Junfeng Liu

Rui Li, Junfeng Liu, Xiangwen Kong et al.

Large Language Models (LLMs) as judges across various scenarios such as assessing model responses is becoming an increasingly accepted paradigm. However, existing judgment approaches often rely on trained judgers using fixed preference data, which tend to overlook diverse user preferences and struggle to adapt to real-world human-AI dialogue scenarios. To address these limitations, we propose SenseJudge, a customizable judgment framework driven by human preferences and SenseBench, a diverse and challenging instruction-following benchmark derived from real-world multi-turn interactions. We applied the automatic judgment framework and benchmark to two tasks: (1) LLMs as personalized judges, and (2) model ranking. We conducted extensive experiments, and the results demonstrate that the SenseJudge framework surpasses other judgment methods and models in the LLMs-as-personalized-judges task and achieves model ranking that aligns with real human sense. Additionally, we conducted analyses on position bias and consistency, alongside ablation studies, which affirmed the robustness of SenseJudge.

Ailin Huang, Chengyuan Yao, Chunrui Han et al.

We present STEP3-VL-10B, a lightweight open-source foundation model designed to redefine the trade-off between compact efficiency and frontier-level multimodal intelligence. STEP3-VL-10B is realized through two strategic shifts: first, a unified, fully unfrozen pre-training strategy on 1.2T multimodal tokens that integrates a language-aligned Perception Encoder with a Qwen3-8B decoder to establish intrinsic vision-language synergy; and second, a scaled post-training pipeline featuring over 1k iterations of reinforcement learning. Crucially, we implement Parallel Coordinated Reasoning (PaCoRe) to scale test-time compute, allocating resources to scalable perceptual reasoning that explores and synthesizes diverse visual hypotheses. Consequently, despite its compact 10B footprint, STEP3-VL-10B rivals or surpasses models 10$\times$-20$\times$ larger (e.g., GLM-4.6V-106B, Qwen3-VL-235B) and top-tier proprietary flagships like Gemini 2.5 Pro and Seed-1.5-VL. Delivering best-in-class performance, it records 92.2% on MMBench and 80.11% on MMMU, while excelling in complex reasoning with 94.43% on AIME2025 and 75.95% on MathVision. We release the full model suite to provide the community with a powerful, efficient, and reproducible baseline.

Ailin Huang, Ang Li, Aobo Kong et al.

We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.

Junfeng Liu, Christopher Symons, Ranga Raju Vatsavai

Conversational AI has become an increasingly prominent and practical application of machine learning. However, existing conversational AI techniques still suffer from various limitations. One such limitation is a lack of well-developed methods for incorporating auxiliary information that could help a model understand conversational context better. In this paper, we explore how persona-based information could help improve the quality of response generation in conversations. First, we provide a literature review focusing on the current state-of-the-art methods that utilize persona information. We evaluate two strong baseline methods, the Ranking Profile Memory Network and the Poly-Encoder, on the NeurIPS ConvAI2 benchmark dataset. Our analysis elucidates the importance of incorporating persona information into conversational systems. Additionally, our study highlights several limitations with current state-of-the-art methods and outlines challenges and future research directions for advancing personalized conversational AI technology.

Junfeng Liu, Min Zhou, Shuai Ma et al.

Graph Edit Distance (GED) is a general and domain-agnostic metric to measure graph similarity, widely used in graph search or retrieving tasks. However, the exact GED computation is known to be NP-complete. For instance, the widely used A* algorithms explore the entire search space to find the optimal solution which inevitably suffers scalability issues. Learning-based methods apply graph representation techniques to learn the GED by formulating a regression task, which can not recover the edit path and lead to inaccurate GED approximation (i.e., the predicted GED is smaller than the exact). To this end, in this work, we present a data-driven hybrid approach MATA* for approximate GED computation based on Graph Neural Networks (GNNs) and A* algorithms, which models from the perspective of learning to match nodes instead of directly regressing GED. Specifically, aware of the structure-dominant operations (i.e.,node and edge insertion/deletion) property in GED computation, a structure-enhanced GNN is firstly designed to jointly learn local and high-order structural information for node embeddings for node matchings. Second, top-k candidate nodes are produced via a differentiable top-k operation to enable the training for node matchings, which is adhering to another property of GED, i.e., multiple optimal node matchings. Third, benefiting from the candidate nodes, MATA* only performs on the promising search directions, reaching the solution efficiently. Finally, extensive experiments show the superiority of MATA* as it significantly outperforms the combinatorial search-based, learning-based and hybrid methods and scales well to large-size graphs.

