Kannie W. Y. Chan

Chu Chen, Yang Liu, Se Weon Park et al.

Chemical Exchange Saturation Transfer (CEST) MRI demonstrates its capability in significantly enhancing the detection of proteins and metabolites with low concentrations through exchangeable protons. The clinical application of CEST, however, is constrained by its low contrast and low signal-to-noise ratio (SNR) in the acquired data. Denoising, as one of the post-processing stages for CEST data, can effectively improve the accuracy of CEST quantification. In this work, by modeling spatial variant z-spectrums into low-dimensional subspace, we introduce Implicit Regression in Subspace (IRIS), which is an unsupervised denoising algorithm utilizing the excellent property of implicit neural representation for continuous mapping. Experiments conducted on both synthetic and in-vivo data demonstrate that our proposed method surpasses other CEST denoising methods regarding both qualitative and quantitative performance.

Rushuang Zhou, Lei Clifton, Zijun Liu et al.

The label scarcity problem is the main challenge that hinders the wide application of deep learning systems in automatic cardiovascular diseases (CVDs) detection using electrocardiography (ECG). Tuning pre-trained models alleviates this problem by transferring knowledge learned from large datasets to downstream small datasets. However, bottlenecks in computational efficiency and detection performance limit its clinical applications. It is difficult to improve the detection performance without significantly sacrificing the computational efficiency during model training. Here, we propose a computation-efficient semi-supervised learning paradigm (CE-SSL) for robust and computation-efficient CVDs detection using ECG. It enables a robust adaptation of pre-trained models on downstream datasets with limited supervision and high computational efficiency. First, a random-deactivation technique is developed to achieve robust and fast low-rank adaptation of pre-trained weights. Subsequently, we propose a one-shot rank allocation module to determine the optimal ranks for the update matrices of the pre-trained weights. Finally, a lightweight semi-supervised learning pipeline is introduced to enhance model performance by leveraging labeled and unlabeled data with high computational efficiency. Extensive experiments on four downstream datasets demonstrate that CE-SSL not only outperforms the state-of-the-art methods in multi-label CVDs detection but also consumes fewer GPU footprints, training time, and parameter storage space. As such, this paradigm provides an effective solution for achieving high computational efficiency and robust detection performance in the clinical applications of pre-trained models under limited supervision. Code and Supplementary Materials are available at https://github.com/KAZABANA/CE-SSL

Dengqiang Jia, Xinnian Yang, Xiaosong Xiong et al.

Vessel dynamics simulation is vital in studying the relationship between geometry and vascular disease progression. Reliable dynamics simulation relies on high-quality vascular meshes. Most of the existing mesh generation methods highly depend on manual annotation, which is time-consuming and laborious, usually facing challenges such as branch merging and vessel disconnection. This will hinder vessel dynamics simulation, especially for the population study. To address this issue, we propose a deep learning-based method, dubbed as DVasMesh to directly generate structured hexahedral vascular meshes from vascular images. Our contributions are threefold. First, we propose to formally formulate each vertex of the vascular graph by a four-element vector, including coordinates of the centerline point and the radius. Second, a vectorized graph template is employed to guide DVasMesh to estimate the vascular graph. Specifically, we introduce a sampling operator, which samples the extracted features of the vascular image (by a segmentation network) according to the vertices in the template graph. Third, we employ a graph convolution network (GCN) and take the sampled features as nodes to estimate the deformation between vertices of the template graph and target graph, and the deformed graph template is used to build the mesh. Taking advantage of end-to-end learning and discarding direct dependency on annotated labels, our DVasMesh demonstrates outstanding performance in generating structured vascular meshes on cardiac and cerebral vascular images. It shows great potential for clinical applications by reducing mesh generation time from 2 hours (manual) to 30 seconds (automatic).

Chu Chen, Aitor Artola, Yang Liu et al.

Chemical Exchange Saturation Transfer (CEST) MRI enables molecular-level visualization of low-concentration metabolites by leveraging proton exchange dynamics. However, its clinical translation is hindered by inherent challenges: spatially varying noise arising from hardware limitations, and complex imaging protocols introduce heteroscedasticity in CEST data, perturbing the accuracy of quantitative contrast mapping such as amide proton transfer (APT) imaging. Traditional denoising methods are not designed for this complex noise and often alter the underlying information that is critical for biomedical analysis. To overcome these limitations, we propose a new Blind Adaptive Local Denoising (BALD) method. BALD exploits the self-similar nature of CEST data to derive an adaptive variance-stabilizing transform that equalizes the noise distributions across CEST pixels without prior knowledge of noise characteristics. Then, BALD performs two-stage denoising on a linear transformation of data to disentangle molecular signals from noise. A local SVD decomposition is used as a linear transform to prevent spatial and spectral denoising artifacts. We conducted extensive validation experiments on multiple phantoms and \textit{in vivo} CEST scans. In these experiments, BALD consistently outperformed state-of-the-art CEST denoisers in both denoising metrics and downstream tasks such as molecular concentration maps estimation and cancer detection.