Tianhao Li

Tianhao Li, Sandesh Shetty, Advaith Kamath et al.

Large pre-trained language models (LLMs) have been shown to have significant potential in few-shot learning across various fields, even with minimal training data. However, their ability to generalize to unseen tasks in more complex fields, such as biology, has yet to be fully evaluated. LLMs can offer a promising alternative approach for biological inference, particularly in cases where structured data and sample size are limited, by extracting prior knowledge from text corpora. Our proposed few-shot learning approach uses LLMs to predict the synergy of drug pairs in rare tissues that lack structured data and features. Our experiments, which involved seven rare tissues from different cancer types, demonstrated that the LLM-based prediction model achieved significant accuracy with very few or zero samples. Our proposed model, the CancerGPT (with $\sim$ 124M parameters), was even comparable to the larger fine-tuned GPT-3 model (with $\sim$ 175B parameters). Our research is the first to tackle drug pair synergy prediction in rare tissues with limited data. We are also the first to utilize an LLM-based prediction model for biological reaction prediction tasks.

Kyle Cox, Jiawei Xu, Yikun Han et al.

An interesting behavior in large language models (LLMs) is prompt sensitivity. When provided with different but semantically equivalent versions of the same prompt, models may produce very different distributions of answers. This suggests that the uncertainty reflected in a model's output distribution for one prompt may not reflect the model's uncertainty about the meaning of the prompt. We model prompt sensitivity as a type of generalization error, and show that sampling across the semantic ``concept space'' with paraphrasing perturbations improves uncertainty calibration without compromising accuracy. Additionally, we introduce a new metric for uncertainty decomposition in black-box LLMs that improves upon entropy-based decomposition by modeling semantic continuities in natural language generation. We show that this decomposition metric can be used to quantify how much LLM uncertainty is attributed to prompt sensitivity. Our work introduces a new way to improve uncertainty calibration in prompt-sensitive language models, and provides evidence that some LLMs fail to exhibit consistent general reasoning about the meanings of their inputs.

Tianhao Li, Yang Li, Mengtian Li et al.

Accurately perceiving dynamic environments is a fundamental task for autonomous driving and robotic systems. Existing methods inadequately utilize temporal information, relying mainly on local temporal interactions between adjacent frames and failing to leverage global sequence information effectively. To address this limitation, we investigate how to effectively aggregate global temporal features from temporal sequences, aiming to achieve occupancy representations that efficiently utilize global temporal information from historical observations. For this purpose, we propose a global temporal aggregation denoising network named GTAD, introducing a global temporal information aggregation framework as a new paradigm for holistic 3D scene understanding. Our method employs an in-model latent denoising network to aggregate local temporal features from the current moment and global temporal features from historical sequences. This approach enables the effective perception of both fine-grained temporal information from adjacent frames and global temporal patterns from historical observations. As a result, it provides a more coherent and comprehensive understanding of the environment. Extensive experiments on the nuScenes and Occ3D-nuScenes benchmark and ablation studies demonstrate the superiority of our method.