Liwei Ni, Rui Wang, Miao Liu et al.

This paper introduces OpenLS-DGF, an adaptive logic synthesis dataset generation framework, to enhance machine learning~(ML) applications within the logic synthesis process. Previous dataset generation flows were tailored for specific tasks or lacked integrated machine learning capabilities. While OpenLS-DGF supports various machine learning tasks by encapsulating the three fundamental steps of logic synthesis: Boolean representation, logic optimization, and technology mapping. It preserves the original information in both Verilog and machine-learning-friendly GraphML formats. The verilog files offer semi-customizable capabilities, enabling researchers to insert additional steps and incrementally refine the generated dataset. Furthermore, OpenLS-DGF includes an adaptive circuit engine that facilitates the final dataset management and downstream tasks. The generated OpenLS-D-v1 dataset comprises 46 combinational designs from established benchmarks, totaling over 966,000 Boolean circuits. OpenLS-D-v1 supports integrating new data features, making it more versatile for new challenges. This paper demonstrates the versatility of OpenLS-D-v1 through four distinct downstream tasks: circuit classification, circuit ranking, quality of results (QoR) prediction, and probability prediction. Each task is chosen to represent essential steps of logic synthesis, and the experimental results show the generated dataset from OpenLS-DGF achieves prominent diversity and applicability. The source code and datasets are available at https://github.com/Logic-Factory/ACE/blob/master/OpenLS-DGF/readme.md.

Junfeng Liu, Christopher Symons, Ranga Raju Vatsavai

Recent advances in machine learning and deep learning have led to the widespread use of Conversational AI in many practical applications. However, it is still very challenging to leverage auxiliary information that can provide conversational context or personalized tuning to improve the quality of conversations. For example, there has only been limited research on using an individuals persona information to improve conversation quality, and even state-of-the-art conversational AI techniques are unable to effectively leverage signals from heterogeneous sources of auxiliary data, such as multi-modal interaction data, demographics, SDOH data, etc. In this paper, we present a novel Persona-Coded Poly-Encoder method that leverages persona information in a multi-stream encoding scheme to improve the quality of response generation for conversations. To show the efficacy of the proposed method, we evaluate our method on two different persona-based conversational datasets, and compared against two state-of-the-art methods. Our experimental results and analysis demonstrate that our method can improve conversation quality over the baseline method Poly-Encoder by 3.32% and 2.94% in terms of BLEU score and HR@1, respectively. More significantly, our method offers a path to better utilization of multi-modal data in conversational tasks. Lastly, our study outlines several challenges and future research directions for advancing personalized conversational AI technology.

Liwei Ni, Jiaxi Zhang, Shenggen Zheng et al.

Boolean equivalence allows Boolean networks with identical functionality to exhibit diverse graph structures. This gives more room for exploration in logic optimization, while also posing a challenge for tasks involving consistency between Boolean networks. To tackle this challenge, we introduce BoolSkeleton, a novel Boolean network skeletonization method that improves the consistency and reliability of design-specific evaluations. BoolSkeleton comprises two key steps: preprocessing and reduction. In preprocessing, the Boolean network is transformed into a defined Boolean dependency graph, where nodes are assigned the functionality-related status. Next, the homogeneous and heterogeneous patterns are defined for the node-level pattern reduction step. Heterogeneous patterns are preserved to maintain critical functionality-related dependencies, while homogeneous patterns can be reduced. Parameter K of the pattern further constrains the fanin size of these patterns, enabling fine-tuned control over the granularity of graph reduction. To validate BoolSkeleton's effectiveness, we conducted four analysis/downstream tasks around the Boolean network: compression analysis, classification, critical path analysis, and timing prediction, demonstrating its robustness across diverse scenarios. Furthermore, it improves above 55% in the average accuracy compared to the original Boolean network for the timing prediction task. These experiments underscore the potential of BoolSkeleton to enhance design consistency in logic synthesis.

StepFun, Bin Wang, Bojun Wang et al.

