4.9CRMay 26Code
The Fault in Our Drafts: Vulnerabilities in RPKI Specification and SoftwareOliver Jacobsen, Tobias Kirsch, Haya Schulmann et al.
The Resource Public Key Infrastructure (RPKI) secures the Internet's routing system by defining a complex trust and validation framework for certificates, Route Origin Authorizations (ROAs), manifests, and Certificate Revocation Lists (CRLs). These mechanisms are specified across dozens of RFCs. This paper presents the first comprehensive analysis of the causal link between flaws in RPKI Requests for Comments (RFCs) and vulnerabilities in implementations and real-world deployments. We reveal how vague, conflicting, or underspecified requirements in 50 RPKI RFCs propagate into inconsistent implementation behavior and operational failures. We conduct the first large-scale, impact-driven evaluation of RPKI specifications. Our methodology combines differential fuzzing of major RPKI implementations with Internet-wide crawling and validation log analysis, enabling us to trace practical vulnerabilities back to flawed RFC requirements. We uncover 61 previously undocumented inconsistencies in validation behavior, trace 23 directly to RFC flaws, and identify two novel vulnerabilities that were assigned CVEs. Our findings reveal that these are not isolated coding errors but rather systemic issues inherent in how RPKI standards are written, interpreted, and implemented. To mitigate these threats, we propose concrete recommendations and introduce a novel alerting service that monitors and reports live inconsistencies in RPKI deployments. Our open-source datasets, code, and tools support reproducibility and further research.
IVJul 19, 2021
Automatic and explainable grading of meningiomas from histopathology imagesJonathan Ganz, Tobias Kirsch, Lucas Hoffmann et al.
Meningioma is one of the most prevalent brain tumors in adults. To determine its malignancy, it is graded by a pathologist into three grades according to WHO standards. This grade plays a decisive role in treatment, and yet may be subject to inter-rater discordance. In this work, we present and compare three approaches towards fully automatic meningioma grading from histology whole slide images. All approaches are following a two-stage paradigm, where we first identify a region of interest based on the detection of mitotic figures in the slide using a state-of-the-art object detection deep learning network. This region of highest mitotic rate is considered characteristic for biological tumor behavior. In the second stage, we calculate a score corresponding to tumor malignancy based on information contained in this region using three different settings. In a first approach, image patches are sampled from this region and regression is based on morphological features encoded by a ResNet-based network. We compare this to learning a logistic regression from the determined mitotic count, an approach which is easily traceable and explainable. Lastly, we combine both approaches in a single network. We trained the pipeline on 951 slides from 341 patients and evaluated them on a separate set of 141 slides from 43 patients. All approaches yield a high correlation to the WHO grade. The logistic regression and the combined approach had the best results in our experiments, yielding correct predictions in 32 and 33 of all cases, respectively, with the image-based approach only predicting 25 cases correctly. Spearman's correlation was 0.716, 0.792 and 0.790 respectively. It may seem counterintuitive at first that morphological features provided by image patches do not improve model performance. Yet, this mirrors the criteria of the grading scheme, where mitotic count is the only unequivocal parameter.