Benjamin D. Killeen

Benjamin D. Killeen, Han Zhang, Jan Mangulabnan et al.

Surgical phase recognition (SPR) is a crucial element in the digital transformation of the modern operating theater. While SPR based on video sources is well-established, incorporation of interventional X-ray sequences has not yet been explored. This paper presents Pelphix, a first approach to SPR for X-ray-guided percutaneous pelvic fracture fixation, which models the procedure at four levels of granularity -- corridor, activity, view, and frame value -- simulating the pelvic fracture fixation workflow as a Markov process to provide fully annotated training data. Using added supervision from detection of bony corridors, tools, and anatomy, we learn image representations that are fed into a transformer model to regress surgical phases at the four granularity levels. Our approach demonstrates the feasibility of X-ray-based SPR, achieving an average accuracy of 93.8% on simulated sequences and 67.57% in cadaver across all granularity levels, with up to 88% accuracy for the target corridor in real data. This work constitutes the first step toward SPR for the X-ray domain, establishing an approach to categorizing phases in X-ray-guided surgery, simulating realistic image sequences to enable machine learning model development, and demonstrating that this approach is feasible for the analysis of real procedures. As X-ray-based SPR continues to mature, it will benefit procedures in orthopedic surgery, angiography, and interventional radiology by equipping intelligent surgical systems with situational awareness in the operating room.

Cong Gao, Benjamin D. Killeen, Yicheng Hu et al.

Artificial intelligence (AI) now enables automated interpretation of medical images for clinical use. However, AI's potential use for interventional images (versus those involved in triage or diagnosis), such as for guidance during surgery, remains largely untapped. This is because surgical AI systems are currently trained using post hoc analysis of data collected during live surgeries, which has fundamental and practical limitations, including ethical considerations, expense, scalability, data integrity, and a lack of ground truth. Here, we demonstrate that creating realistic simulated images from human models is a viable alternative and complement to large-scale in situ data collection. We show that training AI image analysis models on realistically synthesized data, combined with contemporary domain generalization or adaptation techniques, results in models that on real data perform comparably to models trained on a precisely matched real data training set. Because synthetic generation of training data from human-based models scales easily, we find that our model transfer paradigm for X-ray image analysis, which we refer to as SyntheX, can even outperform real data-trained models due to the effectiveness of training on a larger dataset. We demonstrate the potential of SyntheX on three clinical tasks: Hip image analysis, surgical robotic tool detection, and COVID-19 lung lesion segmentation. SyntheX provides an opportunity to drastically accelerate the conception, design, and evaluation of intelligent systems for X-ray-based medicine. In addition, simulated image environments provide the opportunity to test novel instrumentation, design complementary surgical approaches, and envision novel techniques that improve outcomes, save time, or mitigate human error, freed from the ethical and practical considerations of live human data collection.

Miriam Senne, Benjamin D. Killeen, Christoph Baur et al.

Body shape and circumferences are clinically informative biomarkers for risk stratification, including measures such as waist to hip ratio, limb and trunk girths, yet conventional tools such as manual tape measures and optical scanners often require undressing and sustained poses. These demands slow workflows, compromise dignity, and exclude many older adults and people with limited mobility. To make measurement fast and contactless, we leverage millimeter-wave (mmWave) radar, which preserves privacy and operates through typical clothing, enabling quick full-body acquisition. In this work, we present a new optimization-based framework to recover 3D human shape and extract a comprehensive set of anthropometric measurements from volumetric mmWave data. Our method introduces a weighted registration pipeline that fits a parametric body model (SMPL) directly to the noisy mmWave point cloud. The core of our contribution is a vertex-weighting strategy that modulates a Chamfer energy function for reliable surface alignment and noise elimination. We further stabilize the fit by incorporating a foot-ground plane constraint and pose priors, optimizing directly for the SMPL parameters. Together, these components enable a fast, privacy preserving workflow that delivers high fidelity body shape and measurements through clothing without cameras or disrobing and with minimal cooperation, supporting frequent risk oriented assessments in clinics and care facilities for patients of all ages and mobility levels.

Florence Klitzner, Blanca Inigo, Benjamin D. Killeen et al.

