Qiushi Yang

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently, multimodal deep learning, which integrates histopathology slides and molecular biomarkers, has achieved a promising performance in glioma grading. Despite great progress, due to the intra-modality complexity and inter-modality heterogeneity, existing studies suffer from inadequate histopathology representation learning and inefficient molecular-pathology knowledge alignment. These two issues hinder existing methods to precisely interpret diagnostic molecular-pathology features, thereby limiting their grading performance. Moreover, the real-world applicability of existing multimodal approaches is significantly restricted as molecular biomarkers are not always available during clinical deployment. To address these problems, we introduce a novel Focus on Focus (FoF) framework with paired pathology-genomic training and applicable pathology-only inference, enhancing molecular-pathology representation effectively. Specifically, we propose a Focus-oriented Representation Learning (FRL) module to encourage the model to identify regions positively or negatively related to glioma grading and guide it to focus on the diagnostic areas with a consistency constraint. To effectively link the molecular biomarkers to morphological features, we propose a Multi-view Cross-modal Alignment (MCA) module that projects histopathology representations into molecular subspaces, aligning morphological features with corresponding molecular biomarker status by supervised contrastive learning. Experiments on the TCGA GBM-LGG dataset demonstrate that our FoF framework significantly improves the glioma grading. Remarkably, our FoF achieves superior performance using only histopathology slides compared to existing multimodal methods. The source code is available at https://github.com/peterlipan/FoF.

Shengyuan Liu, Zhen Chen, Qiushi Yang et al.

Automated diagnostic systems (ADS) have shown significant potential in the early detection of polyps during endoscopic examinations, thereby reducing the incidence of colorectal cancer. However, due to high annotation costs and strict privacy concerns, acquiring high-quality endoscopic images poses a considerable challenge in the development of ADS. Despite recent advancements in generating synthetic images for dataset expansion, existing endoscopic image generation algorithms failed to accurately generate the details of polyp boundary regions and typically required medical priors to specify plausible locations and shapes of polyps, which limited the realism and diversity of the generated images. To address these limitations, we present Polyp-Gen, the first full-automatic diffusion-based endoscopic image generation framework. Specifically, we devise a spatial-aware diffusion training scheme with a lesion-guided loss to enhance the structural context of polyp boundary regions. Moreover, to capture medical priors for the localization of potential polyp areas, we introduce a hierarchical retrieval-based sampling strategy to match similar fine-grained spatial features. In this way, our Polyp-Gen can generate realistic and diverse endoscopic images for building reliable ADS. Extensive experiments demonstrate the state-of-the-art generation quality, and the synthetic images can improve the downstream polyp detection task. Additionally, our Polyp-Gen has shown remarkable zero-shot generalizability on other datasets. The source code is available at https://github.com/CUHK-AIM-Group/Polyp-Gen.

Li Pan, Yupei Zhang, Qiushi Yang et al.

Recently computer-aided diagnosis has demonstrated promising performance, effectively alleviating the workload of clinicians. However, the inherent sample imbalance among different diseases leads algorithms biased to the majority categories, leading to poor performance for rare categories. Existing works formulated this challenge as a long-tailed problem and attempted to tackle it by decoupling the feature representation and classification. Yet, due to the imbalanced distribution and limited samples from tail classes, these works are prone to biased representation learning and insufficient classifier calibration. To tackle these problems, we propose a new Long-tailed Medical Diagnosis (LMD) framework for balanced medical image classification on long-tailed datasets. In the initial stage, we develop a Relation-aware Representation Learning (RRL) scheme to boost the representation ability by encouraging the encoder to capture intrinsic semantic features through different data augmentations. In the subsequent stage, we propose an Iterative Classifier Calibration (ICC) scheme to calibrate the classifier iteratively. This is achieved by generating a large number of balanced virtual features and fine-tuning the encoder using an Expectation-Maximization manner. The proposed ICC compensates for minority categories to facilitate unbiased classifier optimization while maintaining the diagnostic knowledge in majority classes. Comprehensive experiments on three public long-tailed medical datasets demonstrate that our LMD framework significantly surpasses state-of-the-art approaches. The source code can be accessed at https://github.com/peterlipan/LMD.

Yupei Zhang, Li Pan, Qiushi Yang et al.

