Eleonora Vercesi

Koppány István Encz, Monaldo Mastrolilli, Eleonora Vercesi

Branch-and-bound algorithms (B&B) and polynomial-time approximation schemes (PTAS) are two seemingly distant areas of combinatorial optimization. We intend to (partially) bridge the gap between them while expanding the boundary of theoretical knowledge on the B\&B framework. Branch-and-bound algorithms typically guarantee that an optimal solution is eventually found. However, we show that the standard implementation of branch-and-bound for certain knapsack and scheduling problems also exhibits PTAS-like behavior, yielding increasingly better solutions within polynomial time. Our findings are supported by computational experiments and comparisons with benchmark methods. This paper is an extended version of a paper accepted at ICALP 2025

Riccardo Bellazzi, Andrea Codegoni, Stefano Gualandi et al.

This paper introduces the Gene Mover's Distance, a measure of similarity between a pair of cells based on their gene expression profiles obtained via single-cell RNA sequencing. The underlying idea of the proposed distance is to interpret the gene expression array of a single cell as a discrete probability measure. The distance between two cells is hence computed by solving an Optimal Transport problem between the two corresponding discrete measures. In the Optimal Transport model, we use two types of cost function for measuring the distance between a pair of genes. The first cost function exploits a gene embedding, called gene2vec, which is used to map each gene to a high dimensional vector: the cost of moving a unit of mass of gene expression from a gene to another is set to the Euclidean distance between the corresponding embedded vectors. The second cost function is based on a Pearson distance among pairs of genes. In both cost functions, the more two genes are correlated, the lower is their distance. We exploit the Gene Mover's Distance to solve two classification problems: the classification of cells according to their condition and according to their type. To assess the impact of our new metric, we compare the performances of a $k$-Nearest Neighbor classifier using different distances. The computational results show that the Gene Mover's Distance is competitive with the state-of-the-art distances used in the literature.