Large language models (LLMs) face low hardware efficiency during decoding, especially for long-context reasoning tasks. This paper introduces Step-3, a 321B-parameter VLM with hardware-aware model-system co-design optimized for minimizing decoding costs. Step-3 innovates in two key dimensions: (1) A novel Multi-Matrix Factorization Attention (MFA) mechanism that significantly reduces both KV cache size and computation while maintaining high attention expressiveness, and (2) Attention-FFN Disaggregation (AFD), a distributed inference system that decouples attention and Feed-Forward Network (FFN) layers into specialized subsystems. This co-design achieves unprecedented cost efficiency: Step-3 significantly reduces theoretical decoding costs compared with models like DeepSeek-V3 and Qwen3 MoE 235B, with the gains widening at longer context. Step-3 achieves low cost while activating 38B parameters per token (more than DeepSeek-V3 and Qwen3 MoE 235B), demonstrating that hardware-aligned attention arithmetic intensity, MoE sparsity, and AFD are critical to cost-effectiveness. We perform a head-to-head comparison with DeepSeek-V3 in its favorable scenarios. Our implementation on Hopper GPUs achieves a decoding throughput of up to 4,039 tokens per second per GPU under 50ms TPOT SLA (4K context, FP8, no MTP). It is higher than DeepSeek-V3's 2,324 in the same setup and sets a new Pareto frontier for LLM decoding.

Jianqiang Xiao, Weiwen Guo, Junfeng Liu et al.

In the field of computer vision, data augmentation is widely used to enrich the feature complexity of training datasets with deep learning techniques. However, regarding the generalization capabilities of models, the difference in artificial features generated by data augmentation and natural visual features has not been fully revealed. This study introduces the concept of "visual representation variables" to define the possible visual variations in a task as a joint distribution of these variables. We focus on the visual representation variable "illumination", by simulating its distribution degradation and examining how data augmentation techniques enhance model performance on a classification task. Our goal is to investigate the differences in generalization between models trained with augmented data and those trained under real-world illumination conditions. Results indicate that after applying various data augmentation methods, model performance has significantly improved. Yet, a noticeable generalization gap still exists after utilizing various data augmentation methods, emphasizing the critical role of feature diversity in the training set for enhancing model generalization.

Liwei Ni, Zonglin Yang, Jiaxi Zhang et al.

Rewriting is a common procedure in logic synthesis aimed at improving the performance, power, and area (PPA) of circuits. The traditional reconvergence-driven And-Inverter Graph (AIG) rewriting method focuses solely on optimizing the reconvergence cone through Boolean algebra minimization. However, there exist opportunities to incorporate other node-rewriting algorithms that are better suited for specific cones. In this paper, we propose an adaptive reconvergence-driven AIG rewriting algorithm that combines two key techniques: multi-strategy-based AIG rewriting and strategy learning-based algorithm selection. The multi-strategy-based rewriting method expands upon the traditional approach by incorporating support for multi-node-rewriting algorithms, thus expanding the optimization space. Additionally, the strategy learning-based algorithm selection method determines the most suitable node-rewriting algorithm for a given cone. Experimental results demonstrate that our proposed method yields a significant average improvement of 5.567\% in size and 5.327\% in depth.

Qinghua Zhao, Jiaang Li, Lei Li et al.

Existing works have studied the impacts of the order of words within natural text. They usually analyze it by destroying the original order of words to create a scrambled sequence, and then comparing the models' performance between the original and scrambled sequences. The experimental results demonstrate marginal drops. Considering this findings, different hypothesis about word order is proposed, including ``the order of words is redundant with lexical semantics'', and ``models do not rely on word order''. In this paper, we revisit the aforementioned hypotheses by adding a order reconstruction perspective, and selecting datasets of different spectrum. Specifically, we first select four different datasets, and then design order reconstruction and continuing generation tasks. Empirical findings support that ChatGPT relies on word order to infer, but cannot support or negate the redundancy relations between word order lexical semantics.

