Kaini Wang

Jun Ma, Feifei Li, Sumin Kim et al.

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical practice. In this work, we organized the first international competition dedicated to promptable medical image segmentation, featuring a large-scale dataset spanning nine common imaging modalities from over 20 different institutions. The top teams developed lightweight segmentation foundation models and implemented an efficient inference pipeline that substantially reduced computational requirements while maintaining state-of-the-art segmentation accuracy. Moreover, the post-challenge phase advanced the algorithms through the design of performance booster and reproducibility tasks, resulting in improved algorithms and validated reproducibility of the winning solution. Furthermore, the best-performing algorithms have been incorporated into the open-source software with a user-friendly interface to facilitate clinical adoption. The data and code are publicly available to foster the further development of medical image segmentation foundation models and pave the way for impactful real-world applications.

Changjin Sun, Zhuo Hu, Kaini Wang et al.

Reconstructing anatomically faithful vascular structures from clinically accessible imaging modalities is of substantial clinical significance. However, existing cross-modal translation methods mainly emphasize pixel-level fidelity or visual realism and treat structure preservation as a property of the final output rather than an invariant of the generative process. This limitation often leads to structural discontinuities and artifacts, compromising anatomical coherence and clinical reliability. In this work, we propose a Structure-Preserving Mean Flow (SPMF) framework that formulates vascular image translation as a topology-invariant transport process. Based on a structural invariance principle, we derive an orthogonality constraint on the flow velocity field that formally separates appearance transport from topological distortion. We implement this constraint as a time-weighted surrogate objective within a Brownian bridge diffusion model to preserve topology at every diffusion step. Moreover, we propose a Prototype-Guided Structural Refinement (PGSR) module to align degraded inference-time structures with reliable training-time structures. Experiments on paired NIRII-to-2PF and fundus datasets demonstrate consistent improvements over state-of-the-art methods, achieving peak PSNR values of 24.96 dB and 24.83 dB, respectively.

Yi Tang, Kaini Wang, Yang Chen et al.

Developing general artificial intelligence (AI) systems to support endoscopic image diagnosis is an emerging research priority. Existing methods based on large-scale pretraining often lack unified coordination across tasks and struggle to handle the multi-step processes required in complex clinical workflows. While AI agents have shown promise in flexible instruction parsing and tool integration across domains, their potential in endoscopy remains underexplored. To address this gap, we propose EndoAgent, the first memory-guided agent for vision-to-decision endoscopic analysis that integrates iterative reasoning with adaptive tool selection and collaboration. Built on a dual-memory design, it enables sophisticated decision-making by ensuring logical coherence through short-term action tracking and progressively enhancing reasoning acuity through long-term experiential learning. To support diverse clinical tasks, EndoAgent integrates a suite of expert-designed tools within a unified reasoning loop. We further introduce EndoAgentBench, a benchmark of 5,709 visual question-answer pairs that assess visual understanding and language generation capabilities in realistic scenarios. Extensive experiments show that EndoAgent consistently outperforms both general and medical multimodal models, exhibiting its strong flexibility and reasoning capabilities.