Salil Patel

Blaise Delaney, Salil Patel, Yuji Xing et al.

We introduce Sonata, a compact latent world model for six-axis trunk IMU representation learning under clinical data scarcity. Clinical cohorts typically comprise tens to hundreds of patients, making web-scale masked-reconstruction objectives poorly matched to the problem. Sonata is a 3.77 M-parameter hybrid model, pre-trained on a harmonised corpus of nine public datasets (739 subjects, 190k windows) with a latent world-model objective that predicts future state rather than reconstructing raw sensor traces. In a controlled comparison against a matched autoregressive forecasting baseline (MAE) on the same backbone, Sonata yields consistently stronger frozen-probe clinical discrimination, prospective fall-risk prediction, and cross-cohort transfer across a 14-arm evaluation suite, while producing higher-rank, more structured latent representations. At 3.77 M parameters the model is compatible with on-device wearable inference, offering a step toward general kinematic world models for neurological assessment.

Salil Patel

Medical data range from genomic sequences and retinal photographs to structured laboratory results and unstructured clinical narratives. Although these modalities appear disparate, many encode convergent information about a single underlying physiological state. The Latent Space Hypothesis frames each observation as a projection of a unified, hierarchically organized manifold -- much like shadows cast by the same three-dimensional object. Within this learned geometric representation, an individual's health status occupies a point, disease progression traces a trajectory, and therapeutic intervention corresponds to a directed vector. Interpreting heterogeneous evidence in a shared space provides a principled way to re-examine eponymous conditions -- such as Parkinson's or Crohn's -- that often mask multiple pathophysiological entities and involve broader anatomical domains than once believed. By revealing sub-trajectories and patient-specific directions of change, the framework supplies a quantitative rationale for personalised diagnosis, longitudinal monitoring, and tailored treatment, moving clinical practice away from grouping by potentially misleading labels toward navigation of each person's unique trajectory. Challenges remain -- bias amplification, data scarcity for rare disorders, privacy, and the correlation-causation divide -- but scale-aware encoders, continual learning on longitudinal data streams, and perturbation-based validation offer plausible paths forward.