also, an ablation study is conducted to ascertain the impact of the clustering term within our proposed framework.

Renato Hermoza, Gabriel Maicas, Jacinto C. Nascimento et al.

Overall survival (OS) time prediction is one of the most common estimates of the prognosis of gliomas and is used to design an appropriate treatment planning. State-of-the-art (SOTA) methods for OS time prediction follow a pre-hoc approach that require computing the segmentation map of the glioma tumor sub-regions (necrotic, edema tumor, enhancing tumor) for estimating OS time. However, the training of the segmentation methods require ground truth segmentation labels which are tedious and expensive to obtain. Given that most of the large-scale data sets available from hospitals are unlikely to contain such precise segmentation, those SOTA methods have limited applicability. In this paper, we introduce a new post-hoc method for OS time prediction that does not require segmentation map annotation for training. Our model uses medical image and patient demographics (represented by age) as inputs to estimate the OS time and to estimate a saliency map that localizes the tumor as a way to explain the OS time prediction in a post-hoc manner. It is worth emphasizing that although our model can localize tumors, it uses only the ground truth OS time as training signal, i.e., no segmentation labels are needed. We evaluate our post-hoc method on the Multimodal Brain Tumor Segmentation Challenge (BraTS) 2019 data set and show that it achieves competitive results compared to pre-hoc methods with the advantage of not requiring segmentation labels for training.

Renato Hermoza, Gabriel Maicas, Jacinto C. Nascimento et al.

The deployment of automated systems to diagnose diseases from medical images is challenged by the requirement to localise the diagnosed diseases to justify or explain the classification decision. This requirement is hard to fulfil because most of the training sets available to develop these systems only contain global annotations, making the localisation of diseases a weakly supervised approach. The main methods designed for weakly supervised disease classification and localisation rely on saliency or attention maps that are not specifically trained for localisation, or on region proposals that can not be refined to produce accurate detections. In this paper, we introduce a new model that combines region proposal and saliency detection to overcome both limitations for weakly supervised disease classification and localisation. Using the ChestX-ray14 data set, we show that our proposed model establishes the new state-of-the-art for weakly-supervised disease diagnosis and localisation.

Gabriel Maicas, Cuong Nguyen, Farbod Motlagh et al.

Meta-training has been empirically demonstrated to be the most effective pre-training method for few-shot learning of medical image classifiers (i.e., classifiers modeled with small training sets). However, the effectiveness of meta-training relies on the availability of a reasonable number of hand-designed classification tasks, which are costly to obtain, and consequently rarely available. In this paper, we propose a new method to unsupervisedly design a large number of classification tasks to meta-train medical image classifiers. We evaluate our method on a breast dynamically contrast enhanced magnetic resonance imaging (DCE-MRI) data set that has been used to benchmark few-shot training methods of medical image classifiers. Our results show that the proposed unsupervised task design to meta-train medical image classifiers builds a pre-trained model that, after fine-tuning, produces better classification results than other unsupervised and supervised pre-training methods, and competitive results with respect to meta-training that relies on hand-designed classification tasks.

G. Dias Pais, Tiago J. Dias, Jacinto C. Nascimento et al.

Pedestrian detection is one of the most explored topics in computer vision and robotics. The use of deep learning methods allowed the development of new and highly competitive algorithms. Deep Reinforcement Learning has proved to be within the state-of-the-art in terms of both detection in perspective cameras and robotics applications. However, for detection in omnidirectional cameras, the literature is still scarce, mostly because of their high levels of distortion. This paper presents a novel and efficient technique for robust pedestrian detection in omnidirectional images. The proposed method uses deep Reinforcement Learning that takes advantage of the distortion in the image. By considering the 3D bounding boxes and their distorted projections into the image, our method is able to provide the pedestrian's position in the world, in contrast to the image positions provided by most state-of-the-art methods for perspective cameras. Our method avoids the need of pre-processing steps to remove the distortion, which is computationally expensive. Beyond the novel solution, our method compares favorably with the state-of-the-art methodologies that do not consider the underlying distortion for the detection task.

Gabriel Maicas, Andrew P. Bradley, Jacinto C. Nascimento et al.

We propose a new method for breast cancer screening from DCE-MRI based on a post-hoc approach that is trained using weakly annotated data (i.e., labels are available only at the image level without any lesion delineation). Our proposed post-hoc method automatically diagnosis the whole volume and, for positive cases, it localizes the malignant lesions that led to such diagnosis. Conversely, traditional approaches follow a pre-hoc approach that initially localises suspicious areas that are subsequently classified to establish the breast malignancy -- this approach is trained using strongly annotated data (i.e., it needs a delineation and classification of all lesions in an image). Another goal of this paper is to establish the advantages and disadvantages of both approaches when applied to breast screening from DCE-MRI. Relying on experiments on a breast DCE-MRI dataset that contains scans of 117 patients, our results show that the post-hoc method is more accurate for diagnosing the whole volume per patient, achieving an AUC of 0.91, while the pre-hoc method achieves an AUC of 0.81. However, the performance for localising the malignant lesions remains challenging for the post-hoc method due to the weakly labelled dataset employed during training.

Gabriel Maicas, Andrew P. Bradley, Jacinto C. Nascimento et al.

The training of medical image analysis systems using machine learning approaches follows a common script: collect and annotate a large dataset, train the classifier on the training set, and test it on a hold-out test set. This process bears no direct resemblance with radiologist training, which is based on solving a series of tasks of increasing difficulty, where each task involves the use of significantly smaller datasets than those used in machine learning. In this paper, we propose a novel training approach inspired by how radiologists are trained. In particular, we explore the use of meta-training that models a classifier based on a series of tasks. Tasks are selected using teacher-student curriculum learning, where each task consists of simple classification problems containing small training sets. We hypothesize that our proposed meta-training approach can be used to pre-train medical image analysis models. This hypothesis is tested on the automatic breast screening classification from DCE-MRI trained with weakly labeled datasets. The classification performance achieved by our approach is shown to be the best in the field for that application, compared to state of art baseline approaches: DenseNet, multiple instance learning and multi-task learning.

Andre Mateus, David Ribeiro, Pedro Miraldo et al.

This paper addresses the problem of Human-Aware Navigation (HAN), using multi camera sensors to implement a vision-based person tracking system. The main contributions of this paper are as follows: a novel and efficient Deep Learning person detection and a standardization of human-aware constraints. In the first stage of the approach, we propose to cascade the Aggregate Channel Features (ACF) detector with a deep Convolutional Neural Network (CNN) to achieve fast and accurate Pedestrian Detection (PD). Regarding the human awareness (that can be defined as constraints associated with the robot's motion), we use a mixture of asymmetric Gaussian functions, to define the cost functions associated to each constraint. Both methods proposed herein are evaluated individually to measure the impact of each of the components. The final solution (including both the proposed pedestrian detection and the human-aware constraints) is tested in a typical domestic indoor scenario, in four distinct experiments. The results show that the robot is able to cope with human-aware constraints, defined after common proxemics and social rules.

David Ribeiro, Andre Mateus, Pedro Miraldo et al.

A real-time Deep Learning based method for Pedestrian Detection (PD) is applied to the Human-Aware robot navigation problem. The pedestrian detector combines the Aggregate Channel Features (ACF) detector with a deep Convolutional Neural Network (CNN) in order to obtain fast and accurate performance. Our solution is firstly evaluated using a set of real images taken from onboard and offboard cameras and, then, it is validated in a typical robot navigation environment with pedestrians (two distinct experiments are conducted). The results on both tests show that our pedestrian detector is robust and fast enough to be used on robot navigation applications.