Imitation learning-based robot control policies are enjoying renewed interest in video-based robotics. However, it remains unclear whether this approach applies to X-ray-guided procedures, such as spine instrumentation. This is because interpretation of multi-view X-rays is complex. We examine opportunities and challenges for imitation policy learning in bi-plane-guided cannula insertion. We develop an in silico sandbox for scalable, automated simulation of X-ray-guided spine procedures with a high degree of realism. We curate a dataset of correct trajectories and corresponding bi-planar X-ray sequences that emulate the stepwise alignment of providers. We then train imitation learning policies for planning and open-loop control that iteratively align a cannula solely based on visual information. This precisely controlled setup offers insights into limitations and capabilities of this method. Our policy succeeded on the first attempt in 68.5% of cases, maintaining safe intra-pedicular trajectories across diverse vertebral levels. The policy generalized to complex anatomy, including fractures, and remained robust to varied initializations. Rollouts on real bi-planar X-rays further suggest that the model can produce plausible trajectories, despite training exclusively in simulation. While these preliminary results are promising, we also identify limitations, especially in entry point precision. Full closed-look control will require additional considerations around how to provide sufficiently frequent feedback. With more robust priors and domain knowledge, such models may provide a foundation for future efforts toward lightweight and CT-free robotic intra-operative spinal navigation.

Benjamin D. Killeen, Liam J. Wang, Blanca Inigo et al.

Language promptable X-ray image segmentation would enable greater flexibility for human-in-the-loop workflows in diagnostic and interventional precision medicine. Prior efforts have contributed task-specific models capable of solving problems within a narrow scope, but expanding to broader use requires additional data, annotations, and training time. Recently, language-aligned foundation models (LFMs) -- machine learning models trained on large amounts of highly variable image and text data thus enabling broad applicability -- have emerged as promising tools for automated image analysis. Existing foundation models for medical image analysis focus on scenarios and modalities where large, richly annotated datasets are available. However, the X-ray imaging modality features highly variable image appearance and applications, from diagnostic chest X-rays to interventional fluoroscopy, with varying availability of data. To pave the way toward an LFM for comprehensive and language-aligned analysis of arbitrary medical X-ray images, we introduce FluoroSAM, a language-promptable variant of the Segment Anything Model, trained from scratch on 3M synthetic X-ray images from a wide variety of human anatomies, imaging geometries, and viewing angles. These include pseudo-ground truth masks for 128 organ types and 464 tools with associated text descriptions. FluoroSAM is capable of segmenting myriad anatomical structures and tools based on natural language prompts, thanks to the novel incorporation of vector quantization (VQ) of text embeddings in the training process. We demonstrate FluoroSAM's performance quantitatively on real X-ray images and showcase on several applications how FluoroSAM is a key enabler for rich human-machine interaction in the X-ray image acquisition and analysis context. Code is available at https://github.com/arcadelab/fluorosam.

Miriam Senne, Benjamin D. Killeen, Tony Wang et al.

Body composition assessment (BCA) provides detailed information about the distribution of different tissue types in the body, enabling more precise characterization of individuals than BMI or weight alone. Consistent and frequent BCA would be valuable for personalized medicine, but the gold standard methods for BCA, such as CT and MRI, are only practical for opportunistic monitoring of patients with clinical indications for imaging and are not suitable for routine use in the general population. Here, we consider an imaging modality which is not currently used in medical applications: millimeter wave (mmWave) radar. Commonly used in security settings, mmWave scans enable fast, non-intrusive, and privacy-preserving reconstruction of full body shape without the need to remove clothing. To demonstrate the feasibility of fast and convenient BCA from mmWave scans, we present a method for BCA value regression using a multi-task learning strategy that leverages synthetic mmWave-like point clouds derived from clinical imaging and parametric human models. We evaluate the model on a pilot cohort of real mmWave scans with bioimpedance-derived body fat measurements, supporting the feasibility of estimating VAT and body fat percentage (BFP) from mmWave data acquired through clothing in a standing posture. We find that the model can predict VAT and BFP with a mean absolute error of 1.0 L and 3.2\%, respectively, demonstrating the potential of mmWave scanning for routine BCA in a wide range of settings.

Benjamin D. Killeen, Anushri Suresh, Catalina Gomez et al.

