Luis Felipe

Philippe E. Spiess, Md Muntasir Zitu, Alison Walker et al.

Background: More than 80% of U.S. cancer care is delivered in community settings, where survival remains worse than at academic centers. Clinicians must integrate genomics, staging, radiology, pathology, and changing guidelines, creating cognitive burden. We evaluated OncoBrain, an AI clinical reasoning platform for oncology treatment-plan generation, as an early step toward OGI. Methods: OncoBrain combines general-purpose LLMs with a cancer-specific graph retrieval-augmented generation layer, a gold-standard treatment-plan corpus as long-term memory, and a model-agnostic safety layer (CHECK) for hallucination detection and suppression. We evaluated clinician-enriched case summaries across gynecologic, genitourinary, neuro-oncology, gastrointestinal/hepatobiliary, and hematologic malignancies. Three clinician groups completed structured evaluations of 173 cases using a common 16-item instrument: subspecialist oncologists reviewed 50 cases, physician reviewers 78, and advanced practice providers 45. Results: Ratings were highest for scientific accuracy, evidence support, and safety, with lower but favorable scores for workflow integration and time savings. On a 5-point scale, mean alignment with evidence and guidelines was 4.60, 4.56, and 4.70 across subspecialists, physician reviewers, and advanced practice providers. Mean scores for absence of safety or misinformation concerns were 4.80, 4.40, and 4.60. Workflow integration averaged 4.50, 3.94, and 4.00; perceived time savings averaged 5.00, 3.89, and 3.60. Conclusions: In this multi-specialty vignette-based evaluation, OncoBrain generated oncology treatment plans judged guideline-concordant, clinically acceptable, and easy to supervise. These findings support the potential of a carefully engineered AI reasoning platform to assist oncology treatment planning and justify prospective real-world evaluation in community settings.

Carlos Garcia-Fernandez, Luis Felipe, Monique Shotande et al.

Large language models (LLMs) show promise in healthcare, but hallucinations remain a major barrier to clinical use. We present CHECK, a continuous-learning framework that integrates structured clinical databases with a classifier grounded in information theory to detect both factual and reasoning-based hallucinations. Evaluated on 1500 questions from 100 pivotal clinical trials, CHECK reduced LLama3.3-70B-Instruct hallucination rates from 31% to 0.3% - making an open source model state of the art. Its classifier generalized across medical benchmarks, achieving AUCs of 0.95-0.96, including on the MedQA (USMLE) benchmark and HealthBench realistic multi-turn medical questioning. By leveraging hallucination probabilities to guide GPT-4o's refinement and judiciously escalate compute, CHECK boosted its USMLE passing rate by 5 percentage points, achieving a state-of-the-art 92.1%. By suppressing hallucinations below accepted clinical error thresholds, CHECK offers a scalable foundation for safe LLM deployment in medicine and other high-stakes domains.

Luis Felipe, Carlos Garcia, Issam El Naqa et al.

The need for robust and diverse data sets to train clinical large language models (cLLMs) is critical given that currently available public repositories often prove too limited in size or scope for comprehensive medical use. While resources like PubMed provide foundational medical literature, they capture only a narrow range of formal publications and omit the broader medical discourse on the internet. To address these deficits, we introduce TheBlueScrubs-v1, a curated dataset of over 25 billion medical tokens - nearly three times larger than PubMed - drawn from a broad-scale internet corpus. Our two-stage filtering pipeline employs a Logistic Regression model for document screening (achieving an AUC of approximately 0.95 on external validation), followed by verification via a 70B-parameter Llama 3.1 instruct model. Each text is assigned three LLM-based quality scores encompassing medical relevance, precision and factual detail, and safety and ethical standards. Clinician reviews confirm high concordance with these automated evaluations, and a specialized cancer classifier further labels approximately 11 billion oncology tokens. Two demonstration tasks highlight the dataset's practical value: first, we distill the safety evaluations to a smaller BERT-style model that reaches an AUC near 0.96 on unseen data; second, we fine-tune a compact LLM on a filtered subset, showing measurable improvements over standard baselines in medical benchmarks as well as private ones. This Data Descriptor details the dataset's creation and validation, underscoring its potential utility for medical AI research.