Jingyuan Ma, Rui Li, Zheng Li et al. · pku

Emerging Large Reasoning Models (LRMs) consistently excel in mathematical and reasoning tasks, showcasing remarkable capabilities. However, the enhancement of reasoning abilities and the exposure of internal reasoning processes introduce new safety vulnerabilities. A critical question arises: when reasoning becomes intertwined with harmfulness, will LRMs become more vulnerable to jailbreaks in reasoning mode? To investigate this, we introduce HauntAttack, a novel and general-purpose black-box adversarial attack framework that systematically embeds harmful instructions into reasoning questions. Specifically, we modify key reasoning conditions in existing questions with harmful instructions, thereby constructing a reasoning pathway that guides the model step by step toward unsafe outputs. We evaluate HauntAttack on 11 LRMs and observe an average attack success rate of 70\%, achieving up to 12 percentage points of absolute improvement over the strongest prior baseline. Our further analysis reveals that even advanced safety-aligned models remain highly susceptible to reasoning-based attacks, offering insights into the urgent challenge of balancing reasoning capability and safety in future model development.

Jianling Gao, Chongyang Tao, Xuelian Lin et al.

Semi-supervised anomaly detection (AD) has shown great promise by effectively leveraging limited labeled data. However, existing methods are typically structured around scoring individual points or simple pairs. Such {point- or pair-centric} view not only overlooks the contextual nature of anomalies, which are defined by their deviation from a collective group, but also fails to exploit the rich supervisory signals that can be generated from the combinatorial composition of sets. Consequently, such models struggle to exploit the high-order interactions within the data, which are critical for learning discriminative representations. To address these limitations, we propose SetAD, a novel framework that reframes semi-supervised AD as a Set-level Anomaly Detection task. SetAD employs an attention-based set encoder trained via a graded learning objective, where the model learns to quantify the degree of anomalousness within an entire set. This approach directly models the complex group-level interactions that define anomalies. Furthermore, to enhance robustness and score calibration, we propose a context-calibrated anomaly scoring mechanism, which assesses a point's anomaly score by aggregating its normalized deviations from peer behavior across multiple, diverse contextual sets. Extensive experiments on 10 real-world datasets demonstrate that SetAD significantly outperforms state-of-the-art models. Notably, we show that our model's performance consistently improves with increasing set size, providing strong empirical support for the set-based formulation of anomaly detection.

Rui Li, Jia-Chen Gu, Po-Nien Kung et al.

The rapid advancement of large language models (LLMs) has inspired researchers to integrate them extensively into the academic workflow, potentially reshaping how research is practiced and reviewed. While previous studies highlight the potential of LLMs in supporting research and peer review, their dual roles in the academic workflow and the complex interplay between research and review bring new risks that remain largely underexplored. In this study, we focus on how the deep integration of LLMs into both peer-review and research processes may influence scholarly fairness, examining the potential risks of using LLMs as reviewers by simulation. This simulation incorporates a research agent, which generates papers and revises, alongside a review agent, which assesses the submissions. Based on the simulation results, we conduct human annotations and identify pronounced misalignment between LLM-based reviews and human judgments: (1) LLM reviewers systematically inflate scores for LLM-authored papers, assigning them markedly higher scores than human-authored ones; (2) LLM reviewers persistently underrate human-authored papers with critical statements (e.g., risk, fairness), even after multiple revisions. Our analysis reveals that these stem from two primary biases in LLM reviewers: a linguistic feature bias favoring LLM-generated writing styles, and an aversion toward critical statements. These results highlight the risks and equity concerns posed to human authors and academic research if LLMs are deployed in the peer review cycle without adequate caution. On the other hand, revisions guided by LLM reviews yield quality gains in both LLM-based and human evaluations, illustrating the potential of the LLMs-as-reviewers for early-stage researchers and enhancing low-quality papers.

Tao Li, Jinlong Hu, Yang Wang et al.

LLM-brained web agents offer powerful capabilities for web automation but face a critical cost-performance trade-off. The challenge is amplified by web agents' inherently complex prompts that include goals, action histories, and environmental states, leading to degraded LLM ensemble performance. To address this, we introduce WebRouter, a novel query-specific router trained from an information-theoretic perspective. Our core contribution is a cost-aware Variational Information Bottleneck (ca-VIB) objective, which learns a compressed representation of the input prompt while explicitly penalizing the expected operational cost. Experiments on five real-world websites from the WebVoyager benchmark show that WebRouter reduces operational costs by a striking 87.8\% compared to a GPT-4o baseline, while incurring only a 3.8\% accuracy drop.

