Fasil Gadjimuradov

Lukas Folle, Katharian Tkotz, Fasil Gadjimuradov et al.

The onset of rheumatic diseases such as rheumatoid arthritis is typically subclinical, which results in challenging early detection of the disease. However, characteristic changes in the anatomy can be detected using imaging techniques such as MRI or CT. Modern imaging techniques such as chemical exchange saturation transfer (CEST) MRI drive the hope to improve early detection even further through the imaging of metabolites in the body. To image small structures in the joints of patients, typically one of the first regions where changes due to the disease occur, a high resolution for the CEST MR imaging is necessary. Currently, however, CEST MR suffers from an inherently low resolution due to the underlying physical constraints of the acquisition. In this work we compared established up-sampling techniques to neural network-based super-resolution approaches. We could show, that neural networks are able to learn the mapping from low-resolution to high-resolution unsaturated CEST images considerably better than present methods. On the test set a PSNR of 32.29dB (+10%), a NRMSE of 0.14 (+28%), and a SSIM of 0.85 (+15%) could be achieved using a ResNet neural network, improving the baseline considerably. This work paves the way for the prospective investigation of neural networks for super-resolution CEST MRI and, followingly, might lead to a earlier detection of the onset of rheumatic diseases.

Fasil Gadjimuradov, Thomas Benkert, Marcel Dominik Nickel et al.

Purpose: To develop an algorithm for robust partial Fourier (PF) reconstruction applicable to diffusion-weighted (DW) images with non-smooth phase variations. Methods: Based on an unrolled proximal splitting algorithm, a neural network architecture is derived which alternates between data consistency operations and regularization implemented by recurrent convolutions. In order to exploit correlations, multiple repetitions of the same slice are jointly reconstructed under consideration of permutation-equivariance. The algorithm is trained on DW liver data of 60 volunteers and evaluated on retrospectively and prospectively sub-sampled data of different anatomies and resolutions. Results: The proposed method is able to significantly outperform conventional PF techniques on retrospectively sub-sampled data in terms of quantitative measures as well as perceptual image quality. In this context, joint reconstruction of repetitions as well as the particular type of recurrent network unrolling are found to be beneficial with respect to reconstruction quality. On prospectively PF-sampled data, the proposed method enables DW imaging with higher signal without sacrificing image resolution or introducing additional artifacts. Alternatively, it can be used to counter the TE increase in acquisitions with higher resolution. Further, generalizability can be shown to prospective brain data exhibiting anatomies and contrasts not present in the training set. Conclusion: This work demonstrates that robust PF reconstruction of DW data is feasible even at strong PF factors in anatomies prone to phase variations. Since the proposed method does not rely on smoothness priors of the phase but uses learned recurrent convolutions instead, artifacts of conventional PF methods can be avoided.