Yiwen Lu

Yiwen Lu, Lu Li, Dazheng Zhang et al.

Sample size calculations for power analysis are critical for clinical research and trial design, yet their complexity and reliance on statistical expertise create barriers for many researchers. We introduce PowerGPT, an AI-powered system integrating large language models (LLMs) with statistical engines to automate test selection and sample size estimation in trial design. In a randomized trial to evaluate its effectiveness, PowerGPT significantly improved task completion rates (99.3% vs. 88.9% for test selection, 99.3% vs. 77.8% for sample size calculation) and accuracy (94.1% vs. 55.4% in sample size estimation, p < 0.001), while reducing average completion time (4.0 vs. 9.3 minutes, p < 0.001). These gains were consistent across various statistical tests and benefited both statisticians and non-statisticians as well as bridging expertise gaps. Already under deployment across multiple institutions, PowerGPT represents a scalable AI-driven approach that enhances accessibility, efficiency, and accuracy in statistical power analysis for clinical research.

Ran Xu, Yiwen Lu, Chang Liu et al.

Electronic Health Records (EHRs) contain rich patient information and are crucial for clinical research and practice. In recent years, deep learning models have been applied to EHRs, but they often rely on massive features, which may not be readily available for all patients. We propose HTP-Star, which leverages hypergraph structures with a pretrain-then-finetune framework for modeling EHR data, enabling seamless integration of additional features. Additionally, we design two techniques, namely (1) Smoothness-inducing Regularization and (2) Group-balanced Reweighting, to enhance the model's robustness during fine-tuning. Through experiments conducted on two real EHR datasets, we demonstrate that HTP-Star consistently outperforms various baselines while striking a balance between patients with basic and extra features.

Xiaoteng Ma, Yiqin Yang, Chenghao Li et al.

Value-based methods of multi-agent reinforcement learning (MARL), especially the value decomposition methods, have been demonstrated on a range of challenging cooperative tasks. However, current methods pay little attention to the interaction between agents, which is essential to teamwork in games or real life. This limits the efficiency of value-based MARL algorithms in the two aspects: collaborative exploration and value function estimation. In this paper, we propose a novel cooperative MARL algorithm named as interactive actor-critic~(IAC), which models the interaction of agents from the perspectives of policy and value function. On the policy side, a multi-agent joint stochastic policy is introduced by adopting a collaborative exploration module, which is trained by maximizing the entropy-regularized expected return. On the value side, we use the shared attention mechanism to estimate the value function of each agent, which takes the impact of the teammates into consideration. At the implementation level, we extend the value decomposition methods to continuous control tasks and evaluate IAC on benchmark tasks including classic control and multi-agent particle environments. Experimental results indicate that our method outperforms the state-of-the-art approaches and achieves better performance in terms of cooperation.