Junfeng Liu, Christopher T. Symons, Ranga Raju Vatsavai

Recent advancements in AI-driven conversational agents have exhibited immense potential of AI applications. Effective response generation is crucial to the success of these agents. While extensive research has focused on leveraging multiple auxiliary data sources (e.g., knowledge bases and personas) to enhance response generation, existing methods often struggle to efficiently extract relevant information from these sources. There are still clear limitations in the ability to combine versatile conversational capabilities with adherence to known facts and adaptation to large variations in user preferences and belief systems, which continues to hinder the wide adoption of conversational AI tools. This paper introduces a novel method, Conversational Agent for Multi-Source Auxiliary Context with Sparse and Symmetric Latent Interactions (CoMAC), for conversation generation, which employs specialized encoding streams and post-fusion grounding networks for multiple data sources to identify relevant persona and knowledge information for the conversation. CoMAC also leverages a novel text similarity metric that allows bi-directional information sharing among multiple sources and focuses on a selective subset of meaningful words. Our experiments show that CoMAC improves the relevant persona and knowledge prediction accuracies and response generation quality significantly over two state-of-the-art methods.

PeiFeng Wang, Jonathan Zamora, Junfeng Liu et al.

Humans use natural language to compose common concepts from their environment into plausible, day-to-day scene descriptions. However, such generative commonsense reasoning (GCSR) skills are lacking in state-of-the-art text generation methods. Descriptive sentences about arbitrary concepts generated by neural text generation models (e.g., pre-trained text-to-text Transformers) are often grammatically fluent but may not correspond to human common sense, largely due to their lack of mechanisms to capture concept relations, to identify implicit concepts, and to perform generalizable reasoning about unseen concept compositions. In this paper, we propose an Imagine-and-Verbalize (I&V) method, which learns to imagine a relational scene knowledge graph (SKG) with relations between the input concepts, and leverage the SKG as a constraint when generating a plausible scene description. We collect and harmonize a set of knowledge resources from different domains and modalities, providing a rich auxiliary supervision signal for I&V. The experiments demonstrate the effectiveness of I&V in improving language models on both concept-to-sentence and concept-to-story generation tasks, while enabling the model to learn well from fewer task examples and generate SKGs that make common sense to human annotators.

Yun Zhao, Yuqing Wang, Junfeng Liu et al.

COVID-19 has been a public health emergency of international concern since early 2020. Reliable forecasting is critical to diminish the impact of this disease. To date, a large number of different forecasting models have been proposed, mainly including statistical models, compartmental models, and deep learning models. However, due to various uncertain factors across different regions such as economics and government policy, no forecasting model appears to be the best for all scenarios. In this paper, we perform quantitative analysis of COVID-19 forecasting of confirmed cases and deaths across different regions in the United States with different forecasting horizons, and evaluate the relative impacts of the following three dimensions on the predictive performance (improvement and variation) through different evaluation metrics: model selection, hyperparameter tuning, and the length of time series required for training. We find that if a dimension brings about higher performance gains, if not well-tuned, it may also lead to harsher performance penalties. Furthermore, model selection is the dominant factor in determining the predictive performance. It is responsible for both the largest improvement and the largest variation in performance in all prediction tasks across different regions. While practitioners may perform more complicated time series analysis in practice, they should be able to achieve reasonable results if they have adequate insight into key decisions like model selection.

Xing Zhao, Manos Papagelis, Aijun An et al.

The bulk synchronous parallel (BSP) is a celebrated synchronization model for general-purpose parallel computing that has successfully been employed for distributed training of machine learning models. A prevalent shortcoming of the BSP is that it requires workers to wait for the straggler at every iteration. To ameliorate this shortcoming of classic BSP, we propose ELASTICBSP a model that aims to relax its strict synchronization requirement. The proposed model offers more flexibility and adaptability during the training phase, without sacrificing on the accuracy of the trained model. We also propose an efficient method that materializes the model, named ZIPLINE. The algorithm is tunable and can effectively balance the trade-off between quality of convergence and iteration throughput, in order to accommodate different environments or applications. A thorough experimental evaluation demonstrates that our proposed ELASTICBSP model converges faster and to a higher accuracy than the classic BSP. It also achieves comparable (if not higher) accuracy than the other sensible synchronization models.

Shima Khoshraftar, Sedigheh Mahdavi, Aijun An et al.

