Allison Clarke

Guodong Long, Tao Shen, Yue Tan et al.

Privacy protection is an ethical issue with broad concern in Artificial Intelligence (AI). Federated learning is a new machine learning paradigm to learn a shared model across users or organisations without direct access to the data. It has great potential to be the next-general AI model training framework that offers privacy protection and therefore has broad implications for the future of digital health and healthcare informatics. Implementing an open innovation framework in the healthcare industry, namely open health, is to enhance innovation and creative capability of health-related organisations by building a next-generation collaborative framework with partner organisations and the research community. In particular, this game-changing collaborative framework offers knowledge sharing from diverse data with a privacy-preserving. This chapter will discuss how federated learning can enable the development of an open health ecosystem with the support of AI. Existing challenges and solutions for federated learning will be discussed.

Xueping Peng, Guodong Long, Tao Shen et al.

Representation learning on electronic health records (EHRs) plays a vital role in downstream medical prediction tasks. Although natural language processing techniques, such as recurrent neural networks, and self-attention, have been adapted for learning medical representations from hierarchical, time-stamped EHR data, they often struggle when either general or task-specific data are limited. Recent efforts have attempted to mitigate this challenge by incorporating medical ontologies (i.e., knowledge graphs) into self-supervised tasks like diagnosis prediction. However, two main issues remain: (1) small and uniform ontologies that lack diversity for robust learning, and (2) insufficient attention to the critical contexts or dependencies underlying patient journeys, which could further enhance ontology-based learning. To address these gaps, we propose MIPO (Mutual Integration of Patient Journey and Medical Ontology), a robust end-to-end framework that employs a Transformer-based architecture for representation learning. MIPO emphasizes task-specific representation learning through a sequential diagnosis prediction task, while also incorporating an ontology-based disease-typing task. A graph-embedding module is introduced to integrate information from patient visit records, thus alleviating data insufficiency. This setup creates a mutually reinforcing loop, where both patient-journey embedding and ontology embedding benefit from each other. We validate MIPO on two real-world benchmark datasets, showing that it consistently outperforms baseline methods under both sufficient and limited data conditions. Furthermore, the resulting diagnosis embeddings offer improved interpretability, underscoring the promise of MIPO for real-world healthcare applications.