Natural language offers a convenient, flexible interface for controlling robotic C-arm X-ray systems, making advanced functionality and controls accessible. However, enabling language interfaces requires specialized AI models that interpret X-ray images to create a semantic representation for reasoning. The fixed outputs of such AI models limit the functionality of language controls. Incorporating flexible, language-aligned AI models prompted through language enables more versatile interfaces for diverse tasks and procedures. Using a language-aligned foundation model for X-ray image segmentation, our system continually updates a patient digital twin based on sparse reconstructions of desired anatomical structures. This supports autonomous capabilities such as visualization, patient-specific viewfinding, and automatic collimation from novel viewpoints, enabling commands 'Focus in on the lower lumbar vertebrae.' In a cadaver study, users visualized, localized, and collimated structures across the torso using verbal commands, achieving 84% end-to-end success. Post hoc analysis of randomly oriented images showed our patient digital twin could localize 35 commonly requested structures to within 51.68 mm, enabling localization and isolation from arbitrary orientations. Our results demonstrate how intelligent robotic X-ray systems can incorporate physicians' expressed intent directly. While existing foundation models for intra-operative X-ray analysis exhibit failure modes, as they improve, they can facilitate highly flexible, intelligent robotic C-arms.

Han Zhang, Lalithkumar Seenivasan, Jose L. Porras et al.

Observing surgical practice has historically relied on fixed vantage points or recollections, leaving the egocentric visual perspectives that guide clinical decisions undocumented. Fixed-camera video can capture surgical workflows at the room-scale, but cannot reconstruct what each team member actually saw. Thus, these videos only provide limited insights into how decisions that affect surgical safety, training, and workflow optimization are made. Here we introduce EgoSurg, the first framework to reconstruct the dynamic, egocentric replays for any operating room (OR) staff directly from wall-mounted fixed-camera video, and thus, without intervention to clinical workflow. EgoSurg couples geometry-driven neural rendering with diffusion-based view enhancement, enabling high-visual fidelity synthesis of arbitrary and egocentric viewpoints at any moment. In evaluation across multi-site surgical cases and controlled studies, EgoSurg reconstructs person-specific visual fields and arbitrary viewpoints with high visual quality and fidelity. By transforming existing OR camera infrastructure into a navigable dynamic 3D record, EgoSurg establishes a new foundation for immersive surgical data science, enabling surgical practice to be visualized, experienced, and analyzed from every angle.

Blanca Inigo, Yiqing Shen, Benjamin D. Killeen et al.

Vertebral compression fractures (VCFs) are a common and potentially serious consequence of osteoporosis. Yet, they often remain undiagnosed. Opportunistic screening, which involves automated analysis of medical imaging data acquired primarily for other purposes, is a cost-effective method to identify undiagnosed VCFs. In high-stakes scenarios like opportunistic medical diagnosis, model interpretability is a key factor for the adoption of AI recommendations. Rule-based methods are inherently explainable and closely align with clinical guidelines, but they are not immediately applicable to high-dimensional data such as CT scans. To address this gap, we introduce a neurosymbolic approach for VCF detection in CT volumes. The proposed model combines deep learning (DL) for vertebral segmentation with a shape-based algorithm (SBA) that analyzes vertebral height distributions in salient anatomical regions. This allows for the definition of a rule set over the height distributions to detect VCFs. Evaluation of VerSe19 dataset shows that our method achieves an accuracy of 96% and a sensitivity of 91% in VCF detection. In comparison, a black box model, DenseNet, achieved an accuracy of 95% and sensitivity of 91% in the same dataset. Our results demonstrate that our intrinsically explainable approach can match or surpass the performance of black box deep neural networks while providing additional insights into why a prediction was made. This transparency can enhance clinician's trust thus, supporting more informed decision-making in VCF diagnosis and treatment planning.

Maximilian Fehrentz, Nicolas Stellwag, Robert Wiebe et al.

Spatiotemporal reasoning is a fundamental capability for artificial intelligence (AI) in soft tissue surgery, paving the way for intelligent assistive systems and autonomous robotics. While 2D vision-language models show increasing promise at understanding surgical video, the spatial complexity of surgical scenes suggests that reasoning systems may benefit from explicit 4D representations. Here, we propose a framework for equipping surgical agents with spatiotemporal tools based on an explicit 4D representation, enabling AI systems to ground their natural language reasoning in both time and 3D space. Leveraging models for point tracking, depth, and segmentation, we develop a coherent 4D model with spatiotemporally consistent tool and tissue semantics. A Multimodal Large Language Model (MLLM) then acts as an agent on tools derived from the explicit 4D representation (e.g., trajectories) without any fine-tuning. We evaluate our method on a new dataset of 134 clinically relevant questions and find that the combination of a general purpose reasoning backbone and our 4D representation significantly improves spatiotemporal understanding and allows for 4D grounding. We demonstrate that spatiotemporal intelligence can be "assembled" from 2D MLLMs and 3D computer vision models without additional training. Code, data, and examples are available at https://tum-ai.github.io/surg4d/

Blanca Inigo, Benjamin D. Killeen, Rebecca Choi et al.

