Yasaman Torabi

Yasaman Torabi, Parsa Razmara, Hamed Ajorlou et al.

Large Language Models (LLMs) have demonstrated strong semantic reasoning across multimodal domains. However, their integration with graph-based models of brain connectivity remains limited. In addition, most existing fMRI analysis methods rely on static Functional Connectivity (FC) representations, which obscure transient neural dynamics critical for neurodevelopmental disorders such as autism. Recent state-space approaches, including Mamba, model temporal structure efficiently, but are typically used as standalone feature extractors without explicit high-level reasoning. We propose NeuroMambaLLM, an end-to-end framework that integrates dynamic latent graph learning and selective state-space temporal modelling with LLMs. The proposed method learns the functional connectivity dynamically from raw Blood-Oxygen-Level-Dependent (BOLD) time series, replacing fixed correlation graphs with adaptive latent connectivity while suppressing motion-related artifacts and capturing long-range temporal dependencies. The resulting dynamic brain representations are projected into the embedding space of an LLM model, where the base language model remains frozen and lightweight low-rank adaptation (LoRA) modules are trained for parameter-efficient alignment. This design enables the LLM to perform both diagnostic classification and language-based reasoning, allowing it to analyze dynamic fMRI patterns and generate clinically meaningful textual reports.

Yasaman Torabi, Shahram Shirani, James P. Reilly

Heart and lung sounds are crucial for healthcare monitoring. Recent improvements in stethoscope technology have made it possible to capture patient sounds with enhanced precision. In this dataset, we used a digital stethoscope to capture both heart and lung sounds, including individual and mixed recordings. To our knowledge, this is the first dataset to offer both separate and mixed cardiorespiratory sounds. The recordings were collected from a clinical manikin, a patient simulator designed to replicate human physiological conditions, generating clean heart and lung sounds at different body locations. This dataset includes both normal sounds and various abnormalities (i.e., murmur, atrial fibrillation, tachycardia, atrioventricular block, third and fourth heart sound, wheezing, crackles, rhonchi, pleural rub, and gurgling sounds). The dataset includes audio recordings of chest examinations performed at different anatomical locations, as determined by specialist nurses. Each recording has been enhanced using frequency filters to highlight specific sound types. This dataset is useful for applications in artificial intelligence, such as automated cardiopulmonary disease detection, sound classification, unsupervised separation techniques, and deep learning algorithms related to audio signal processing.

Yasaman Torabi, Shahram Shirani, James P. Reilly

Early identification of abnormal physiological patterns is essential for the timely detection of cardiac disease. This work introduces a hybrid quantum-classical convolutional neural network (QCNN) designed to classify S3 and murmur abnormalities in heart sound signals. The approach transforms one-dimensional phonocardiogram (PCG) signals into compact two-dimensional images through a combination of wavelet feature extraction and adaptive threshold compression methods. We compress the cardiac-sound patterns into an 8-pixel image so that only 8 qubits are needed for the quantum stage. Preliminary results on the HLS-CMDS dataset demonstrate 93.33% classification accuracy on the test set and 97.14% on the train set, suggesting that quantum models can efficiently capture temporal-spectral correlations in biomedical signals. To our knowledge, this is the first application of a QCNN algorithm for bioacoustic signal processing. The proposed method represents an early step toward quantum-enhanced diagnostic systems for resource-constrained healthcare environments.

Yasaman Torabi, Shahram Shirani, James P. Reilly

Non-Negative Matrix Factorization (NMF) is an unsupervised learning method offering low-rank representations across various domains such as audio processing, biomedical signal analysis, and image recognition. The incorporation of $α$-divergence in NMF formulations enhances flexibility in optimization, yet extending these methods to multi-layer architectures presents challenges in ensuring convergence. To address this, we introduce a novel approach inspired by the Boltzmann probability of the energy barriers in chemical reactions to theoretically perform convergence analysis. We introduce a novel method, called Chem-NMF, with a bounding factor which stabilizes convergence. To our knowledge, this is the first study to apply a physical chemistry perspective to rigorously analyze the convergence behaviour of the NMF algorithm. We start from mathematically proven asymptotic convergence results and then show how they apply to real data. Experimental results demonstrate that the proposed algorithm improves clustering accuracy by 5.6% $\pm$ 2.7% on biomedical signals and 11.1% $\pm$ 7.2% on face images (mean $\pm$ std).

Yasaman Torabi, Shahram Shirani, James P. Reilly et al.

This paper presents a comprehensive review of cardiorespiratory auscultation sensing devices (i.e., stethoscopes), which is useful for understanding the theoretical aspects and practical design notes. In this paper, we first introduce the acoustic properties of the heart and lungs, as well as a brief history of stethoscope evolution. Then, we discuss the basic concept of electret condenser microphones (ECMs) and a stethoscope based on them. Then, we discuss the microelectromechanical systems (MEMSs) technology, particularly focusing on piezoelectric transducer sensors. This paper comprehensively reviews sensing technologies for cardiorespiratory auscultation, emphasizing MEMS-based wearable designs in the past decade. To our knowledge, this is the first paper to summarize ECM and MEMS applications for heart and lung sound analysis.