Medical multi-modal pre-training has revealed promise in computer-aided diagnosis by leveraging large-scale unlabeled datasets. However, existing methods based on masked autoencoders mainly rely on data-level reconstruction tasks, but lack high-level semantic information. Furthermore, two significant heterogeneity challenges hinder the transfer of pre-trained knowledge to downstream tasks, \textit{i.e.}, the distribution heterogeneity between pre-training data and downstream data, and the modality heterogeneity within downstream data. To address these challenges, we propose a Unified Medical Multi-modal Diagnostic (UMD) framework with tailored pre-training and downstream tuning strategies. Specifically, to enhance the representation abilities of vision and language encoders, we propose the Multi-level Reconstruction Pre-training (MR-Pretrain) strategy, including a feature-level and data-level reconstruction, which guides models to capture the semantic information from masked inputs of different modalities. Moreover, to tackle two kinds of heterogeneities during the downstream tuning, we present the heterogeneity-combat downstream tuning strategy, which consists of a Task-oriented Distribution Calibration (TD-Calib) and a Gradient-guided Modality Coordination (GM-Coord). In particular, TD-Calib fine-tunes the pre-trained model regarding the distribution of downstream datasets, and GM-Coord adjusts the gradient weights according to the dynamic optimization status of different modalities. Extensive experiments on five public medical datasets demonstrate the effectiveness of our UMD framework, which remarkably outperforms existing approaches on three kinds of downstream tasks.

Qiushi Yang, Yuan Yao, Miaomiao Cui et al.

The recent Segment Anything Model 2 (SAM2) has demonstrated exceptional capabilities in interactive object segmentation for both images and videos. However, as a foundational model on interactive segmentation, SAM2 performs segmentation directly based on mask memory from the past six frames, leading to two significant challenges. Firstly, during inference in videos, objects may disappear since SAM2 relies solely on memory without accounting for object motion information, which limits its long-range object tracking capabilities. Secondly, its memory is constructed from fixed past frames, making it susceptible to challenges associated with object disappearance or occlusion, due to potentially inaccurate segmentation results in memory. To address these problems, we present MoSAM, incorporating two key strategies to integrate object motion cues into the model and establish more reliable feature memory. Firstly, we propose Motion-Guided Prompting (MGP), which represents the object motion in both sparse and dense manners, then injects them into SAM2 through a set of motion-guided prompts. MGP enables the model to adjust its focus towards the direction of motion, thereby enhancing the object tracking capabilities. Furthermore, acknowledging that past segmentation results may be inaccurate, we devise a Spatial-Temporal Memory Selection (ST-MS) mechanism that dynamically identifies frames likely to contain accurate segmentation in both pixel- and frame-level. By eliminating potentially inaccurate mask predictions from memory, we can leverage more reliable memory features to exploit similar regions for improving segmentation results. Extensive experiments on various benchmarks of video object segmentation and video instance segmentation demonstrate that our MoSAM achieves state-of-the-art results compared to other competitors.

Qiushi Yang, Yingjie Chen, Yuan Yao et al.

Text-to-video (T2V) generation has achieved remarkable progress in producing high-quality videos aligned with textual prompts. However, aligning synthesized videos with nuanced human preference remains challenging due to the subjective and multifaceted nature of human judgment. Existing video preference alignment methods rely on costly human annotations or utilize proxy metrics to predict preference, which lacks the understanding of human preference logic. Moreover, they usually directly align T2V models with the overall preference distribution, ignoring potential conflict dimensions like motion dynamics and visual quality, which may bias models towards low-motion content. To address these issues, we present Motion-corrective alignment with Self-critic hierarchical Reasoning (McSc), a three-stage reinforcement learning framework for robust preference modeling and alignment. Firstly, Self-critic Dimensional Reasoning (ScDR) trains a generative reward model (RM) to decompose preferences into per-dimension assessments, using self-critic reasoning chains for reliable learning. Secondly, to achieve holistic video comparison, we introduce Hierarchical Comparative Reasoning (HCR) for structural multi-dimensional reasoning with hierarchical reward supervision. Finally, using RM-preferred videos, we propose Motion-corrective Direct Preference Optimization (McDPO) to optimize T2V models, while dynamically re-weighting alignment objective to mitigate bias towards low-motion content. Experiments show that McSc achieves superior performance in human preference alignment and generates videos with high-motion dynamic.