Robotic systems are transforming image-guided interventions by enhancing accuracy and minimizing radiation exposure. A significant challenge in robotic assistance lies in surgical path planning, which often relies on the registration of intraoperative 2D images with preoperative 3D CT scans. This requirement can be burdensome and costly, particularly in procedures like vertebroplasty, where preoperative CT scans are not routinely performed. To address this issue, we introduce a differentiable rendering-based framework for 3D transpedicular path planning utilizing bi-planar 2D X-rays. Our method integrates differentiable rendering with a vertebral atlas generated through a Statistical Shape Model (SSM) and employs a learned similarity loss to refine the SSM shape and pose dynamically, independent of fixed imaging geometries. We evaluated our framework in two stages: first, through vertebral reconstruction from orthogonal X-rays for benchmarking, and second, via clinician-in-the-loop path planning using arbitrary-view X-rays. Our results indicate that our method outperformed a normalized cross-correlation baseline in reconstruction metrics (DICE: 0.75 vs. 0.65) and achieved comparable performance to the state-of-the-art model ReVerteR (DICE: 0.77), while maintaining generalization to arbitrary views. Success rates for bipedicular planning reached 82% with synthetic data and 75% with cadaver data, exceeding the 66% and 31% rates of a 2D-to-3D baseline, respectively. In conclusion, our framework facilitates versatile, CT-free 3D path planning for robot-assisted vertebroplasty, effectively accommodating real-world imaging diversity without the need for preoperative CT scans.

Yudi Sang, Yanzhen Liu, Sutuke Yibulayimu et al.

The segmentation of pelvic fracture fragments in CT and X-ray images is crucial for trauma diagnosis, surgical planning, and intraoperative guidance. However, accurately and efficiently delineating the bone fragments remains a significant challenge due to complex anatomy and imaging limitations. The PENGWIN challenge, organized as a MICCAI 2024 satellite event, aimed to advance automated fracture segmentation by benchmarking state-of-the-art algorithms on these complex tasks. A diverse dataset of 150 CT scans was collected from multiple clinical centers, and a large set of simulated X-ray images was generated using the DeepDRR method. Final submissions from 16 teams worldwide were evaluated under a rigorous multi-metric testing scheme. The top-performing CT algorithm achieved an average fragment-wise intersection over union (IoU) of 0.930, demonstrating satisfactory accuracy. However, in the X-ray task, the best algorithm attained an IoU of 0.774, highlighting the greater challenges posed by overlapping anatomical structures. Beyond the quantitative evaluation, the challenge revealed methodological diversity in algorithm design. Variations in instance representation, such as primary-secondary classification versus boundary-core separation, led to differing segmentation strategies. Despite promising results, the challenge also exposed inherent uncertainties in fragment definition, particularly in cases of incomplete fractures. These findings suggest that interactive segmentation approaches, integrating human decision-making with task-relevant information, may be essential for improving model reliability and clinical applicability.

Benjamin D. Killeen, Bohua Wan, Aditya V. Kulkarni et al.

Artificial intelligence (AI) is poised to transform healthcare by enabling personalized and efficient care through data-driven insights. Although radiology is at the forefront of AI adoption, in practice, the potential of AI models is often overshadowed by severe failures to generalize: AI models can have performance degradation of up to 20% when transitioning from controlled test environments to clinical use by radiologists. This mismatch raises concerns that radiologists will be misled by incorrect AI predictions in practice and/or grow to distrust AI, rendering these promising technologies practically ineffectual. Exhaustive clinical trials of AI models on abundant and diverse data is thus critical to anticipate AI model degradation when encountering varied data samples. Achieving these goals, however, is challenging due to the high costs of collecting diverse data samples and corresponding annotations. To overcome these limitations, we introduce a novel conditional generative AI model designed for virtual clinical trials (VCTs) of radiology AI, capable of realistically synthesizing full-body CT images of patients with specified attributes. By learning the joint distribution of images and anatomical structures, our model enables precise replication of real-world patient populations with unprecedented detail at this scale. We demonstrate meaningful evaluation of radiology AI models through VCTs powered by our synthetic CT study populations, revealing model degradation and facilitating algorithmic auditing for bias-inducing data attributes. Our generative AI approach to VCTs is a promising avenue towards a scalable solution to assess model robustness, mitigate biases, and safeguard patient care by enabling simpler testing and evaluation of AI models in any desired range of diverse patient populations.