Many real world networks are very large and constantly change over time. These dynamic networks exist in various domains such as social networks, traffic networks and biological interactions. To handle large dynamic networks in downstream applications such as link prediction and anomaly detection, it is essential for such networks to be transferred into a low dimensional space. Recently, network embedding, a technique that converts a large graph into a low-dimensional representation, has become increasingly popular due to its strength in preserving the structure of a network. Efficient dynamic network embedding, however, has not yet been fully explored. In this paper, we present a dynamic network embedding method that integrates the history of nodes over time into the current state of nodes. The key contribution of our work is 1) generating dynamic network embedding by combining both dynamic and static node information 2) tracking history of neighbors of nodes using LSTM 3) significantly decreasing the time and memory by training an autoencoder LSTM model using temporal walks rather than adjacency matrices of graphs which are the common practice. We evaluate our method in multiple applications such as anomaly detection, link prediction and node classification in datasets from various domains.

Xing Zhao, Aijun An, Junfeng Liu et al.

Deep learning is a popular machine learning technique and has been applied to many real-world problems. However, training a deep neural network is very time-consuming, especially on big data. It has become difficult for a single machine to train a large model over large datasets. A popular solution is to distribute and parallelize the training process across multiple machines using the parameter server framework. In this paper, we present a distributed paradigm on the parameter server framework called Dynamic Stale Synchronous Parallel (DSSP) which improves the state-of-the-art Stale Synchronous Parallel (SSP) paradigm by dynamically determining the staleness threshold at the run time. Conventionally to run distributed training in SSP, the user needs to specify a particular staleness threshold as a hyper-parameter. However, a user does not usually know how to set the threshold and thus often finds a threshold value through trial and error, which is time-consuming. Based on workers' recent processing time, our approach DSSP adaptively adjusts the threshold per iteration at running time to reduce the waiting time of faster workers for synchronization of the globally shared parameters, and consequently increases the frequency of parameters updates (increases iteration throughput), which speedups the convergence rate. We compare DSSP with other paradigms such as Bulk Synchronous Parallel (BSP), Asynchronous Parallel (ASP), and SSP by running deep neural networks (DNN) models over GPU clusters in both homogeneous and heterogeneous environments. The results show that in a heterogeneous environment where the cluster consists of mixed models of GPUs, DSSP converges to a higher accuracy much earlier than SSP and BSP and performs similarly to ASP. In a homogeneous distributed cluster, DSSP has more stable and slightly better performance than SSP and ASP, and converges much faster than BSP.

Jun Long, Qunfeng Liu, Xinpan Yuan et al.

Image similarity measures play an important role in nearest neighbor search and duplicate detection for large-scale image datasets. Recently, Minwise Hashing (or Minhash) and its related hashing algorithms have achieved great performances in large-scale image retrieval systems. However, there are a large number of comparisons for image pairs in these applications, which may spend a lot of computation time and affect the performance. In order to quickly obtain the pairwise images that theirs similarities are higher than the specific threshold T (e.g., 0.5), we propose a dynamic threshold filter of Minwise Hashing for image similarity measures. It greatly reduces the calculation time by terminating the unnecessary comparisons in advance. We also find that the filter can be extended to other hashing algorithms, on when the estimator satisfies the binomial distribution, such as b-Bit Minwise Hashing, One Permutation Hashing, etc. In this pager, we use the Bag-of-Visual-Words (BoVW) model based on the Scale Invariant Feature Transform (SIFT) to represent the image features. We have proved that the filter is correct and effective through the experiment on real image datasets.

Yicheng He, Junfeng Liu, Xia Ning

Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection problem as to accurately predicting 1). the ranking positions of sensitive drugs and 2). the ranking orders among sensitive drugs in cancer cell lines based on their responses to cancer drugs. We have developed a new learning-to-rank method, denoted as pLETORg , that predicts drug ranking structures in each cell line via using drug latent vectors and cell line latent vectors. The pLETORg method learns such latent vectors through explicitly enforcing that, in the drug ranking list of each cell line, the sensitive drugs are pushed above insensitive drugs, and meanwhile the ranking orders among sensitive drugs are correct. Genomics information on cell lines is leveraged in learning the latent vectors. Our experimental results on a benchmark cell line-drug response dataset demonstrate that the new pLETORg significantly outperforms the state-of-the-art method in prioritizing new sensitive drugs.