Mingyuan Zhou

Zhangsihao Yang, Mingyuan Zhou, Mengyi Shan et al.

Our paper aims to generate diverse and realistic animal motion sequences from textual descriptions, without a large-scale animal text-motion dataset. While the task of text-driven human motion synthesis is already extensively studied and benchmarked, it remains challenging to transfer this success to other skeleton structures with limited data. In this work, we design a model architecture that imitates Generative Pretraining Transformer (GPT), utilizing prior knowledge learned from human data to the animal domain. We jointly train motion autoencoders for both animal and human motions and at the same time optimize through the similarity scores among human motion encoding, animal motion encoding, and text CLIP embedding. Presenting the first solution to this problem, we are able to generate animal motions with high diversity and fidelity, quantitatively and qualitatively outperforming the results of training human motion generation baselines on animal data. Additionally, we introduce AnimalML3D, the first text-animal motion dataset with 1240 animation sequences spanning 36 different animal identities. We hope this dataset would mediate the data scarcity problem in text-driven animal motion generation, providing a new playground for the research community.

Liyang Xie, Haoran Zhang, Zhendong Wang et al.

Diffusion- and flow-based generative models have recently demonstrated strong performance in protein backbone generation tasks, offering unprecedented capabilities for de novo protein design. However, while achieving notable performance in generation quality, these models are limited by their generating speed, often requiring hundreds of iterative steps in the reverse-diffusion process. This computational bottleneck limits their practical utility in large-scale protein discovery, where thousands to millions of candidate structures are needed. To address this challenge, we explore the techniques of score distillation, which has shown great success in reducing the number of sampling steps in the vision domain while maintaining high generation quality. However, a straightforward adaptation of these methods results in unacceptably low designability. Through extensive study, we have identified how to appropriately adapt Score identity Distillation (SiD), a state-of-the-art score distillation strategy, to train few-step protein backbone generators which significantly reduce sampling time, while maintaining comparable performance to their pretrained teacher model. In particular, multistep generation combined with inference time noise modulation is key to the success. We demonstrate that our distilled few-step generators achieve more than a 20-fold improvement in sampling speed, while achieving similar levels of designability, diversity, and novelty as the Proteina teacher model. This reduction in inference cost enables large-scale in silico protein design, thereby bringing diffusion-based models closer to real-world protein engineering applications. The PyTorch implementation is available at https://github.com/LY-Xie/SiD_Protein

Haoran Zhang, Mingyuan Zhou, Wesley Tansey

Spatial profiling technologies in biology, such as imaging mass cytometry (IMC) and spatial transcriptomics (ST), generate high-dimensional, multi-channel data with strong spatial alignment and complex inter-channel relationships. Generative modeling of such data requires jointly capturing intra- and inter-channel structure, while also generalizing across arbitrary combinations of observed and missing channels for practical application. Existing diffusion-based models generally assume low-dimensional inputs (e.g., RGB images) and rely on simple conditioning mechanisms that break spatial correspondence and ignore inter-channel dependencies. This work proposes a unified diffusion framework for controllable generation over structured and spatial biological data. Our model contains two key innovations: (1) a hierarchical feature injection mechanism that enables multi-resolution conditioning on spatially aligned channels, and (2) a combination of latent-space and output-space channel-wise attention to capture inter-channel relationships. To support flexible conditioning and generalization to arbitrary subsets of observed channels, we train the model using a random masking strategy, enabling it to reconstruct missing channels from any combination of inputs. We demonstrate state-of-the-art performance across both spatial and non-spatial prediction tasks, including protein imputation in IMC and gene-to-protein prediction in single-cell datasets, and show strong generalization to unseen conditional configurations.

Mingyuan Zhou, Yu Ji, Yuqi Ding et al.

Recovering the shape and reflectance of non-Lambertian surfaces remains a challenging problem in computer vision since the view-dependent appearance invalidates traditional photo-consistency constraint. In this paper, we introduce a novel concentric multi-spectral light field (CMSLF) design that is able to recover the shape and reflectance of surfaces with arbitrary material in one shot. Our CMSLF system consists of an array of cameras arranged on concentric circles where each ring captures a specific spectrum. Coupled with a multi-spectral ring light, we are able to sample viewpoint and lighting variations in a single shot via spectral multiplexing. We further show that such concentric camera/light setting results in a unique pattern of specular changes across views that enables robust depth estimation. We formulate a physical-based reflectance model on CMSLF to estimate depth and multi-spectral reflectance map without imposing any surface prior. Extensive synthetic and real experiments show that our method outperforms state-of-the-art light field-based techniques, especially in non-Lambertian scenes.

Zhang Chen, Yu Ji, Mingyuan Zhou et al.

We present a new color photometric stereo (CPS) method that recovers high quality, detailed 3D face geometry in a single shot. Our system uses three uncalibrated near point lights of different colors and a single camera. For robust self-calibration of the light sources, we use 3D morphable model (3DMM) and semantic segmentation of facial parts. We address the spectral ambiguity problem by incorporating albedo consensus, albedo similarity, and proxy prior into a unified framework. We avoid the need for spatial constancy of albedo; instead, we use a new measure for albedo similarity that is based on the albedo norm profile. Experiments show that our new approach produces state-of-the-art results from single image with high-fidelity geometry that includes details such as wrinkles.